Functional CD25bright+ alloresponsive T cells in fully immunosuppressed renal allograft recipients

Clinical Transplantation

Volumn 21, Issue 1, 2007, Pages 63-71

  Baan, Carla C ^a   Velthuis, Jurjen H L ^a   van Gurp, Evelien A F J ^a   Mol, Wendy M ^a   Klepper, Mariska ^a   Ijzermans, Jan N M ^a   Weimar, Willem ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

CD4+ CD25bright+ regulatory T cells; Kidney transplantation; Patients

Indexed keywords

INTERLEUKIN 2; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PREDNISONE; TACROLIMUS;

ACUTE GRAFT REJECTION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG WITHDRAWAL; HUMAN; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY DONOR; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION TOLERANCE;

ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY TRANSPLANTATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE DEPLETION; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 33846700589     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2006.00584.x     Document Type: Article

References (37)

1. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 Receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995: 155: 1151.
2. +regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001: 182: 18.
3. + suppressor cell and its mechanism of action. J Exp Med 2002: 171: 141.
4. Wood K, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Immunol Rev 2003: 3: 199.
5. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003: 299: 1057.
6. + regulatory T cells. Nat Immunol 2003: 4: 330.
7. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998: 188: 287.
8. Furtado GC, De Lafaille MAC, Kutchukhidze N, Lafaille JJ. Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J Exp Med 2002: 196: 851.
9. + T cell suppressor function. J Immunol 2004: 172: 6519.
10. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function of interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2006: 6: 1142.
11. + regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 2006: 6: 1152.
12. Baan CC, van Emmerik NEM, Balk AHMM et al. Cytokine mRNA expression in endomyocardial biopsies during acute rejection from human heart transplants. Clin Exp Immunol 1994: 97: 293.
13. Suthanthiran M. Clinical application of molecular biology: A study of allograft rejection with polymerase chain reaction. Am J Med Sci 1997: 313: 264.
14. De Groot-Kruseman HA, Baan CC, Hagman EM et al. Intragraft interleukin-2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantation. Heart 2002: 87: 363.
15. + CD25 - cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10. J Immunol 2004: 172: 5213.
16. Baan CC, van der Mast BJ, Klepper M et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 2005: 80: 110.
17. + cells in vitro. Am J Transplant 2005: 5: 454.
18. + regulatory T cells. Blood 2005: 105: 4743.
19. high regulatory cells in human peripheral blood. J Immunol 2001: 167: 1245.
20. bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 2004: 172: 6435.
21. Bluestone JA. Regulatory T-cell therapy: Is it ready for the clinic ? Nat Rev Immunol 2005: 5: 343.
22. Chatila TA. Role of regulatory T cells in human diseases. J Allergy Clin Immunol 2005: 116: 949.
23. + regulatory T cells in tumor immunity. Curr Top Microbiol Immunol 2005: 293: 287.
24. Shi HZ, Qin XJ. CD4CD25 regulatory T lymphocytes in allergy and asthma. Allergy 2005: 60: 986.
25. Graca L, Cobbold SP, Waldmann H. Identification of regulatory T cells in tolerant allografts. J Exp Med 2002: 195: 1641.
26. + regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J Immunol 2004: 172: 6539.
27. Muthukumar T, Dadhania D, Ding R et al. Messenger RNA for FOXP3 in the urine of renal allograft recipients. N Engl J Med 2005: 353: 2342.
28. + regulatory T cells in operational tolerance after living donor liver transplantation. Transplant Proc 2005: 37: 37.
29. + T cells in human kidney transplant recipients. J Am Soc Nephrol 2003: 14: 1643.
30. + regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients. J Am Soc Nephrol 2003: 14: 1652.
31. Jiang H, Chess L. Regulation of immune responses by T cells. N Engl J Med 2006: 354: 1166.
32. Mantel P-Y, Ouaked N, Ruckert B et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 2006: 176: 3593.
33. + regulatory T cells. Blood 2006: 107: 1018.
34. Sikas N, Imvris G, Takoudas D, Gakis D, Papanikolaou V. Mycophenolate Mofetil impairs the integrity of colonic anastomosis. J Surg Res 2006: 134: 168.
35. Lin J-X, Migone T-S, Tsang M et al. The shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 1995: 2: 331.
36. Baan CC, Knoop CJ, van Gelder T et al. Anti-CD25 therapy reveals the redundancy of the intragraft cytokine network after clinical heart transplantation. Transplantation 1999: 67: 870.
37. Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Immunol 2004: 4: 665.