-
1
-
-
33747830026
-
Artificial transmutation of the gene
-
Muller H.J. Artificial transmutation of the gene. Science 1927, 66:84-87.
-
(1927)
Science
, vol.66
, pp. 84-87
-
-
Muller, H.J.1
-
2
-
-
84907481031
-
C. elegans whole genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
-
Meier B., Cooke S.L., Weiss J., Bailly A.P., Alexandrov L.B., et al. C. elegans whole genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Genome Res. 2014, 16:2014. 10.1101/gr.175547.114.
-
(2014)
Genome Res.
, vol.16
, pp. 2014
-
-
Meier, B.1
Cooke, S.L.2
Weiss, J.3
Bailly, A.P.4
Alexandrov, L.B.5
-
3
-
-
84893502065
-
Mutational landscape of yeast mutator strains
-
Serero A., Jubin C., Loeillet S., Legoix-Ne P., Nicolas A.G. Mutational landscape of yeast mutator strains. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:1897-1902.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 1897-1902
-
-
Serero, A.1
Jubin, C.2
Loeillet, S.3
Legoix-Ne, P.4
Nicolas, A.G.5
-
4
-
-
84865208871
-
Rate of de novo mutations and the importance of father's age to disease risk
-
Kong A., Frigge M.L., Masson G., Besenbacher S., Sulem P., et al. Rate of de novo mutations and the importance of father's age to disease risk. Nature 2012, 488:471-475.
-
(2012)
Nature
, vol.488
, pp. 471-475
-
-
Kong, A.1
Frigge, M.L.2
Masson, G.3
Besenbacher, S.4
Sulem, P.5
-
5
-
-
0029078029
-
Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human
-
Drost J.B., Lee W.R. Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. Environ. Mol. Mutagen. 1995, 25(Suppl 26):S48-S64.
-
(1995)
Environ. Mol. Mutagen.
, vol.25
, pp. S48-S64
-
-
Drost, J.B.1
Lee, W.R.2
-
6
-
-
72949119310
-
Complex landscapes of somatic rearrangement in human breast cancer genomes
-
Stephens P.J., McBride D.J., Lin M.L., Varela I., Pleasance E.D., et al. Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 2009, 462:1005-1010.
-
(2009)
Nature
, vol.462
, pp. 1005-1010
-
-
Stephens, P.J.1
McBride, D.J.2
Lin, M.L.3
Varela, I.4
Pleasance, E.D.5
-
7
-
-
78049380554
-
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
-
Campbell P.J., Yachida S., Mudie L.J., Stephens P.J., Pleasance E.D., et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 2010, 467:1109-1113.
-
(2010)
Nature
, vol.467
, pp. 1109-1113
-
-
Campbell, P.J.1
Yachida, S.2
Mudie, L.J.3
Stephens, P.J.4
Pleasance, E.D.5
-
8
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., et al. Patterns of somatic mutation in human cancer genomes. Nature 2007, 446:153-158.
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
-
9
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov L.B., Nik-Zainal S., Wedge D.C., Aparicio S.A., Behjati S., et al. Signatures of mutational processes in human cancer. Nature 2013, 500:415-421.
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.4
Behjati, S.5
-
10
-
-
78650959663
-
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
-
Stephens P.J., Greenman C.D., Fu B., Yang F., Bignell G.R., et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 2011, 144:27-40.
-
(2011)
Cell
, vol.144
, pp. 27-40
-
-
Stephens, P.J.1
Greenman, C.D.2
Fu, B.3
Yang, F.4
Bignell, G.R.5
-
11
-
-
80052916562
-
Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements
-
Liu P., Erez A., Nagamani S.C., Dhar S.U., Kolodziejska K.E., et al. Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell 2011, 146:889-903.
-
(2011)
Cell
, vol.146
, pp. 889-903
-
-
Liu, P.1
Erez, A.2
Nagamani, S.C.3
Dhar, S.U.4
Kolodziejska, K.E.5
-
12
-
-
37349109667
-
A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders
-
Lee J.A., Carvalho C.M., Lupski J.R. A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell 2007, 131:1235-1247.
-
(2007)
Cell
, vol.131
, pp. 1235-1247
-
-
Lee, J.A.1
Carvalho, C.M.2
Lupski, J.R.3
-
13
-
-
0019061841
-
Unc-93(e1500): a behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype
-
Greenwald I.S., Horvitz H.R. unc-93(e1500): a behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype. Genetics 1980, 96:147-164.
-
(1980)
Genetics
, vol.96
, pp. 147-164
-
-
Greenwald, I.S.1
Horvitz, H.R.2
-
14
-
-
77955499817
-
Whole-genome profiling of mutagenesis in Caenorhabditis elegans
-
Flibotte S., Edgley M.L., Chaudhry I., Taylor J., Neil S.E., et al. Whole-genome profiling of mutagenesis in Caenorhabditis elegans. Genetics 2010, 185:431-441.
