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Volumn 5, Issue AUG, 2014, Pages

Elicitation of broadly neutralizing antibodies against HIV-1-the germline/maturation hypothesis

Author keywords

Antibody 454; Antibody IgM Germline; HIV 1 vaccine broadly; Neutralizing; Sequencing

Indexed keywords


EID: 84919420520     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00398     Document Type: Article
Times cited : (10)

References (51)
  • 3
    • 84890859441 scopus 로고    scopus 로고
    • Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer
    • Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, et al. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science 2013,342:1484-1490.
    • (2013) Science , vol.342 , pp. 1484-1490
    • Lyumkis, D.1    Julien, J.P.2    de Val, N.3    Cupo, A.4    Potter, C.S.5    Klasse, P.J.6
  • 4
    • 55849141268 scopus 로고    scopus 로고
    • Viral sequence diversity: challenges for AIDS vaccine designs
    • McBurney SP, Ross TM. Viral sequence diversity: challenges for AIDS vaccine designs. Expert Rev Vaccines 2008,7:1405-1417.
    • (2008) Expert Rev Vaccines , vol.7 , pp. 1405-1417
    • McBurney, S.P.1    Ross, T.M.2
  • 7
    • 0037069682 scopus 로고    scopus 로고
    • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
    • Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, et al. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature 2002,420:678-682.
    • (2002) Nature , vol.420 , pp. 678-682
    • Kwong, P.D.1    Doyle, M.L.2    Casper, D.J.3    Cicala, C.4    Leavitt, S.A.5    Majeed, S.6
  • 9
    • 36148991560 scopus 로고    scopus 로고
    • Extensive maturation of cross-reactive HIV-1 neutralizing antibodies but not of neutralizing antibodies against the SARS CoV, Nipah and Hendra viruses
    • Seattle, Washington, USA
    • Chen W, Zhu Z, Zhang M, Prabakaran P, Feng Y, Quinnan GV, et al. Extensive maturation of cross-reactive HIV-1 neutralizing antibodies but not of neutralizing antibodies against the SARS CoV, Nipah and Hendra viruses. In: AIDS Vaccine. Seattle, Washington, USA; 2007. pp. P10-18.
    • (2007) AIDS Vaccine
    • Chen, W.1    Zhu, Z.2    Zhang, M.3    Prabakaran, P.4    Feng, Y.5    Quinnan, G.V.6
  • 10
    • 65949114941 scopus 로고    scopus 로고
    • All known cross reactive HIV-1 neutralizing antibodies are highly divergent from germline and their elicitation may require prolonged periods of time
    • Chen W, Zhu Z, Zhang MY, Macagno A, Prabakaran P, Owens J, et al. All known cross reactive HIV-1 neutralizing antibodies are highly divergent from germline and their elicitation may require prolonged periods of time. AIDS Res Hum Retroviruses 2008,24:11-12.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 11-12
    • Chen, W.1    Zhu, Z.2    Zhang, M.Y.3    Macagno, A.4    Prabakaran, P.5    Owens, J.6
  • 11
    • 70449701456 scopus 로고    scopus 로고
    • Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens
    • Xiao X, Chen W, Feng Y, Zhu Z, Prabakaran P, Wang Y, et al. Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens. Biochem Biophys Res Commun 2009,390:404-409.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 404-409
    • Xiao, X.1    Chen, W.2    Feng, Y.3    Zhu, Z.4    Prabakaran, P.5    Wang, Y.6
  • 12
    • 77953655567 scopus 로고    scopus 로고
    • Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies
    • Xiao X, Chen W, Feng Y, Dimitrov DS. Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies. Viruses 2009,1:802-817.
    • (2009) Viruses , vol.1 , pp. 802-817
    • Xiao, X.1    Chen, W.2    Feng, Y.3    Dimitrov, D.S.4
  • 13
    • 77953673590 scopus 로고    scopus 로고
    • Therapeutic antibodies, vaccines and antibodyomes
    • Dimitrov DS. Therapeutic antibodies, vaccines and antibodyomes. MAbs 2010,2:347-356.
    • (2010) MAbs , vol.2 , pp. 347-356
    • Dimitrov, D.S.1
  • 14
    • 84870722258 scopus 로고    scopus 로고
    • Origin, diversity, and maturation of human antiviral antibodies analyzed by highthroughput sequencing
    • Prabakaran P, Zhu Z, Chen W, Gong R, Feng Y, Streaker E, et al. Origin, diversity, and maturation of human antiviral antibodies analyzed by highthroughput sequencing. Front Microbiol 2012,3:277.
