Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors

Blood

Volumn 124, Issue 26, 2014, Pages 3924-3931

  Springuel, Lorraine ^a,b   Hornakova, Tekla ^a,b   Losdyck, Elisabeth ^a,b   Lambert, Fanny ^a,b   Leroy, Emilie ^a,b   Constantinescu, Stefan N ^a,b   Flex, Elisabetta ^c   Tartaglia, Marco ^c   Knoops, Laurent ^a,b,d   Renauld, Jean Christophe ^a,b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOKINE RECEPTOR; JANUS KINASE 1; JANUS KINASE 3; RUXOLITINIB; STAT PROTEIN; JAK1 PROTEIN, MOUSE; JAK3 PROTEIN, MOUSE; JANUS KINASE; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME ACTIVATION; HUMAN; NONHUMAN; POINT MUTATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STABLE EXPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL TRANSFORMATION; CHEMISTRY; GENETICS; HEK293 CELL LINE; MISSENSE MUTATION; MOUSE; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DRUG RESISTANCE, NEOPLASM; HEK293 CELLS; HUMANS; JANUS KINASE 1; JANUS KINASE 3; JANUS KINASES; MICE; MUTATION, MISSENSE; POINT MUTATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; SIGNAL TRANSDUCTION;

EID: 84919474961     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-05-576652     Document Type: Article

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