메뉴 건너뛰기




Volumn 25, Issue 3, 2010, Pages 710-717

Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs

Author keywords

Cyclosporine A; Rapamycin; Suppressive functions; TGF ; Treg cells

Indexed keywords

BASILIXIMAB; CD122 ANTIBODY; CD3 ANTIBODY; CD4 ANTIBODY; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2 RECEPTOR ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY GITR; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 77649217359     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp586     Document Type: Article
Times cited : (54)

References (23)
  • 1
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell 2008; 133: 775-787
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3
  • 2
    • 33750008921 scopus 로고    scopus 로고
    • Regulatory T cells and transplantation tolerance
    • Jiang S, Lechler RI, He XS, et al. Regulatory T cells and transplantation tolerance. Hum Immunol 2006; 67: 765-776
    • (2006) Hum Immunol , vol.67 , pp. 765-776
    • Jiang, S.1    Lechler, R.I.2    He, X.S.3
  • 3
    • 37349068519 scopus 로고    scopus 로고
    • Rapamycin-conditioned, alloan-tigen-pulsed dendritic cells promote indefinite survival of vascular-ized skin allografts in association with T regulatory cell expansion
    • Horibe EK, Sacks J, Unadkat J, et al. Rapamycin-conditioned, alloan-tigen-pulsed dendritic cells promote indefinite survival of vascular-ized skin allografts in association with T regulatory cell expansion. Transpl Immunol 2008; 18: 307-318
    • (2008) Transpl Immunol , vol.18 , pp. 307-318
    • Horibe, E.K.1    Sacks, J.2    Unadkat, J.3
  • 4
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-condi-tioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist HR, Raimondi G, Zahorchak AF, et al. Rapamycin-condi-tioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007; 178: 7018-7031
    • (2007) J Immunol , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3
  • 5
    • 34250156673 scopus 로고    scopus 로고
    • Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
    • Gao W, Lu Y, El Essawy B, et al. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007; 7: 1722-1732
    • (2007) Am J Transplant , vol.7 , pp. 1722-1732
    • Gao, W.1    Lu, Y.2    El Essawy, B.3
  • 6
    • 36249005633 scopus 로고    scopus 로고
    • Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates
    • Bestard O, Cruzado JM, Mestre M, et al. Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates. J Immunol 2007; 179: 4901-4909
    • (2007) J Immunol , vol.179 , pp. 4901-4909
    • Bestard, O.1    Cruzado, J.M.2    Mestre, M.3
  • 7
    • 32844455802 scopus 로고    scopus 로고
    • Contrasting CD25hiCD4+ T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance
    • Louis S, Braudeau C, Giral M, et al. Contrasting CD25hiCD4+ T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance. Transplantation 2006; 81: 398-407
    • (2006) Transplantation , vol.81 , pp. 398-407
    • Louis, S.1    Braudeau, C.2    Giral, M.3
  • 8
    • 33749336778 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cell therapy for the induction of donor-specific clinical transplantation tolerance
    • Jiang S, Lechler RI, He XS, et al. CD4+CD25+ regulatory T cell therapy for the induction of donor-specific clinical transplantation tolerance. Expert Opin Biol Ther 2006; 6: 1003-1009
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 1003-1009
    • Jiang, S.1    Lechler, R.I.2    He, X.S.3
  • 9
    • 41149178744 scopus 로고    scopus 로고
    • Impact of immunosup-pressive drugs on CD4+CD25+FOXP3+ regulatory T cells: Does in vitro evidence translate to the clinical setting?
    • Demirkiran A, Hendrikx TK, Baan CC, et al. Impact of immunosup-pressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting? Transplantation 2008; 85: 783-789
    • (2008) Transplantation , vol.85 , pp. 783-789
    • Demirkiran, A.1    Hendrikx, T.K.2    Baan, C.C.3
  • 10
    • 34047130792 scopus 로고    scopus 로고
    • Rapamycin enriches for CD4(+) CD25(+) CD27(+) Foxp3(+) regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple sclerosis
    • Keever-Taylor CA, Browning MB, Johnson BD, et al. Rapamycin enriches for CD4(+) CD25(+) CD27(+) Foxp3(+) regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple sclerosis. Cytotherapy 2007; 9: 144-157
    • (2007) Cytotherapy , vol.9 , pp. 144-157
    • Keever-Taylor, C.A.1    Browning, M.B.2    Johnson, B.D.3
  • 11
    • 8344275995 scopus 로고    scopus 로고
    • Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    • Yagi H, Nomura T, Nakamura K, et al. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 2004; 16: 1643-1656
