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Volumn 15, Issue 1, 2015, Pages 79-88

Deoxypodophyllotoxin isolated from juniperus communis induces apoptosis in breast cancer cells

Author keywords

Apoptosis; Breast cancer; Caspase; Deoxypodophyllotoxin; ERK; Isocupressic acid; Juniperus communis; NF B

Indexed keywords

CASPASE 3; CASPASE 7; DEOXYPODOPHYLLOTOXIN; ISOCUPRESSIC ACID; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; CARBOXYLIC ACID; CASPASE; DITERPENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PODOPHYLLOTOXIN; TETRALIN DERIVATIVE;

EID: 84919608013     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520614666140608150448     Document Type: Article
Times cited : (49)

References (50)
  • 1
    • 0031945458 scopus 로고    scopus 로고
    • Cell cycle regulation and apoptosis
    • King, K.L.; Cidlowski, J.A. Cell cycle regulation and apoptosis. Annu. Rev. Physiol., 1998, 60, 601-617.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 601-617
    • King, K.L.1    Cidlowski, J.A.2
  • 2
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, D.R.; Reed, J.C. Mitochondria and apoptosis. Science, 1998, 281(5381), 1309-1312.
    • (1998) Science , vol.281 , Issue.5381 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 3
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: Integrating mammalian biology
    • Locksley, R.M.; Killeen, N.; Lenardo, M.J. The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell, 2001, 104(4), 487-501.
    • (2001) Cell , vol.104 , Issue.4 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 4
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi, A.; Dixit, V.M. Death receptors: Signaling and modulation. Science, 1998, 281(5381), 1305-1308.
    • (1998) Science , vol.281 , Issue.5381 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 6
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: Tumour resistance to apoptosis
    • Igney, F.H.; Krammer, P.H. Death and anti-death: Tumour resistance to apoptosis. Nat. Rev. Cancer, 2002, 2(4), 277-288.
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.4 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 7
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li, H.; Zhu, H.; Xu, C.J.; Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 1998, 94(4), 491-501.
    • (1998) Cell , vol.94 , Issue.4 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 8
    • 0032928614 scopus 로고    scopus 로고
    • Mitogenactivated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widmann, C.; Gibson, S.; Jarpe, M.B.; Johnson, G.L. Mitogenactivated protein kinase: Conservation of a three-kinase module from yeast to human. Physiol. Rev., 1999, 79(1), 143-180.
    • (1999) Physiol. Rev. , vol.79 , Issue.1 , pp. 143-180
    • Widmann, C.1    Gibson, S.2    Jarpe, M.B.3    Johnson, G.L.4
  • 9
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon, A.S.; Hagan, S.; Rath, O.; Kolch, W. MAP kinase signalling pathways in cancer. Oncogene, 2007, 26(22), 3279-3290.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 10
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NFkappaB
    • Chen, L.F.; Greene, W.C. Shaping the nuclear action of NFkappaB. Nat. Rev. Mol. Cell Biol., 2004, 5(5), 392-401.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , Issue.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 11
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Suppl
    • Ghosh, S.; Karin, M. Missing pieces in the NF-kappaB puzzle. Cell,2002, 109 Suppl, S81-96.
    • (2002) Cell , vol.109 , pp. S81-S96
    • Ghosh, S.1    Karin, M.2
  • 12
    • 78650621692 scopus 로고    scopus 로고
    • Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics
    • Yap, J.L.; Worlikar, S.; MacKerell, A.D., Jr.; Shapiro, P.; Fletcher, S. Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics. Chem. Med. Chem., 2011, 6(1), 38-48.
    • (2011) Chem. Med. Chem. , vol.6 , Issue.1 , pp. 38-48
