Anthricin isolated from anthriscus sylvestris (L.) Hoffm. Inhibits the growth of breast cancer cells by inhibiting Akt/mTOR signaling, and its apoptotic effects are enhanced by autophagy inhibition

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Jung, Chang Hwa ^a,b   Kim, Heemun ^a   Ahn, Jiyun ^a,b   Jung, Sung Keun ^a   Um, Min Young ^a   Son, Kun Ho ^c   Kim, Tae Wan ^c   Ha, Tae Youl ^a,b  

^a University of Science and Technology (UST)   (South Korea)

^b Korea Food Research Institute   (South Korea)

^c Andong National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRICIN; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PLANT EXTRACT; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANTHRISCUS SYLVESTRIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER THERAPY; CELL PROLIFERATION; CELL VIABILITY; DRUG ISOLATION; GENE DELETION; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 84879289875     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/385219     Document Type: Article

References (32)

1. Society AC, Cancer Facts & Figures 2011-2013 2013 Atlanta, Ga, USA American Cancer Society
2. Androutsopoulos V., Arroo R. R. J., Hall J. F., Surichan S., Potter G. A., Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Breast Cancer Research 2008 10 3, article R39 2-s2.0-55749110433 10.1186/bcr2090
3. Elamin M. H., Daghestani M. H., Omer S. A., Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food and Chemical Toxicology 2013 53 310 316
4. Choi E. J., Kim G. H., Antiproliferative activity of daidzein and genistein may be related to ER α /c-erbB-2 expression in human breast cancer cells. Molecular Medicine Reports 2013 7 3 781 784 10.3892/mmr.2013.1283
5. Li Y., Chen H., Hardy T. M., Tollefsbol T. O., Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. PLoS ONE 2013 8 1 e54369
6. Athar M., Back J. H., Kopelovich L., Bickers D. R., Kim A. L., Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Archives of Biochemistry and Biophysics 2009 486 2 95 102 2-s2.0-67349128956 10.1016/j.abb.2009.01.018
7. Hendrawati O., Woerdenbag H. J., Hille J., Quax W. J., Kayser O., Seasonal variations in the deoxypodophyllotoxin content and yield of Anthriscus sylvestris L. (Hoffm.) grown in the field and under controlled conditions. Journal of Agricultural and Food Chemistry 2011 59 15 8132 8139 2-s2.0-79961142415 10.1021/jf200177q
8. Jeong G., Kwon O., Park B., Oh S., Ahn K., Chang M., Oh W. K., Kim J., Min B., Kim Y., Lee H., Lignans and coumarins from the roots of Anthriscus sylvestris and their increase of caspase-3 activity in HL-60 cells. Biological and Pharmaceutical Bulletin 2007 30 7 1340 1343 2-s2.0-34447123762 10.1248/bpb.30.1340
9. Kim K. Y., Cho H. J., Yu S. N., Interplay of reactive oxygen species, intracellular Ca(2+) surge and loss of mitochondrial homeostasis in the apoptotic ablation of prostate cancer cells by deoxypodophyllotoxin. Journal of Cellular Biochemistry 2012 10.1002/jcb.24455
10. Muto N., Tomokuni T., Haramoto M., Tatemoto H., Nakanishi T., Inatomi Y., Murata H., Inada A., Isolation of apoptosis- and differentiation-inducing substances toward human promyelocytic leukemia HL-60 cells from leaves of Juniperus taxifolia. Bioscience, Biotechnology and Biochemistry 2008 72 2 477 484 2-s2.0-40449112984 10.1271/bbb.70570
11. Shin S. Y., Yong Y., Kim C. G., Lee Y. H., Lim Y., Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells. Cancer Letters 2010 287 2 231 239 2-s2.0-72949083280 10.1016/j.canlet.2009.06.019