-
(2010)
Genetics
, vol.185
, pp. 431-441
-
-
Flibotte, S.1
Edgley, M.L.2
Chaudhry, I.3
Taylor, J.4
Neil, S.E.5
-
15
-
-
0035934438
-
Optimization of ENU mutagenesis of Caenorhabditis elegans
-
De Stasio E.A., Dorman S. Optimization of ENU mutagenesis of Caenorhabditis elegans. Mutat. Res. 2001, 495:81-88.
-
(2001)
Mutat. Res.
, vol.495
, pp. 81-88
-
-
De Stasio, E.A.1
Dorman, S.2
-
16
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
-
Petitjean A., Mathe E., Kato S., Ishioka C., Tavtigian S.V., et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum. Mutat. 2007, 28:622-629.
-
(2007)
Hum. Mutat.
, vol.28
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
Ishioka, C.4
Tavtigian, S.V.5
-
17
-
-
20444362414
-
Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans
-
Denver D.R., Feinberg S., Estes S., Thomas W.K., Lynch M. Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Genetics 2005, 170:107-113.
-
(2005)
Genetics
, vol.170
, pp. 107-113
-
-
Denver, D.R.1
Feinberg, S.2
Estes, S.3
Thomas, W.K.4
Lynch, M.5
-
18
-
-
33748894494
-
The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation
-
Denver D.R., Feinberg S., Steding C., Durbin M., Lynch M. The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation. Genetics 2006, 174:57-65.
-
(2006)
Genetics
, vol.174
, pp. 57-65
-
-
Denver, D.R.1
Feinberg, S.2
Steding, C.3
Durbin, M.4
Lynch, M.5
-
19
-
-
84901823399
-
Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans
-
Roerink S.F., van Schendel R., Tijsterman M. Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans. Genome Res. 2014, 24:954-962.
-
(2014)
Genome Res.
, vol.24
, pp. 954-962
-
-
Roerink, S.F.1
van Schendel, R.2
Tijsterman, M.3
-
20
-
-
0031419674
-
Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects
-
Glaab W.E., Tindall K.R. Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects. Carcinogenesis 1997, 18:1-8.
-
(1997)
Carcinogenesis
, vol.18
, pp. 1-8
-
-
Glaab, W.E.1
Tindall, K.R.2
-
21
-
-
0029101616
-
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
-
de Wind N., Dekker M., Berns A., Radman M., te Riele H. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 1995, 82:321-330.
-
(1995)
Cell
, vol.82
, pp. 321-330
-
-
de Wind, N.1
Dekker, M.2
Berns, A.3
Radman, M.4
te Riele, H.5
-
22
-
-
0036699095
-
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA
-
Cheung I., Schertzer M., Rose A., Lansdorp P.M. Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat. Genet. 2002, 31:405-409.
-
(2002)
Nat. Genet.
, vol.31
, pp. 405-409
-
-
Cheung, I.1
Schertzer, M.2
Rose, A.3
Lansdorp, P.M.4
-
23
-
-
84893870945
-
A polymerase theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites
-
Koole W., van Schendel R., Karambelas A.E., van Heteren J.T., Okihara K.L., et al. A polymerase theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites. Nat. Commun. 2014, 5:3216.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3216
-
-
Koole, W.1
van Schendel, R.2
Karambelas, A.E.3
van Heteren, J.T.4
Okihara, K.L.5
-
24
-
-
44949114282
-
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability
-
Wu Y., Shin-ya K., Brosh R.M. FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol. Cell. Biol. 2008, 28:4116-4128.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4116-4128
-
-
Wu, Y.1
Shin-ya, K.2
Brosh, R.M.3
-
25
-
-
61349135721
-
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts
-
London T.B., Barber L.J., Mosedale G., Kelly G.P., Balasubramanian S., et al. FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J. Biol. Chem. 2008, 283:36132-36139.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 36132-36139
-
-
London, T.B.1
Barber, L.J.2
Mosedale, G.3
Kelly, G.P.4
Balasubramanian, S.5
-
26
-
-
33745407668
-
Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans
-
Youds J.L., O'Neil N.J., Rose A.M. Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Genetics 2006, 173:697-708.
-
(2006)
Genetics
, vol.173
, pp. 697-708
-
-
Youds, J.L.1
O'Neil, N.J.2
Rose, A.M.3
-
27
-
-
0037356808
-
Phenotype-based identification of mouse chromosome instability mutants
-
Shima N., Hartford S.A., Duffy T., Wilson L.A., Schimenti K.J., et al. Phenotype-based identification of mouse chromosome instability mutants. Genetics 2003, 163:1031-1040.
-
(2003)
Genetics
, vol.163
, pp. 1031-1040
-
-
Shima, N.1
Hartford, S.A.2
Duffy, T.3
Wilson, L.A.4
Schimenti, K.J.5
-
28
-
-
8644233355
-
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm
-
Shima N., Munroe R.J., Schimenti J.C. The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Mol. Cell. Biol. 2004, 24:10381-10389.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10381-10389
-
-
Shima, N.1
Munroe, R.J.2
Schimenti, J.C.3
-
29
-
-
77950842499
-
A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown
-
Higgins G.S., Prevo R., Lee Y.F., Helleday T., Muschel R.J., et al. A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. Cancer Res. 2010, 70:2984-2993.