    • Yap, J.L.1    Worlikar, S.2    Mackerell, A.D.3    Shapiro, P.4    Fletcher, S.5
  • 13
    • 33646399160 scopus 로고    scopus 로고
    • Targeting the ERK signaling pathway in cancer therapy
    • Kohno, M.; Pouyssegur, J. Targeting the ERK signaling pathway in cancer therapy. Ann. Med.,2006, 38(3), 200-211.
    • (2006) Ann. Med. , vol.38 , Issue.3 , pp. 200-211
    • Kohno, M.1    Pouyssegur, J.2
  • 14
    • 84858718448 scopus 로고    scopus 로고
    • NF-kappaB and the link between inflammation and cancer
    • DiDonato, J.A.; Mercurio, F.; Karin, M. NF-kappaB and the link between inflammation and cancer. Immunol. Rev., 2012, 246(1), 379-400.
    • (2012) Immunol. Rev. , vol.246 , Issue.1 , pp. 379-400
    • Didonato, J.A.1    Mercurio, F.2    Karin, M.3
  • 15
    • 84875495370 scopus 로고    scopus 로고
    • Apoptosis and autophagy induction as mechanism of cancer prevention by naturally occurring dietary agents
    • Mukhtar, E.; Adhami, V.M.; Khan, N.; Mukhtar, H. Apoptosis and autophagy induction as mechanism of cancer prevention by naturally occurring dietary agents. Curr. Drug Targets, 2012, 13(14), 1831-1841.
    • (2012) Curr. Drug Targets , vol.13 , Issue.14 , pp. 1831-1841
    • Mukhtar, E.1    Adhami, V.M.2    Khan, N.3    Mukhtar, H.4
  • 17
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
    • Newman, D.J. Natural products as leads to potential drugs: An old process or the new hope for drug discovery? J. Med. Chem., 2008, 51(9), 2589-2599.
    • (2008) J. Med. Chem. , vol.51 , Issue.9 , pp. 2589-2599
    • Newman, D.J.1
  • 18
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod., 2007, 70(3), 461-477.
    • (2007) J. Nat. Prod. , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 19
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh, Y. J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer, 2003, 3(10), 768-780.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.10 , pp. 768-780
    • Surh, Y.J.1
  • 20
    • 38349000628 scopus 로고    scopus 로고
    • Cancer chemoprevention through dietary antioxidants: Progress and promise
    • Khan, N.; Afaq, F.; Mukhtar, H. Cancer chemoprevention through dietary antioxidants: Progress and promise. Antioxid. Redox. Signal, 2008, 10(3), 475-510.
    • (2008) Antioxid. Redox. Signal , vol.10 , Issue.3 , pp. 475-510
    • Khan, N.1    Afaq, F.2    Mukhtar, H.3
  • 21
    • 84882237620 scopus 로고    scopus 로고
    • Deoxypodophyllotoxin: A promising therapeutic agent from herbal medicine
    • Khaled, M.; Jiang, Z.Z.; Zhang, L.Y. Deoxypodophyllotoxin: A promising therapeutic agent from herbal medicine. J. Ethnopharmacol., 2013, 149(1), 24-34.
    • (2013) J. Ethnopharmacol. , vol.149 , Issue.1 , pp. 24-34
    • Khaled, M.1    Jiang, Z.Z.2    Zhang, L.Y.3
  • 23
    • 9644281587 scopus 로고    scopus 로고
    • Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells
    • Robichaud, G.A.; Nardini, M.; Laflamme, M.; Cuperlovic-Culf, M.; Ouellette, R.J. Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells. J. Biol.Chem., 2004, 279(48), 49956-49963.
    • (2004) J. Biol.Chem. , vol.279 , Issue.48 , pp. 49956-49963
    • Robichaud, G.A.1    Nardini, M.2    Laflamme, M.3    Cuperlovic-Culf, M.4    Ouellette, R.J.5
  • 24
    • 0037189506 scopus 로고    scopus 로고
    • Nuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells
    • Robichaud, G.A.; Barbeau, B.; Fortin, J.F.; Rothstein, D.M.; Tremblay, M.J. Nuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells. J. Biol. Chem., 2002, 277(26), 23733-23741.
    • (2002) J. Biol. Chem. , vol.277 , Issue.26 , pp. 23733-23741
    • Robichaud, G.A.1    Barbeau, B.2    Fortin, J.F.3    Rothstein, D.M.4    Tremblay, M.J.5
  • 25
    • 84856251128 scopus 로고    scopus 로고
    • Traditional use of medicinal plants in the boreal forest of Canada: Review and perspectives
    • Uprety, Y.; Asselin, H.; Dhakal, A.; Julien, N. Traditional use of medicinal plants in the boreal forest of Canada: Review and perspectives. J. Ethnobiol. Ethnomed., 2012, 8, 7.
