Cyclosporin A reduces CD4+CD25+ regulatory T-cell numbers in patients with atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 124, Issue 4, 2009, Pages 856-858

  Hijnen, DirkJan ^a   Haeck, Inge ^a   van Kraats, Annemieke A ^a   Nijhuis, Evert ^a   de Bruin Weller, Marjolein S ^a   Bruijnzeel Koomen, Carla A F M ^a   Knol, Edward F ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CYCLOSPORIN A; IMMUNOGLOBULIN E; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; CYCLOSPORIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT;

ADULT; ANTIGEN EXPRESSION; ATOPIC DERMATITIS; BLOOD ANALYSIS; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LETTER; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SCORING SYSTEM; THYMUS; CD4 LYMPHOCYTE COUNT; IMMUNOLOGY; METABOLISM; MIDDLE AGED;

ADULT; CD4 LYMPHOCYTE COUNT; CYCLOSPORINE; DERMATITIS, ATOPIC; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; T-LYMPHOCYTES, REGULATORY;

EID: 70449710917     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.07.056     Document Type: Letter

References (8)

1. Baan C.C., van der Mast B.J., Klepper M., Mol W.M., Peeters A.M., Korevaar S.S., et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 80 (2005) 110-117
2. Mantel P.Y., Ouaked N., Ruckert B., Karagiannidis C., Welz R., Blaser K., et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 176 (2006) 3593-3602
3. Zeiser R.S., Nguyen V.H., Beilhack A., Buess M., Schulz S., Baker J., et al. Inhibition of CD4+CD25+ regulatory T cell function by calcineurin dependent interleukin-2 production. Blood 108 (2006) 390-399
4. San S.D., Fabrega E., Lopez-Hoyos M., and Pons F. Reduced numbers of blood natural regulatory T cells in stable liver transplant recipients with high levels of calcineurin inhibitors. Transplant Proc 39 (2007) 2290-2292
5. Ou L.S., Goleva E., Hall C., and Leung D.Y. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 113 (2004) 756-763
6. Han G.M., O'Neil-Andersen N.J., Zurier R.B., and Lawrence D.A. CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol 253 (2008) 92-101
7. van Amelsfort J.M., van Roon J.A., Noordegraaf M., Jacobs K.M., Bijlsma J.W., Lafeber F.P., et al. Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 56 (2007) 732-742
8. Brandt C., Pavlovic V., Radbruch A., Worm M., and Baumgrass R. Low-dose cyclosporine A therapy increases the regulatory T cell population in patients with atopic dermatitis. Allergy (2009) [e-pub ahead of print]