Multitarget effects of quercetin in leukemia

Chest

Volumn 146, Issue 6, 2014, Pages 1240-1250

  Maso, Victor ^a   Calgarotto, Andrana Karla ^a   Franchi, Gilberto Carlos ^a   Nowill, Alexandre Eduardo ^a   Filho, Paulo Latuf ^b   Vassallo, José ^b   Saad, Sara Teresinha Olalla ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Laboratory of Investigative and Molecular Pathology   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; CASPASE 9; CHLOROQUINE; CYCLIN A; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLIN E; CYTOCHROME C; FAS LIGAND; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN P21; PROTEIN P27; QUERCETIN; RETINOBLASTOMA PROTEIN; ANTIOXIDANT; REACTIVE OXYGEN METABOLITE; TUMOR MARKER; CASPASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VIABILITY; CHRONIC MYELOMONOCYTIC LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; MALE; NONHUMAN; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; ENZYME IMMUNOASSAY; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONOBESE DIABETIC MOUSE; PATHOLOGY; TUMOR CELL CULTURE; WESTERN BLOTTING; ANTIOXIDANT ACTIVITY; CANCER INHIBITION; CANCER SIZE; CELL CYCLE; CYTOTOXICITY; LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED NOD; QUERCETIN; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919389870     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-13-0383     Document Type: Article

References (46)

