Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

PLoS Pathogens

Volumn 9, Issue 1, 2013, Pages

  Hoot, Sam ^a,h   McGuire, Andrew T ^a   Cohen, Kristen W ^a,b   Strong, Roland K ^c   Hangartner, Lars ^d   Klein, Florian ^e   Diskin, Ron ^f,i   Scheid, Johannes F ^e   Sather, D Noah ^a   Burton, Dennis R ^d,g   Stamatatos, Leonidas ^a,b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

^f CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h Altravax Inc   (United States)

ⁱ WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIBODY; EPITOPE; GLYCINE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 140; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE ACTIVATION; BURKITT LYMPHOMA; CALCIUM MOBILIZATION; CELL MATURATION; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INTERFEROMETRY; INTRACELLULAR SIGNALING; NONHUMAN; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SOMATIC MUTATION; TRANSIENT TRANSFECTION;

AIDS VACCINES; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; ANTIGENS, CD4; ANTIGENS, VIRAL; B-LYMPHOCYTES; CELL LINE; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES; HEK293 CELLS; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; LYMPHOCYTE ACTIVATION; NEUTRALIZATION TESTS;

EID: 84875061923     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003106     Document Type: Article

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