The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content

Journal of Immunology

Volumn 190, Issue 11, 2013, Pages 5567-5577

  Benichou, Jennifer ^a   Glanville, Jacob ^b   Luning Prak, Eline T ^c   Azran, Roy ^a   Kuo, Tracy C ^b   Pons, Jaume ^b   Desmarais, Cindy ^d   Tsaban, Lea ^a   Louzoun, Yoram ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b PFIZER INC   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d ADAPTIVE BIOTECHNOLOGIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DH GENE; FEMALE; GENE; GENETIC VARIABILITY; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYDROPHOBICITY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; MALE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENETIC TREE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; VDJ EXON; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; B LYMPHOCYTE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; GENE EXPRESSION; GENE REARRANGEMENT; GENETICS; IMMUNOGLOBULIN STRUCTURE; IMMUNOGLOBULIN VARIABLE REGION; METABOLISM; MIDDLE AGED; REPRODUCIBILITY; STOP CODON; VDJ RECOMBINATION;

ADULT; AMINO ACID SEQUENCE; ANTIBODY DIVERSITY; B-LYMPHOCYTE SUBSETS; BASE SEQUENCE; CODON, TERMINATOR; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; GENE EXPRESSION; GENE REARRANGEMENT; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; MALE; MIDDLE AGED; READING FRAMES; REPRODUCIBILITY OF RESULTS; V(D)J RECOMBINATION; YOUNG ADULT;

MLCS; MLOWN;

EID: 84878073543     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201929     Document Type: Article

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