1. Melo MB, Ahmad NN, Lima CSP, Pagnano KBB, Bordin S, Lorand-Metze I, et al. Mutations in the p53 gene in acute myeloid leukemia patients correlate with poor prognosis. Hematology 2002;7:13-9.
2. Mufti GJ. Pathobiology, classification, and diagnosis of myelodys-plastic syndrome. Best Pract Res Clin Haematol 2004;17:543-57.
3. Yanada M, Naoe T. Acute myeloid leukemia in older adults. Int J Hematol 2012;96:186-93.
4. Boots AW, Haenen GRMM, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585:325-37.
5. Avci CB, Yilmaz S, Dogan ZO, Saydam G, Dodurga Y, Ekiz HA, et al. Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology 2011;16:303-7.
6. Lee W-J, Chen Y-R, Tseng T-H. Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep 2011;25:583-91.
7. Aune D, Lau R, Chan DSM, Vieira R, Greenwood DC, Kampman E, et al. Nonlinear reduction in risk for colorectal cancer by fruit and vegetable intake based on meta-analysis of prospective studies. Gastroenterology 2011;141:106-18.
8. Khan R, Aggerholm A, Hokland P, Hassan M, Hellström-Lindberg E. A pharmacodynamic study of 5-azacytidine in the P39 cell line. Exp Hematol 2006;34:35-43.
9. Khan R, Schmidt-Mende J, Karimi M, Gogvadze V, Hassan M, Ekström TJ, et al. Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells. Exp Hematol 2008;36:149-57.
10. Braun T, Carvalho G, Coquelle A, Vozenin M-C, Lepelley P, Hirsch F, et al. NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome. Blood 2006;107:1156-65.
11. Schmidt-Mende J, Gogvadze V, Hellström-Lindberg E, Zhivotovsky B. Early mitochondrial alterations in ATRA-induced cell death. Cell Death Differ 2006;13:119-28.
12. Steensma DP. P39/Tsugane cells are a false cell line contaminated with HL-60 cells and are not suitable for mechanistic studies in myelodysplastic syndromes. Haematologica 2010;95:1229-30.
13. Drexler HG, Dirks WG, Macleod RAF. Many are called MDS cell lines: one is chosen. Leuk Res 2009;33:1011-6.
14. Nagai M, Seki S, Kitahara T, Abe T, Minato K, Watanabe S, et al. A novel human myelomonocytoid cell line, P39/Tsugane, derived from overt leukemia following myelodysplastic syndrome. Gann 1984;75: 1100-7.
15. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
16. Zhang X-Q, Huang X-F, Hu X-B, Zhan Y-H, An Q-X, Yang S-M, et al. Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. Asian J Androl 2010;12:697-708.
17. Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy 2011;7:966-78.
18. Wang Y, Fei M, Cheng C, Zhang D, Lu J, He S, et al. Jun activation domain-binding protein 1 negatively regulate p27 kip1 in non-Hodgkin's lymphomas. Cancer Biol Ther 2008;7:460-7.
19. Cai B, Li X, Wang Y, Liu Y, Yang F, Chen H, et al. Apoptosis of bone marrow mesenchymal stem cells caused by homocysteine via activating JNK signal. PLoS ONE 2013;8:e63561.
20. Kim EK, Choi E-J. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010;1802:396-405.
21. Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature 2010;466:68-76.
22. Yang Z, Klionsky DJ. An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 2009;335:1-32.
23. Jeong J-H, An JY, Kwon YT, Rhee JG, Lee YJ. Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem 2009;106:73-82.
24. Gao W, Xiao F, Wang X, Chen T. Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3. Apoptosis 2013; 18:1201-13.
25. Cao L-C, Honeyman TW, Cooney R, Kennington L, Scheid CR, Jonassen JA. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. Kidney Int 2004;66:1890-900.
26. Mates JM, Segura JA, Alonso FJ, Marquez J. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol 2008;82:273-99.
27. Robaszkiewicz A, Balcerczyk A, Bartosz G. Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biol Int 2007;31: 1245-50.
28. Niture SK, Jaiswal AK. Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J Biol Chem 2011;286:44542-56.
29. Giansanti V, Torriglia A, Scovassi AI. Conversation between apoptosis and autophagy: "Is it your turn or mine?". Apoptosis 2011;16:321-33.
30. Zhu J, Wang KZQ, Chu CT. After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy 2013;9:1663-76.
31. Chen Y-J, Huang W-P, Yang Y-C, Lin C-P, Chen S-H, Hsu M-L, et al. Platonin induces autophagy-associated cell death in human leukemia cells. Autophagy 2009;5:173-83.
32. Kim RH, Coates JM, Bowles TL, McNerney GP, Sutcliffe J, Jung JU, et al. Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res 2009; 69:700-8.
33. Kim Y-H, Lee YJ. TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation. J Cell Biochem 2007;100:998-1009.
34. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004;306:990-5.
35. Mu C, Jia P, Yan Z, Liu X, Li X, Liu H. Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Methods Find Exp Clin Pharmacol 2007;29: 179-83.
36. Mitrea DM, Yoon M-K, Ou L, Kriwacki RW. Disorder-function relationships for the cell cycle regulatory proteins p21 and p27. Biol Chem 2012;393:259-74.
37. Ying H, Xiao Z-XJ. Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle 2006;5:506-8.
38. Bradham C, McClay DR. p38 MAPK in development and cancer. Cell Cycle 2006;5:824-8.
39. Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003;2:339-45.
40. Neergheen VS, Bahorun T, Taylor EW, Jen L-S, Aruoma OI. Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Toxicology 2010;278: 229-41.
41. Shimizu M, Shirakami Y, Moriwaki H. Targeting receptor tyrosine kinases for chemoprevention by green tea catechin, EGCG. Int J Mol Sci 2008;9:1034-49.
42. Hilger RA, Scheulen ME, Strumberg D. The Ras-Raf-MEK-ERK pathway in the treatment of cancer. Onkologie 2002;25:511-8.
43. Kim G-Y, Mercer SE, Ewton DZ, Yan Z, Jin K, Friedman E. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem 2002;277:29792-802.
44. Gokbulut AA, Apohan E, Baran Y. Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest. Hematology 2013; 18:144-50.
45. Priyadarsini RV, Murugan RS, Sripriya P, Karunagaran D, Nagini S.The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells. Free Radic Res 2010;44:624-34.
46. Imbesi S, Musolino C, Allegra A, Saija A, Morabito F, Calapai G, et al. Oxidative stress in oncohematologic diseases: an update. Expert Rev Hematol 2013;6:317-25.