    • (2004) Int Immunol , vol.16 , pp. 1643-1656
    • Yagi, H.1    Nomura, T.2    Nakamura, K.3
  • 12
    • 42249109013 scopus 로고    scopus 로고
    • Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells
    • Long SA, Buckner JH. Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells. J Autoimmun 2008; 30: 293-302
    • (2008) J Autoimmun , vol.30 , pp. 293-302
    • Long, S.A.1    Buckner, J.H.2
  • 13
    • 46949088630 scopus 로고    scopus 로고
    • De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
    • Kang J, Huddleston SJ, Fraser JM, et al. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J Leukoc Biol 2008; 83: 1230-1239
    • (2008) J Leukoc Biol , vol.83 , pp. 1230-1239
    • Kang, J.1    Huddleston, S.J.2    Fraser, J.M.3
  • 14
    • 33745861719 scopus 로고    scopus 로고
    • Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells
    • Valmori D, Tosello V, Souleimanian NE, et al. Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells. J Immunol 2006; 177: 944-949
    • (2006) J Immunol , vol.177 , pp. 944-949
    • Valmori, D.1    Tosello, V.2    Souleimanian, N.E.3
  • 15
    • 35748956420 scopus 로고    scopus 로고
    • Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
    • Kopf H, de la Rosa GM, Howard OM, et al. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int Immunopharmacol 2007; 7: 1819-1824
    • (2007) Int Immunopharmacol , vol.7 , pp. 1819-1824
    • Kopf, H.1    De La Rosa, G.M.2    Howard, O.M.3
  • 16
    • 0033983617 scopus 로고    scopus 로고
    • Differential anti-inflammatory effects of immunosuppressive drugs: Cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production
    • Attur MG, Patel R, Thakker G, et al. Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production. Inflamm Res 2000; 49: 20-26
    • (2000) Inflamm Res , vol.49 , pp. 20-26
    • Attur, M.G.1    Patel, R.2    Thakker, G.3
  • 17
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y, Borde M, Heissmeyer V, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006; 126: 375-387
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3
  • 18
    • 2942532501 scopus 로고    scopus 로고
    • Costimulation via glu-cocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells
    • Kanamaru F, Youngnak P, Hashiguchi M, et al. Costimulation via glu-cocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol 2004; 172: 7306-7314
    • (2004) J Immunol , vol.172 , pp. 7306-7314
    • Kanamaru, F.1    Youngnak, P.2    Hashiguchi, M.3
  • 19
    • 33947667952 scopus 로고    scopus 로고
    • GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function
    • Bushell A, Wood K. GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function. Am J Transplant 2007; 7: 759-768
    • (2007) Am J Transplant , vol.7 , pp. 759-768
    • Bushell, A.1    Wood, K.2
  • 20
    • 34447295692 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ indirect alloreactive T cells from renal transplant patients suppress both the direct and indirect pathways of allorecognition
    • Spadafora-Ferreira M, Caldas C, Fae KC, et al. CD4+CD25+Foxp3+ indirect alloreactive T cells from renal transplant patients suppress both the direct and indirect pathways of allorecognition. Scand J Immunol 2007; 66: 352-361
    • (2007) Scand J Immunol , vol.66 , pp. 352-361
    • Spadafora-Ferreira, M.1    Caldas, C.2    Fae, K.C.3
  • 21
    • 0036901716 scopus 로고    scopus 로고
    • Basiliximab-sirolimus-pred-nisone induction regimen followed by delayed low-dose cyclosporine in renal transplant recipients of living donors
    • Langer RM, Hong DM, Katz SM, et al. Basiliximab-sirolimus-pred-nisone induction regimen followed by delayed low-dose cyclosporine in renal transplant recipients of living donors. Transplant Proc 2002; 34: 3162-3164
    • (2002) Transplant Proc , vol.34 , pp. 3162-3164
    • Langer, R.M.1    Hong, D.M.2    Katz, S.M.3
  • 22
    • 44849106530 scopus 로고    scopus 로고
    • How many mechanisms do regulatory T cells need?
    • Vignali D. How many mechanisms do regulatory T cells need? Eur J Immunol 2008; 38: 908-911
    • (2008) Eur J Immunol , vol.38 , pp. 908-911
    • Vignali, D.1
  • 23
    • 44849096534 scopus 로고    scopus 로고
    • Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg
    • Horwitz DA, Zheng SG, Wang J, et al. Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg. Eur J Immunol 2008; 38: 912-915
    • (2008) Eur J Immunol , vol.38 , pp. 912-915
    • Horwitz, D.A.1    Zheng, S.G.2    Wang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.