Progress in ‘body-on-a-chip’ research

Archives of Toxicology

Volumn 88, Issue 11, 2014, Pages 1913-1914

  Kelm, Jens M ^a   Marchan, Rosemarie ^b  

^a InSphero AG   (Switzerland)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYPHOSPHAMIDE; ALDOPHOSPHAMIDE; CYCLOPHOSPHAMIDE; DRUG METABOLITE; PHOSPHORAMIDE MUSTARD; UNCLASSIFIED DRUG;

BODY ON A CHIP; CANCER TISSUE; CELL CULTURE; CELLS BY BODY ANATOMY; CULTURE TECHNIQUE; EDITORIAL; GRAVITY; HUMAN; IN VITRO STUDY; LAMINAR FLOW; LIVER METABOLISM; MEDICAL RESEARCH; PREDICTION; TISSUE STRUCTURE; TOXICOKINETICS; LAB ON A CHIP; MICROFLUIDIC ANALYSIS; TRENDS;

BIOMEDICAL RESEARCH; CELL CULTURE TECHNIQUES; HUMANS; LAB-ON-A-CHIP DEVICES; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 84919646143     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1353-0     Document Type: Editorial

References (29)

1. Balmer NV, Klima S, Rempel E et al (2014) From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol 88(7):1451–1468. doi:10.1007/s00204-014-1279-6
2. Bolt HM (2011) Regulatory toxicology. EXCLI J 10:138–139
3. Choucha-Snouber L et al (2013) Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip. Biotechnol Bioeng 110:597–608
4. Drasdo D, Hoehme S, Hengstler JG (2014) How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis. J Hepatol. doi:10.1016/j.jhep.2014.06.013
5. Driessen M, Kienhuis AS, Pennings JL et al (2013) Mathematical modelling of liver regeneration after intoxication with CCl(4). Arch Toxicol 87(5):807–823
6. Esch MB, Smith AS, Prot JM et al (2014) How multi-organ microdevices can help foster drug development. Adv Drug Deliv Rev 69–70:158–169. doi:10.1016/j.addr.2013.12.003
7. Fabian E, Vogel D, Blatz V et al (2013) Xenobiotic metabolizing enzyme activities in cells used for testing skin sensitization in vitro. Arch Toxicol 87(9):1683–1696
8. Frey O, Misun PM, Fluri DA et al (2014) Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis. Nat Commun 30(5):4250
9. Ghallab A (2013) In vitro test systems and their limitations. EXCLI J 12:1024–1026
10. Godoy P (2011) Hepatotoxicity. EXCLI J 10:124–127
11. Godoy P, Hengstler JG, Ilkavets I et al (2009) Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology 49(6):2031–2043
12. Godoy P, Hewitt NJ, Albrecht U et al (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 87(8):1315–1530
13. Hammad S, Marchan R, Hengstler JG (2013) Cutting-edge topics in research on animal sciences. J Exp Appl Anim Sci 1(1):1–3
14. Hammad S, Hoehme S, Friebel A et al (2014) Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis. Arch Toxicol 88(5):1161–1183
15. Hengstler JG, Godoy P, Bolt HM (2009) The dilemma of cultivated hepatocytes. Arch Toxicol 83(2):101–103
16. Hoehme S, Hengstler JG, Brulport M et al (2007) Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling. Chem Biol Interact 168(1):74–93
17. Hoehme S, Brulport M, Bauer A et al (2010) Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration. Proc Natl Acad Sci USA 107(23):10371–10376
18. Huh D, Torisawa Y, Hamilton GA et al (2012) Microengineered physiological biomimicry: organs-on-chips. Lab Chip 12:2156–2164
19. Imura Y, Sato K, Yoshimura E (2010) Micro total bioassay system for ingested substances: assessment of intestinal absorption, hepatic metabolism, and bioactivity. Anal Chem 82:9983–9988
20. Krug AK, Kolde R, Gaspar JA et al (2013) Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol 87(1):123–143
21. Messner S, Agarkova I, Moritz W, Kelm JM (2013) Multi-cell type human liver microtissues for hepatotoxicity testing. Arch Toxicol 87(1):209–213
22. Schug M, Stöber R, Heise T et al (2013) Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes. Arch Toxicol 87(2):337–345
23. Sin A et al (2004) The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors. Biotechnol Prog 20:338–345
24. Sonntag F et al (2010) Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure. J Biotechnol 148:70–75
25. Strikwold M, Spenkelink B, Woutersen RA et al (2013) Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human. Arch Toxicol 87(9):1709–1723. doi:10.1007/s00204-013-1107-4
26. Sung JH, Shuler ML (2010) In vitro microscale systems for systematic drug toxicity study. Bioprocess Biosyst Eng 33:5–19
27. Wagner I et al (2013) A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. Lab Chip 13:3538–3547
28. Zhang C, Zhao Z, Abdul Rahim NA et al (2009) Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. Lab Chip 9:3185–3192
29. Zimmer B, Pallocca G, Dreser N et al (2014) Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery. Arch Toxicol 88(5):1109–1126