    • (2012) Front Microbiol , vol.3 , pp. 277
    • Prabakaran, P.1    Zhu, Z.2    Chen, W.3    Gong, R.4    Feng, Y.5    Streaker, E.6
  • 15
    • 84879302728 scopus 로고    scopus 로고
    • HIV-1 neutralizing antibodies: understanding nature's pathways
    • Mascola JR, Haynes BF. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev 2013,254:225-244.
    • (2013) Immunol Rev , vol.254 , pp. 225-244
    • Mascola, J.R.1    Haynes, B.F.2
  • 16
    • 84898876770 scopus 로고    scopus 로고
    • Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013
    • Van Regenmortel MH, Andrieu JM, Dimitrov DS, Ensoli B, Hioe CE, Moog C, et al. Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013. J AIDS Clin Res 2014,5:1-5.
    • (2014) J AIDS Clin Res , vol.5 , pp. 1-5
    • Van Regenmortel, M.H.1    Andrieu, J.M.2    Dimitrov, D.S.3    Ensoli, B.4    Hioe, C.E.5    Moog, C.6
  • 17
    • 64949105877 scopus 로고    scopus 로고
    • Construction of a large naive human phage-displayed Fab library through one-step cloning
    • Zhu Z, Dimitrov DS. Construction of a large naive human phage-displayed Fab library through one-step cloning. Methods Mol Biol 2009,525:129-142.
    • (2009) Methods Mol Biol , vol.525 , pp. 129-142
    • Zhu, Z.1    Dimitrov, D.S.2
  • 18
    • 84862269218 scopus 로고    scopus 로고
    • Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations
    • Prabakaran P, Chen W, Singarayan MG, Stewart CC, Streaker E, Feng Y, et al. Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations. Immunogenetics 2012,64:337-350.
    • (2012) Immunogenetics , vol.64 , pp. 337-350
    • Prabakaran, P.1    Chen, W.2    Singarayan, M.G.3    Stewart, C.C.4    Streaker, E.5    Feng, Y.6
  • 19
    • 84867350002 scopus 로고    scopus 로고
    • IMGT((R)) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS
    • Alamyar E, Duroux P, Lefranc MP, Giudicelli V. IMGT((R)) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS. Methods Mol Biol 2012,882:569-604.
    • (2012) Methods Mol Biol , vol.882 , pp. 569-604
    • Alamyar, E.1    Duroux, P.2    Lefranc, M.P.3    Giudicelli, V.4
  • 20
    • 0002051540 scopus 로고    scopus 로고
    • BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT
    • Hall TA. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl. Acids. Symp. Ser. 1999,41:95-98.
    • (1999) Nucl. Acids. Symp. Ser. , vol.41 , pp. 95-98
    • Hall, T.A.1
  • 21
    • 71749099862 scopus 로고    scopus 로고
    • phyloXML: XML for evolutionary biology and comparative genomics
    • Han MV, Zmasek CM. phyloXML: XML for evolutionary biology and comparative genomics. BMC Bioinformatics 2009,10:356.
    • (2009) BMC Bioinformatics , vol.10 , pp. 356
    • Han, M.V.1    Zmasek, C.M.2
  • 22
    • 80052942203 scopus 로고    scopus 로고
    • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
    • Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C, et al. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science 2011,333:1593-1602.
    • (2011) Science , vol.333 , pp. 1593-1602
    • Wu, X.1    Zhou, T.2    Zhu, J.3    Zhang, B.4    Georgiev, I.5    Wang, C.6
  • 23
    • 80052925616 scopus 로고    scopus 로고
    • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
    • Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TY, et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 2011,333:1633-1637.
    • (2011) Science , vol.333 , pp. 1633-1637
    • Scheid, J.F.1    Mouquet, H.2    Ueberheide, B.3    Diskin, R.4    Klein, F.5    Oliveira, T.Y.6
  • 24
    • 84905672117 scopus 로고    scopus 로고
    • Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1
    • Yu L, Guan Y. Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1. Front Immunol 2014,5:250.
    • (2014) Front Immunol , vol.5 , pp. 250
    • Yu, L.1    Guan, Y.2
  • 25
  • 26
    • 84878626061 scopus 로고    scopus 로고
    • Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
    • McGuire AT, Hoot S, Dreyer AM, Lippy A, Stuart A, Cohen KW, et al. Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies. J Exp Med 2013,210:655-663.
    • (2013) J Exp Med , vol.210 , pp. 655-663
    • McGuire, A.T.1    Hoot, S.2    Dreyer, A.M.3    Lippy, A.4    Stuart, A.5    Cohen, K.W.6
  • 27
    • 84896690177 scopus 로고    scopus 로고
    • Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D
    • McGuire AT, Glenn JA, Lippy A, Stamatatos L. Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D. J Virol 2014,88:2645-2657.
