DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions

Science

Volumn 332, Issue 6028, 2011, Pages 468-471

  Rochelle Lowden, Mia ^a   Flibotte, Stephane ^b   Moerman, Donald G ^b   Ahmed, Shawn ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME; DISEASE PREVALENCE; GENOME; MITOCHONDRIAL DNA; MUTATION;

ARTICLE; CAENORHABDITIS ELEGANS; CHROMOSOME 10; CHROMOSOME 2; CHROMOSOME 3; CHROMOSOME 4; CHROMOSOME 5; CONTROLLED STUDY; DNA SYNTHESIS; END TO END CHROMOSOME FUSION; GENE DUPLICATION; GENE REARRANGEMENT; GENE REPLICATION; GENETIC PARAMETERS; MUTANT; NONHUMAN; PRIORITY JOURNAL; TELOMERE;

ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CHROMATIDS; CHROMOSOME BREAKPOINTS; CHROMOSOME DUPLICATION; CHROMOSOMES; DNA REPLICATION; DNA, HELMINTH; INVERTED REPEAT SEQUENCES; MODELS, GENETIC; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; TELOMERASE; TELOMERE;

CAENORHABDITIS ELEGANS;

EID: 79955426856     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1199022     Document Type: Article

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29. We thank J. Maydan for technical assistance; D. Reiner, J. Sekelsky, L. Shtessel, D. Shippen, and T. Petes for comments on the manuscript; and D. Ramsden for discussion. S.A. and M.L. were supported by NIH grantsGM066228 and GM072150. D.G.M. was supported by funds from Genome Canada and Genome British Columbia and the Michael Smith Research Foundation. D.G.M. is a fellow of the Canadian Institute for Advanced Research.