Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA

Epilepsy Research

Volumn 65, Issue 1-2, 2005, Pages 11-22

  Ganor, Yonatan ^a   Goldberg Stern, Hadassa ^b,d   Lerman Sagie, Tally ^c,d   Teichberg, Vivian I ^a   Levite, Mia ^a,d  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^c WOLFSON MEDICAL CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

Antibodies; Autoimmunity; Double stranded DNA (dsDNA); Epilepsy; GluR3; Glutamate receptor; NR2A

Indexed keywords

AMPA RECEPTOR; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; DNA; GLUTAMATE RECEPTOR 3; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PEPTIDE DERIVATIVE; PROTEIN SUBUNIT;

ADOLESCENT; ANAMNESIS; ARTICLE; AUTOIMMUNE DISEASE; BRAIN INJURY; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS REACTION; DISEASE CLASSIFICATION; DISEASE MARKER; DNA STRAND; EPILEPSY; FEBRILE CONVULSION; FEMALE; HEALTH STATUS; HUMAN; INTRACTABLE EPILEPSY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SERUM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ANTIGENS, NUCLEAR; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CHILD; DNA; EPILEPSY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MODELS, BIOLOGICAL; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STATISTICS, NONPARAMETRIC;

EID: 22844433210     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2005.03.011     Document Type: Article

References (29)

1. C. Antozzi, T. Granata, N. Aurisano, G. Zardini, P. Confalonieri, G. Airaghi, R. Mantegazza, and R. Spreafico Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis Neurology 51 1998 302 305
2. Commission on Classification and Terminology of the International League Against Epilepsy, 1989. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 30, 389-399.
3. S.A. Dambinova, G.A. Khounteev, G.A. Izykenova, I.G. Zavolokov, A.Y. Ilyukhina, and A.A. Skoromets Blood test detecting autoantibodies to N-methyl-d-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke Clin. Chem. 49 2003 1752 1762
4. L.A. DeGiorgio, K.N. Konstantinov, S.C. Lee, J.A. Hardin, B.T. Volpe, and B. Diamond A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus Nat. Med. 7 2001 1189 1193
5. O. Dulac, C. Soufflet, C. Chiron, and A. Kaminska What is west syndrome? Int. Rev. Neurobiol. 49 2002 1 22
6. E. Eilat, M. Dayan, H. Zinger, and E. Mozes The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus Proc. Natl. Acad Sci. U.S.A. 98 2001 1148 1153
7. Y. Ganor, M. Besser, N. Ben-Zakay, T. Unger, and M. Levite Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration J. Immunol. 170 2003 4362 4372
8. Y. Ganor, H. Goldberg-Stern, D. Amrom, T. Lerman-Sagie, V.I. Teichberg, D. Pelled, A.H. Futerman, B. Ben-Zeev, M. Freilinger, D. Verheulpen, P. Van Bogaert, and M. Levite Autoimmune epilepsy: some epilepsy patients harbor autoantibodies to glutamate receptors and dsDNA on both sides of the blood-brain barrier, which may kill neurons and decrease in brain fluids after hemispherotomy Clin. Dev. Immunol. 11 2004 241 252
9. Ganor, Y., Freilinger, M., Dulac, O., Levite, M., 2005a Monozygotic twins discordant for epilepsy differ in the levels of potentially pathogenic autoantibodies and cytokines. Autoimmunity, in press.
10. Ganor, Y., Goldberg-Stern, H., Blank, M., Shoenfeld, Y., Dobrynina, L.A., Kalashnikova, L., Levite, M., 2005b. Antibodies to glutamate receptor subtype 3 (GluR3) are found in some patients suffering from epilepsy as the main disease, but not in patients whose epilepsy accompanies antiphospholipid syndrome or sneddon's syndrome. Autoimmunity (revised).
11. Ganor, Y., Gottlieb, M., Eilam, R., Otmy, H., Teichberg, V.I., Levite, M., 2005c. Immunization with the glutamate receptor derived peptide GluR3B induces neuronal death and reactive gliosis, but confers partial protection from pentylenetetrazole-induced seizures. Exp. Neurol. (in press).
12. T. Granata, L. Fusco, G. Gobbi, E. Freri, F. Ragona, G. Broggi, R. Mantegazza, L. Giordano, F. Villani, G. Capovilla, F. Vigevano, B.D. Bernardina, R. Spreafico, and C. Antozzi Experience with immunomodulatory treatments in Rasmussen's encephalitis Neurology 61 2003 1807 1810
13. B.H. Hahn Antibodies to DNA N. Engl. J. Med. 338 1998 1359 1368
14. X.P. He, M. Patel, K.D. Whitney, S. Janumpalli, A. Tenner, and J.O. McNamara Glutamate receptor GluR3 antibodies and death of cortical cells Neuron 20 1998 153 163
15. E.S. Husebye, Z.M. Sthoeger, M. Dayan, H. Zinger, D. Elbirt, M. Levite, and E. Mozes Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus Ann. Rheum. Dis. 11 2005 11
16. E. Koustova, Y. Sei, L. Fossom, M.L. Wei, P.N. Usherwood, N.B. Keele, M.A. Rogawski, and A.S. Basile LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor J. Clin. Invest. 107 2001 737 744
17. K. Lascelles, A.F. Dean, and R.O. Robinson Rasmussen's encephalitis followed by lupus erythematosus Dev. Med. Child Neurol. 44 2002 572 574
18. M. Levite Autoimmune epilepsy Nat. Immunol. 3 2002 500
19. M. Levite, L.A. Fleidervish, A. Schwarz, D. Pelled, and A.H. Futerman Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel J. Autoimmun. 13 1999 61 72
20. M. Levite, and I.K. Hart Immunotherapy for epilepsy Expert Rev. Neurother. 2 2002 804 819
21. R. Mantegazza, P. Bernasconi, F. Baggi, R. Spreafico, F. Ragona, C. Antozzi, G. Bernardi, and T. Granata Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures J. Neuroimmunol. 131 2002 179 185
22. T. Rasmussen, J. Olszewski, and D. Lloydsmith Focal seizures due to chronic localized encephalitis Neurology 8 1958 435 445
23. S.W. Rogers, P.I. Andrews, L.C. Gahring, T. Whisenand, K. Cauley, B. Crain, T.E. Hughes, S.F. Heinemann, and J.O. McNamara Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis Science 265 1994 648 651
24. L. Seiden, and A. Krumholtz Inflammatory noninfectious disorders A.B. Ettinger O. Devinsky Managing Epilepsy and Co-existing Disorders 2002 Butterworth/Heinemann Boston 135 154
25. Y. Takahashi, H. Mori, M. Mishina, M. Watanabe, T. Fujiwara, J. Shimomura, H. Aiba, T. Miyajima, Y. Saito, A. Nezu, H. Nishida, K. Imai, N. Sakaguchi, and N. Kondo Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua Neurology 61 2003 891 896
26. E. Toubi, M.A. Khamashta, A. Panarra, and G.R. Hughes Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus Am. J. Med. 99 1995 397 401
27. R.E. Twyman, L.C. Gahring, J. Spiess, and S.W. Rogers Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site Neuron 14 1995 755 762
28. K.D. Whitney, and J.O. McNamara GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins J. Neurosci. 20 2000 7307 7316
29. H. Wiendl, C.G. Bien, P. Bernasconi, B. Fleckenstein, C.E. Elger, J. Dichgans, R. Mantegazza, and A. Melms GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis Neurology 57 2001 1511 1514