Clinically-relevant cyclosporin and rapamycin concentrations enhance regulatory T cell function to a similar extent but with different mechanisms: An in-vitro study in healthy humans

International Immunopharmacology

Volumn 24, Issue 2, 2015, Pages 276-284

  Fanigliulo, Daniela ^a   Lazzerini, Pietro Enea ^b   Capecchi, Pier Leopoldo ^b   Ulivieri, Cristina ^a   Baldari, Cosima Tatiana ^a   Laghi Pasini, Franco ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY HOSPITAL OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; MYCOPHENOLIC ACID; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3; WINGED HELIX TRANSCRIPTION FACTOR; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MIXED LYMPHOCYTE REACTION; NORMAL HUMAN; PHENOTYPE; PROTEIN EXPRESSION; QUALITATIVE RESEARCH; QUANTITATIVE STUDY; REGULATORY T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; METABOLISM; MIXED LYMPHOCYTE CULTURE; TRANSPLANTATION TOLERANCE;

CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CYCLOSPORINE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE CULTURE TEST, MIXED; MYCOPHENOLIC ACID; SIROLIMUS; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE;

EID: 84919608030     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.12.021     Document Type: Article

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