    • (2014) J Virol , vol.88 , pp. 2645-2657
    • McGuire, A.T.1    Glenn, J.A.2    Lippy, A.3    Stamatatos, L.4
  • 28
    • 84876797103 scopus 로고    scopus 로고
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
    • Liao HX, Lynch R, Zhou T, Gao F, Alam SM, Boyd SD, et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 2013,496:469-476.
    • (2013) Nature , vol.496 , pp. 469-476
    • Liao, H.X.1    Lynch, R.2    Zhou, T.3    Gao, F.4    Alam, S.M.5    Boyd, S.D.6
  • 30
    • 84877609579 scopus 로고    scopus 로고
    • Rational HIV immunogen design to target specific germline B cell receptors
    • Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, et al. Rational HIV immunogen design to target specific germline B cell receptors. Science 2013,340:711-716.
    • (2013) Science , vol.340 , pp. 711-716
    • Jardine, J.1    Julien, J.P.2    Menis, S.3    Ota, T.4    Kalyuzhniy, O.5    McGuire, A.6
  • 31
    • 84875759341 scopus 로고    scopus 로고
    • Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
    • Klein F, Diskin R, Scheid JF, Gaebler C, Mouquet H, Georgiev IS, et al. Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell 2013,153:126-138.
    • (2013) Cell , vol.153 , pp. 126-138
    • Klein, F.1    Diskin, R.2    Scheid, J.F.3    Gaebler, C.4    Mouquet, H.5    Georgiev, I.S.6
  • 32
    • 84882589754 scopus 로고    scopus 로고
    • Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies
    • Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P, et al. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity 2013,39:245-258.
    • (2013) Immunity , vol.39 , pp. 245-258
    • Zhou, T.1    Zhu, J.2    Wu, X.3    Moquin, S.4    Zhang, B.5    Acharya, P.6
  • 33
    • 84876272159 scopus 로고    scopus 로고
    • Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains
    • Zhu J, Ofek G, Yang Y, Zhang B, Louder MK, Lu G, et al. Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. Proc Natl Acad Sci U S A 2013,110:6470-6475.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6470-6475
    • Zhu, J.1    Ofek, G.2    Yang, Y.3    Zhang, B.4    Louder, M.K.5    Lu, G.6
  • 34
    • 84886430146 scopus 로고    scopus 로고
    • De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts
    • Zhu J, Wu X, Zhang B, McKee K, O'Dell S, Soto C, et al. De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts. Proc Natl Acad Sci U S A 2013,110:E4088-4097.
    • (2013) Proc Natl Acad Sci U S A , vol.110
    • Zhu, J.1    Wu, X.2    Zhang, B.3    McKee, K.4    O'Dell, S.5    Soto, C.6
  • 35
    • 84888251984 scopus 로고    scopus 로고
    • The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
    • Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog 2013,9:e1003754.
    • (2013) PLoS Pathog , vol.9
    • Sok, D.1    Laserson, U.2    Laserson, J.3    Liu, Y.4    Vigneault, F.5    Julien, J.P.6
  • 36
    • 80055115557 scopus 로고    scopus 로고
    • Cross-reactive HIV- 1-neutralizing human monoclonal antibodies identified from a patient with 2F5- like antibodies
    • Zhu Z, Qin HR, Chen W, Zhao Q, Shen X, Schutte R, et al. Cross-reactive HIV- 1-neutralizing human monoclonal antibodies identified from a patient with 2F5- like antibodies. J Virol 2011,85:11401-11408.
    • (2011) J Virol , vol.85 , pp. 11401-11408
    • Zhu, Z.1    Qin, H.R.2    Chen, W.3    Zhao, Q.4    Shen, X.5    Schutte, R.6
  • 37
    • 84896737636 scopus 로고    scopus 로고
    • Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6
    • Ofek G, Zirkle B, Yang Y, Zhu Z, McKee K, Zhang B, et al. Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6. J Virol 2014,88:2426-2441.
    • (2014) J Virol , vol.88 , pp. 2426-2441
    • Ofek, G.1    Zirkle, B.2    Yang, Y.3    Zhu, Z.4    McKee, K.5    Zhang, B.6
  • 38
    • 84902131373 scopus 로고    scopus 로고
    • Early development of broadly neutralizing antibodies in HIV-1-infected infants
    • Goo L, Chohan V, Nduati R, Overbaugh J. Early development of broadly neutralizing antibodies in HIV-1-infected infants. Nat Med 2014,20:655-658.