    • (2012) J. Ethnobiol. Ethnomed. , vol.8
    • Uprety, Y.1    Asselin, H.2    Dhakal, A.3    Julien, N.4
  • 27
    • 0009937024 scopus 로고    scopus 로고
    • Isocupressic acid, an abortifacient component of Cupressus macrocarpa
    • Parton, K.; Gardner, D.; Williamson, N.B. Isocupressic acid, an abortifacient component of Cupressus macrocarpa. N Z Vet J., 1996, 44(3), 109-111.
    • (1996) N Z Vet J. , vol.44 , Issue.3 , pp. 109-111
    • Parton, K.1    Gardner, D.2    Williamson, N.B.3
  • 28
    • 0032869476 scopus 로고    scopus 로고
    • Pine needle abortion in cattle: Metabolism of isocupressic acid
    • Gardner, D.R.; Panter, K.E.; James, L.F. Pine needle abortion in cattle: Metabolism of isocupressic acid. J. Agric. Food. Chem., 1999, 47(7), 2891-2897.
    • (1999) J. Agric. Food. Chem. , vol.47 , Issue.7 , pp. 2891-2897
    • Gardner, D.R.1    Panter, K.E.2    James, L.F.3
  • 29
    • 40449112984 scopus 로고    scopus 로고
    • Isolation of apoptosis-and differentiation-inducing substances toward human promyelocytic leukemia HL-60 cells from leaves of Juniperus taxifolia
    • Muto, N.; Tomokuni, T.; Haramoto, M.; Tatemoto, H.; Nakanishi, T.; Inatomi, Y.; Murata, H.; Inada, A. Isolation of apoptosis-and differentiation-inducing substances toward human promyelocytic leukemia HL-60 cells from leaves of Juniperus taxifolia. Biosci. Biotechnol. Biochem., 2008, 72(2), 477-484.
    • (2008) Biosci. Biotechnol. Biochem. , vol.72 , Issue.2 , pp. 477-484
    • Muto, N.1    Tomokuni, T.2    Haramoto, M.3    Tatemoto, H.4    Nakanishi, T.5    Inatomi, Y.6    Murata, H.7    Inada, A.8
  • 31
    • 72949083280 scopus 로고    scopus 로고
    • Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells
    • Shin, S.Y.; Yong, Y.; Kim, C.G.; Lee, Y.H.; Lim, Y. Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells. Cancer Lett., 2010, 287(2), 231-239.
    • (2010) Cancer Lett. , vol.287 , Issue.2 , pp. 231-239
    • Shin, S.Y.1    Yong, Y.2    Kim, C.G.3    Lee, Y.H.4    Lim, Y.5
  • 32
    • 84875190063 scopus 로고    scopus 로고
    • Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin
    • Kim, K.Y.; Cho, H.J.; Yu, S.N.; Kim, S.H.; Yu, H.S.; Park, Y.M.; Mirkheshti, N.; Kim, S.Y.; Song, C.S.; Chatterjee, B.; Ahn, S.C. Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin. J. Cell Biochem., 2013, 114(5), 1124-1134.
    • (2013) J. Cell Biochem. , vol.114 , Issue.5 , pp. 1124-1134
    • Kim, K.Y.1    Cho, H.J.2    Yu, S.N.3    Kim, S.H.4    Yu, H.S.5    Park, Y.M.6    Mirkheshti, N.7    Kim, S.Y.8    Song, C.S.9    Chatterjee, B.10    Ahn, S.C.11
  • 33
    • 84879289875 scopus 로고    scopus 로고
    • Anthricin isolated from anthriscus sylvestris (l.) hoffm. Inhibits the growth of breast cancer cells by inhibiting akt/mtor signaling, and its apoptotic effects are enhanced by autophagy inhibition
    • 385219
    • Jung, C.H.; Kim, H.; Ahn, J.; Jung, S.K.; Um, M.Y.; Son, K.H.; Kim, T.W.; Ha, T.Y. Anthricin isolated from anthriscus sylvestris (l.) hoffm. Inhibits the growth of breast cancer cells by inhibiting akt/mtor signaling, and its apoptotic effects are enhanced by autophagy inhibition. Evid. Based Complement Alternat. Med., 2013, 2013, 385219.
    • (2013) Evid. Based Complement Alternat. Med. , vol.2013
    • Jung, C.H.1    Kim, H.2    Ahn, J.3    Jung, S.K.4    Um, M.Y.5    Son, K.H.6    Kim, T.W.7    Ha, T.Y.8
  • 34
    • 67650162734 scopus 로고    scopus 로고
    • Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis
    • Yong, Y.; Shin, S.Y.; Lee, Y.H.; Lim, Y. Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. Bioorg. Med. Chem. Lett., 2009, 19(15), 4367-4371.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , Issue.15 , pp. 4367-4371
    • Yong, Y.1    Shin, S.Y.2    Lee, Y.H.3    Lim, Y.4
  • 37
    • 79958026380 scopus 로고    scopus 로고
    • The Ras-ERK and PI3KmTOR pathways: Cross-talk and compensation
