Diagnostic potential of the NMDA receptor peptide assay for acute ischemic stroke

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Dambinova, Svetlana A ^a   Bettermann, Kerstin ^b   Glynn, Theodore ^c   Tews, Matthew ^c   Olson, David ^d   Weissman, Joseph D ^d   Sowell, Richard L ^a  

^a KENNESAW STATE UNIVERSITY   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d DeKalb Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NMDA RECEPTOR 2 PEPTIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; BRAIN CORTEX LESION; BRAIN ISCHEMIA; BRAIN RADIOGRAPHY; CLINICAL OBSERVATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PEPTIDE ANALYSIS; PREDICTIVE VALUE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; RECEIVER OPERATING CHARACTERISTIC; RECEPTOR UPREGULATION; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SYMPTOM; TRANSIENT ISCHEMIC ATTACK;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; RECEPTORS, N-METHYL-D-ASPARTATE; STROKE; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 84864402371     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042362     Document Type: Article

References (20)

1. Hand PJ, Kwan J, Lindley RI, Dennis MS, Wardlaw JM,((2006)) Distinguishing between stroke and mimic at the bedside. The brain attack study. Stroke 37:: 769--775.
2. Hemmen TM, Meyer BC, McClean TL, Lyden PD,((2008)) Identification of nonischemic stroke mimics among 411 code strokes at the University of California, San Diego, Stroke Center. J Stroke Cerebrovasc Dis 17:: 23--25.
3. Vroomen PC, Buddingh MK, Luijckx GJ, De Keyser J,((2008)) The incidence of stroke mimics among stroke department admissions in relation to age group. J Stroke Cerebrovasc Dis 17:: 418--422.
4. von Kummer R, Nolte PN, Schnittger H, Thron A, Ringelstein EB,((1996)) Detect ability of cerebral hemisphere ischemic infarcts by CT within 6 h of stroke. Neuroradiol 38:: 31--33.
5. Hand PJ, Wardlaw JM, Rowat AM, Haisma JA, Lindley RI, et al.((2005)) Magnetic resonance brain imaging in patients with acute stroke: feasibility and patient related difficulties. J Neurol Neurosurg Psychiatry 76:: 1525--1527.
6. Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P,((2003)) Stroke. Lancet 362:: 1211--1224.
7. Whiteley W, Tian Y, Jickling C,((2012)) Blood biomarkers in stroke: research and clinical practice. Int J Stroke 7:: 435--439.
8. Hasan N, McColgan P, Bentley P, Edwards RJ, Sharma P,((2012)) Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review. Br J Clin Pharmacol 124:: 92--101.
9. Coutts SB, Simon JE, Eliasziw M,((2005)) Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging. Ann Neurol 57:: 848--854.
10. Eng J (2007) ROC Analysis: Web-based calculator for ROC Curves. Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University, Baltimore, Maryland, USA. Available: http://www.rad.jhmi.edu/jeng/javarad/roc/JROCFITi.html. Accessed 2012 Jul 8.
11. Dambinova SA, Khounteev GA, Izykenova GA, Zavolokov IG, Ilyukhina AY, et al.((2003)) Blood test detecting autoantibodies to NMDA neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem 49:: 1752--1762.
12. Bettermann K,((2011)) Biomarkers for stroke: in search of fingerprints. J Stroke Cerebrovasc Dis 20:: 173--176.
13. Betzen C, White R, Zehendner CM, Pietrowski E, Bender B, et al.((2009)) Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium. Free Radical Biol Med 47:: 1212--1220.
14. Sharp CD, Fowler M, Jackson TH, Houghton J, Warren A, et al.((2003)) Human neuroepithelial cells express NMDA receptors. BMC Neurosci 4:: 28--32.
15. Dambinova SA,((2008)) Biomarkers for transient ischemic attack and ischemic stroke. Clin Lab Int 32:: 7--10.
16. Gappoeva MU, Izykenova GA, Granstrem OK, Dambinova SA,((2003)) NMDA receptor mRNA expression in experimental ischemia. Biokhimia 68:: 696--702.
17. Weissman JD, Khunteev GA, Dambinova SA,((2012)) Biomarkers in acute stroke. MAG J 3:: 20--22.
18. Dambinova SA,((2012)) Neurodegradomics: the source of biomarkers for mild traumatic brain injury. In: Biomarkers for TBI. Dambinova SA, Hayes RL, Wang KW, editors. London: RSC Publishing. pp pp. 66--86.
19. Weissman JD, Khunteev GA, Heath R, Dambinova SA,((2011)) NR2 antibodies: Risk assessment of transient ischemic attack (TIA)/stroke in patients with history of isolated and multiple cerebrovascular events. J Neurol Sci 300:: 97--102.
20. An H, Ford AL, Eldeniz C, Yang Y, Chen Y, et al.((2011)) Operatively defined ischemic core, penumbra and oligemia in human acute stroke using sequential MR perfusion images. Proc Intl Soc Mag Reson Med 19:: 463.