In vivo expression of transforming growth factor-β1 in humans: Stimulation by cyclosporine

Transplantation

Volumn 65, Issue 3, 1998, Pages 313-318

  Shin, Gyu Tae ^a,b   Khanna, Ashwani ^a,c   Ding, Ruchuang ^a   Sharma, Vijay K ^a   Lagman, Milagros ^a   Li, Baogui ^a   Suthanthiran, Manikkam ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b Ajou University Medical Center   (South Korea)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY DONOR; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LIVING DONOR; MONONUCLEAR CELL; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

CYCLOSPORINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-6; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; LIVING DONORS; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032519407     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199802150-00003     Document Type: Article

References (35)

1. Kahan BD. Cyclosporine. N Engl J Med 1989; 321: 1725.
2. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807.
3. Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992; 357: 695.
4. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci USA 1992; 89: 3686.
5. Schreiber SC. Immunophilin-sensitive protein phosphatase activation in cell signalling pathways. Cell 1992; 70: 365.
6. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA. FK 506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 1992; 357: 692.
7. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997; 15: 707.
8. Li B, Sehajpal PK, Khanna A, Vlassara H, Cerami A, Stenzel KH, Suthanthiran M. Differential regulation of transforming growth factor beta and interleukin-2 genes in human T-cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction. J Exp Med 1991; 174: 1259.
9. Prashar Y, Khanna A, Sehajpal P, Sharma VK, Suthanthiran M. Stimulation of transforming growth factor-β transcription by cyclosporine. FEBS Lett 1995; 358: 109.
10. Khanna A, Li B, Stenzel KH, Suthanthiran M. Regulation of new DNA synthesis in mammalian cells by cyclosporine: demonstration of a transforming growth factor β dependent mechanism of inhibition of cell growth. Transplantation 1994; 57: 577.
11. Moore KW. Interleukin-10. Annu Rev Immunol 1993; 11: 165.
12. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol 1990; 8: 253.
13. Smith KA. Interleukin-2: inception, impact, and implications. Science 1988; 240: 1169.
14. Vassalli P. The pathophysiology of tumor necrosis factors. Annu Rev Immunol 1992; 10: 411
15. Granelli-Piperno A, Andrus L, Steinman RM. Lymphokine and nonlymphokine mRNA levels in stimulated human T cells: kinetics, mitogen requirements and effects of cyclosporine A. J Exp Med 1986; 163: 922.
16. Walz G, Zanker B, Melton LB, Suthanthiran M, Strom TB. Possible association of the immunosuppressive and B cell lymphoma-promoting properties of cyclosporine. Transplantation 1990; 49: 191
17. Kinkhabwala M, Sehajpal P, Skolnik E, et al. A novel addition to the T cell repertory: cell-surface expression of tumor necrosis factor/cachectin by activated normal human T cells. J Exp Med 1990; 171: 941.
18. Cohen SBA, Parry SL, Feldmann M, Foxwell B. Autocrine and paracrine regulation of human T cell IL-10 production. J Immunol 1997; 158: 5596.
19. Kehrl JH, Wakefield LM, Roberts AB, et al. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 1986; 163: 1037
20. Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 1993; 8: 1.
21. Border WA, Nobel NA. Transforming growth factor-β in tissue fibrosis. N Engl J Med 1994; 331: 1286.
22. Kulkarni AB, Huh CG, Becher D, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90: 770
23. 1 in knockout and transgenic mouse models. Kidney Int 1997; 5: 1355.
24. Eskdale J, Kube D, Gallagher G. A second polymorphic dinucleotide repeat in the 5′-flanking region of the human IL-10 gene. Immunogenetics 1996; 45: 82.
25. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24: 1.
26. 1 gene in relation to myocardial infarction and blood pressure. Hypertension 1996; 28: 881.
27. 1 in mice: stimulation by cyclosporine. Transplantation 1997; 63: 1037.
28. Durez P, Abramowicz D, Gerard C, et al. In vivo induction of interleukin-10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: differential modulation by cyclosporin A. J Exp Med 1993; 177: 551.
29. Sehajpal PK, Sharma VK, Ingulli E, Stenzel KH, Suthanthiran M. Synergism between the CD3 antigen- and CD2 antigen-derived signals: exploration at the level of induction of DNA-binding proteins and characterization of the inhibitory activity of cyclosporine. Transplantation 1993; 55: 1118.
30. Larson TG, Nuss DL. Cyclophilin-dependent stimulation of transcription by cyclosporin A. Proc Natl Acad Sci USA 1993; 90: 148.
31. Kube D, Platzer C, von Kuethen A, et al. Isolation of the human interleukin-10 promoter: characterization of the promoter activity in Burkitt's lymphoma cell lines. Cytokine 1995; 7: 1.
32. Weinberg RA. E2F and cell proliferation: a world turned upside down. Cell 1996; 85: 457.
33. Kurihara H, Yoshizumi M, Sugiyama T, et al. Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun 1989; 159: 1435.
34. Weiner HL, Friedman A, Miller A, et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 1994; 12: 809.
35. Itoh K, Hirohata S. The role of IL-10 in human B cell activation, proliferation, and differentiation. J Immunol 1995; 154: 4341.