-
(2010)
Cancer Res.
, vol.70
, pp. 2984-2993
-
-
Higgins, G.S.1
Prevo, R.2
Lee, Y.F.3
Helleday, T.4
Muschel, R.J.5
-
30
-
-
77955820979
-
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability
-
Lemee F., Bergoglio V., Fernandez-Vidal A., Machado-Silva A., Pillaire M.J., et al. DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:13390-13395.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 13390-13395
-
-
Lemee, F.1
Bergoglio, V.2
Fernandez-Vidal, A.3
Machado-Silva, A.4
Pillaire, M.J.5
-
31
-
-
79251525596
-
Overexpression of POLQ confers a poor prognosis in early breast cancer patients
-
Higgins G.S., Harris A.L., Prevo R., Helleday T., McKenna W.G., et al. Overexpression of POLQ confers a poor prognosis in early breast cancer patients. Oncotarget 2010, 1:175-184.
-
(2010)
Oncotarget
, vol.1
, pp. 175-184
-
-
Higgins, G.S.1
Harris, A.L.2
Prevo, R.3
Helleday, T.4
McKenna, W.G.5
-
32
-
-
0034642513
-
MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
-
Ahmed S., Hodgkin J. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Nature 2000, 403:159-164.
-
(2000)
Nature
, vol.403
, pp. 159-164
-
-
Ahmed, S.1
Hodgkin, J.2
-
33
-
-
79955426856
-
DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions
-
Lowden M.R., Flibotte S., Moerman D.G., Ahmed S. DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions. Science 2011, 332:468-471.
-
(2011)
Science
, vol.332
, pp. 468-471
-
-
Lowden, M.R.1
Flibotte, S.2
Moerman, D.G.3
Ahmed, S.4
-
34
-
-
0000075523
-
The behavior in successive nuclear divisions of a chromosome broken at meiosis
-
McClintock B. The behavior in successive nuclear divisions of a chromosome broken at meiosis. Proc. Natl. Acad. Sci. U. S. A. 1939, 25:405-416.
-
(1939)
Proc. Natl. Acad. Sci. U. S. A.
, vol.25
, pp. 405-416
-
-
McClintock, B.1
-
35
-
-
0001294157
-
The stability of broken ends of chromosomes in Zea mays
-
McClintock B. The stability of broken ends of chromosomes in Zea mays. Genetics 1941, 26:234-282.
-
(1941)
Genetics
, vol.26
, pp. 234-282
-
-
McClintock, B.1
-
36
-
-
84897528140
-
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia
-
Li Y., Schwab C., Ryan S.L., Papaemmanuil E., Robinson H.M., et al. Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia. Nature 2014, 508:98-102.
-
(2014)
Nature
, vol.508
, pp. 98-102
-
-
Li, Y.1
Schwab, C.2
Ryan, S.L.3
Papaemmanuil, E.4
Robinson, H.M.5
-
37
-
-
84899991195
-
XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4
-
Klein Douwel D., Boonen R.A., Long D.T., Szypowska A.A., Raschle M., et al. XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. Mol. Cell 2014, 54:460-471.
-
(2014)
Mol. Cell
, vol.54
, pp. 460-471
-
-
Klein Douwel, D.1
Boonen, R.A.2
Long, D.T.3
Szypowska, A.A.4
Raschle, M.5
-
38
-
-
0034714401
-
Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease
-
Kuraoka I., Kobertz W.R., Ariza R.R., Biggerstaff M., Essigmann J.M., et al. Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease. J. Biol. Chem. 2000, 275:26632-26636.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26632-26636
-
-
Kuraoka, I.1
Kobertz, W.R.2
Ariza, R.R.3
Biggerstaff, M.4
Essigmann, J.M.5
-
39
-
-
0033781210
-
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells
-
De Silva I.U., McHugh P.J., Clingen P.H., Hartley J.A. Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells. Mol. Cell. Biol. 2000, 20:7980-7990.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 7980-7990
-
-
De Silva, I.U.1
McHugh, P.J.2
Clingen, P.H.3
Hartley, J.A.4
-
40
-
-
77954310242
-
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
-
Adamo A., Collis S.J., Adelman C.A., Silva N., Horejsi Z., et al. Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol. Cell 2010, 39:25-35.
-
(2010)
Mol. Cell
, vol.39
, pp. 25-35
-
-
Adamo, A.1
Collis, S.J.2
Adelman, C.A.3
Silva, N.4
Horejsi, Z.5
-
41
-
-
77953879925
-
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway
-
Pace P., Mosedale G., Hodskinson M.R., Rosado I.V., Sivasubramaniam M., et al. Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science 2010, 329:219-223.
-
(2010)
Science
, vol.329
, pp. 219-223
-
-
Pace, P.1
Mosedale, G.2
Hodskinson, M.R.3
Rosado, I.V.4
Sivasubramaniam, M.5
|