    • (2014) Nat Med , vol.20 , pp. 655-658
    • Goo, L.1    Chohan, V.2    Nduati, R.3    Overbaugh, J.4
  • 39
    • 73949116413 scopus 로고    scopus 로고
    • Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
    • Glanville J, Zhai W, Berka J, Telman D, Huerta G, Mehta GR, et al. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proc Natl Acad Sci U S A 2009,106:20216-20221.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20216-20221
    • Glanville, J.1    Zhai, W.2    Berka, J.3    Telman, D.4    Huerta, G.5    Mehta, G.R.6
  • 41
    • 84864363185 scopus 로고    scopus 로고
    • Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120
    • West AP, Jr., Diskin R, Nussenzweig MC, Bjorkman PJ. Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120. Proc Natl Acad Sci U S A 2012,109:E2083-2090.
    • (2012) Proc Natl Acad Sci U S A , vol.109
    • West, A.P.1    Jr Diskin, R.2    Nussenzweig, M.C.3    Bjorkman, P.J.4
  • 42
    • 33745053586 scopus 로고    scopus 로고
    • Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
    • Ippolito GC, Schelonka RL, Zemlin M, Ivanov, II, Kobayashi R, Zemlin C, et al. Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J Exp Med 2006,203:1567- 1578.
    • (2006) J Exp Med , vol.203
    • Ippolito, G.C.1    Schelonka, R.L.2    Zemlin, M.3    Ivanov, I.I.4    Kobayashi, R.5    Zemlin, C.6
  • 43
    • 58849120982 scopus 로고    scopus 로고
    • Preferential use of DH reading frame 2 alters B cell development and antigenspecific antibody production
    • Schelonka RL, Zemlin M, Kobayashi R, Ippolito GC, Zhuang Y, Gartland GL, et al. Preferential use of DH reading frame 2 alters B cell development and antigenspecific antibody production. J Immunol 2008,181:8409-8415.
    • (2008) J Immunol , vol.181 , pp. 8409-8415
    • Schelonka, R.L.1    Zemlin, M.2    Kobayashi, R.3    Ippolito, G.C.4    Zhuang, Y.5    Gartland, G.L.6
  • 44
    • 0025758239 scopus 로고
    • B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames
    • Gu H, Kitamura D, Rajewsky K. B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames. Cell 1991,65:47-54.
    • (1991) Cell , vol.65 , pp. 47-54
    • Gu, H.1    Kitamura, D.2    Rajewsky, K.3
  • 45
    • 84878073543 scopus 로고    scopus 로고
    • The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content
    • Benichou J, Glanville J, Prak ET, Azran R, Kuo TC, Pons J, et al. The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content. J Immunol 2013,190:5567-5577.
    • (2013) J Immunol , vol.190 , pp. 5567-5577
    • Benichou, J.1    Glanville, J.2    Prak, E.T.3    Azran, R.4    Kuo, T.C.5    Pons, J.6
  • 46
    • 58849143882 scopus 로고    scopus 로고
    • Regulation of repertoire development through genetic control of DH reading frame preference
    • Zemlin M, Schelonka RL, Ippolito GC, Zemlin C, Zhuang Y, Gartland GL, et al. Regulation of repertoire development through genetic control of DH reading frame preference. J Immunol 2008,181:8416-8424.
    • (2008) J Immunol , vol.181 , pp. 8416-8424
    • Zemlin, M.1    Schelonka, R.L.2    Ippolito, G.C.3    Zemlin, C.4    Zhuang, Y.5    Gartland, G.L.6
  • 48
    • 84860759632 scopus 로고    scopus 로고
    • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
    • Haynes BF, Kelsoe G, Harrison SC, Kepler TB. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol 2012,30:423- 433.
    • (2012) Nat Biotechnol , vol.30 , pp. 423-433
    • Haynes, B.F.1    Kelsoe, G.2    Harrison, S.C.3    Kepler, T.B.4
  • 50
    • 84887315888 scopus 로고    scopus 로고
    • Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors
    • Alam SM, Dennison SM, Aussedat B, Vohra Y, Park PK, Fernandez-Tejada A, et al. Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proc Natl Acad Sci U S A 2013,110:18214-18219.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 18214-18219
    • Alam, S.M.1    Dennison, S.M.2    Aussedat, B.3    Vohra, Y.4    Park, P.K.5    Fernandez-Tejada, A.6
  • 51
    • 84940335959 scopus 로고    scopus 로고
    • Identification of non-HIV immunogens that bind to germline b12 predecessors and elicit cross-reactive neutralizing HIV-1 antibodies
    • Yang Z, Li J, Liu Q, Yuan T, Zhang Y, Chen LQ, et al. Identification of non-HIV immunogens that bind to germline b12 predecessors and elicit cross-reactive neutralizing HIV-1 antibodies AIDS 2014.
    • (2014) AIDS
    • Yang, Z.1    Li, J.2    Liu, Q.3    Yuan, T.4    Zhang, Y.5    Chen, L.Q.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.