    • Mendoza, M.C.; Er, E.E.; Blenis, J. The Ras-ERK and PI3KmTOR pathways: Cross-talk and compensation. Trends Biochem. Sci., 2011, 36(6), 320-328.
    • (2011) Trends Biochem. Sci. , vol.36 , Issue.6 , pp. 320-328
    • Mendoza, M.C.1    Er, E.E.2    Blenis, J.3
  • 38
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: Of feedbacks and cross-talks
    • Carracedo, A.; Pandolfi, P.P. The PTEN-PI3K pathway: Of feedbacks and cross-talks. Oncogene,2008, 27(41), 5527-5541.
    • (2008) Oncogene , vol.27 , Issue.41 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 40
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein, B.; Lane, D.; Levine, A.J. Surfing the p53 network. Nature,2000, 408(6810), 307-310.
    • (2000) Nature , vol.408 , Issue.6810 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 41
    • 43249104714 scopus 로고    scopus 로고
    • Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells
    • Junk, D.J.; Vrba, L.; Watts, G.S.; Oshiro, M.M.; Martinez, J.D.; Futscher, B.W. Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells. Neoplasia, 2008, 10(5), 450-461.
    • (2008) Neoplasia , vol.10 , Issue.5 , pp. 450-461
    • Junk, D.J.1    Vrba, L.2    Watts, G.S.3    Oshiro, M.M.4    Martinez, J.D.5    Futscher, B.W.6
  • 42
    • 0032910169 scopus 로고    scopus 로고
    • Apoptosis control by death and decoy receptors
    • Ashkenazi, A.; Dixit, V.M. Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol., 1999, 11(2), 255-260.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , Issue.2 , pp. 255-260
    • Ashkenazi, A.1    Dixit, V.M.2
  • 44
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)
    • Ashkenazi, A.; Holland, P.; Eckhardt, S.G. Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). J. Clin. Oncol., 2008, 26(21), 3621-3630.
    • (2008) J. Clin. Oncol. , vol.26 , Issue.21 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 45
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol., 2007, 35(4), 495-516.
    • (2007) Toxicol. Pathol. , vol.35 , Issue.4 , pp. 495-516
    • Elmore, S.1
  • 46
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • Simon, H.U.; Haj-Yehia, A.; Levi-Schaffer, F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis, 2000, 5(5), 415-418.
    • (2000) Apoptosis , vol.5 , Issue.5 , pp. 415-418
    • Simon, H.U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 47
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • Circu, M.L.; Aw, T.Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic. Biol. Med., 2010, 48(6), 749-762.
    • (2010) Free Radic. Biol. Med. , vol.48 , Issue.6 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 48
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner, M.O., The biochemistry of apoptosis. Nature, 2000, 407(6805), 770-776.
    • (2000) Nature , vol.407 , Issue.6805 , pp. 770-776
    • Hengartner, M.O.1
  • 49
    • 81255157503 scopus 로고    scopus 로고
    • Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects
    • Chen, S.W.; Gao, Y.Y.; Zhou, N.N.; Liu, J.; Huang, W.T.; Hui, L.; Jin, Y.; Jin, Y. X. Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects. Bioorg. Med. Chem. Lett., 2011, 21(24), 7355-7358.
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , Issue.24 , pp. 7355-7358
    • Chen, S.W.1    Gao, Y.Y.2    Zhou, N.N.3    Liu, J.4    Huang, W.T.5    Hui, L.6    Jin, Y.7    Jin, Y.X.8
  • 50
    • 78650721191 scopus 로고    scopus 로고
    • Preparation of solid inclusion complex of deoxypodophyllotoxin-SBE-β-CD and its antitumor activity
    • Zhu, X.; Wu, B.J.; Luo, H.W.; Tao, L.; Zhao, Q.; Guo, Q.L.; Wu, C.X. Preparation of solid inclusion complex of deoxypodophyllotoxin-SBE-β-CD and its antitumor activity. J. China Pharm. University, 2010, 41, 447-455.
    • (2010) J. China Pharm. University , vol.41 , pp. 447-455
    • Zhu, X.1    Wu, B.J.2    Luo, H.W.3    Tao, L.4    Zhao, Q.5    Guo, Q.L.6    Wu, C.X.7


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