Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human

Archives of Toxicology

Volumn 87, Issue 9, 2013, Pages 1709-1723

  Strikwold, Marije ^a,b   Spenkelink, Bert ^a   Woutersen, Ruud A ^a,c   Rietjens, Ivonne M C M ^a   Punt, Ans ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b VAN HALL LARENSTEIN UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Alternative for animal testing; Embryonic stem cell test (EST); In vitro in vivo (IVIV) extrapolation; Phenol; Physiologically based kinetic (PBK) modelling; Risk assessment

Indexed keywords

PHENOL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; DOSIMETRY; EMBRYONIC STEM CELL; EMBRYOTOXICITY; GLUCURONIDATION; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SULFATION;

ANIMALIA; RATTUS;

ANIMAL USE ALTERNATIVES; ANIMALS; BIOTRANSFORMATION; CELL DIFFERENTIATION; CELL LINE; CYTOSOL; DISINFECTANTS; EMBRYONIC STEM CELLS; FEMALE; HUMANS; KINETICS; LIVER; MALE; MICE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; ORGAN SPECIFICITY; PHENOL; RATS; RISK ASSESSMENT; SPECIES SPECIFICITY; TERATOGENS;

EID: 84883561097     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1107-4     Document Type: Article

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