12. Yong Y., Shin S. Y., Lee Y. H., Lim Y., Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: induction of G2/M cell cycle arrest and caspase-dependent apoptosis. Bioorganic and Medicinal Chemistry Letters 2009 19 15 4367 4371 2-s2.0-67650162734 10.1016/j.bmcl.2009. 05.093
13. Baselga J., Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. The oncologist 2011 16 supplement 12 19 2-s2.0-79959508436 10.1634/theoncologist.2011-S1-12
14. García-García C., Ibrahim Y. H., Serra V., Calvo M. T., Guzmán M., Grueso J., Aura C., Pérez J., Jessen K., Liu Y., Rommel C., Tabernero J., Baselga J., Scaltriti M., Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy. Clinical Cancer Research 2012 18 9 2603 2612 2-s2.0-84860532107 10.1158/1078-0432.CCR-11-2750
15. Maycotte P., Thorburn A., Autophagy and cancer therapy. Cancer Biology and Therapy 2011 11 2 127 137 2-s2.0-78751492210 10.4161/cbt.11.2.14627
16. Jung C. H., Jun C. B., Ro S., Kim Y., Otto N. M., Cao J., Kundu M., Kim D., ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Molecular Biology of the Cell 2009 20 7 1992 2003 2-s2.0-65249176304 10.1091/mbc.E08-12-1249
17. Amaral C., Borges M., Melo S., Apoptosis and autophagy in breast cancer cells following exemestane treatment. PLoS ONE 2012 7 8 e42398
18. Kim D.-H., Sarbassov D. D., Ali S. M., King J. E., Latek R. R., Erdjument-Bromage H., Tempst P., Sabatini D. M., mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 110 2 163 175 2-s2.0-0037178786 10.1016/S0092-8674(02)00808-5
19. Stark G. R., Taylor W. R., Control of the G2/M transition. Molecular Biotechnology 2006 32 3 227 248 2-s2.0-33646907207 10.1385/MB:32:3:227
20. Tooze S. A., Jefferies H. B. J., Kalie E., Longatti A., Mcalpine F. E., Mcknight N. C., Orsi A., Polson H. E. J., Razi M., Robinson D. J., Webber J. L., Trafficking and signaling in mammalian autophagy. IUBMB Life 2010 62 7 503 508 2-s2.0-77955879909 10.1002/iub.334
21. Zhou S., Zhao L., Kuang M., Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde? Cancer Letters 2012 323 2 115 127
22. Klionsky D. J., Abdalla F. C., Abeliovich H., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 8 4 445 544
23. Mizushima N., Yoshimori T., How to interpret LC3 immunoblotting. Autophagy 2007 3 6 542 545 2-s2.0-35848967804
24. Xie R., Nguyen S., McKeehan W. L., Liu L., Acetylated microtubules are required for fusion of autophagosomes with lysosomes. BMC Cell Biology 2010 11, article 89 2-s2.0-78549296763 10.1186/1471-2121-11-89
25. Grunt T. W., Mariani G. L., Novel approaches for molecular targeted therapy of breast cancer: interfering with PI3K/AKT/mTOR signaling. Curr Cancer Drug Targets 2013 13 2 188 204
26. Ghadimi M. P., Lopez G., Torres K. E., Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors. Molecular Cancer Therapeutics 2012 11 8 1758 1769
27. Zhang Y., Xu S., Lin J., mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo. Breast Cancer Research and Treatment 2012 136 2 379 388
28. Kim Y., Kim S., You Y., Ahn B., Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana. Planta Medica 2002 68 3 271 274 2-s2.0-0036212896 10.1055/s-2002-23140
29. Kanematsu S., Uehara N., Miki H., Yoshizawa K., Kawanaka A., Yuri T., Tsubura A., Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells. Anticancer Research 2010 30 9 3381 3390 2-s2.0-77958609008
30. Prabhu V., Srivastava P., Yadav N., Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. Mitochondrion 2012 10.1016/j.mito.2012.10.010
31. Malaguti P., Vari S., Cognetti F., Fabi A., The Mammalian target of rapamycin inhibitors in breast cancer: current evidence and future directions. Anticancer Research 2013 33 1 21 28
32. Xie X., White E. P., Mehnert J. M., Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma. PLoS ONE 2013 8 1 e55096