-
1
-
-
0036342388
-
Treatment of myelodysplastic syndromes with 5-azacytidine
-
Gryn J., Zeigler Z.R., Shadduck R.K., et al. Treatment of myelodysplastic syndromes with 5-azacytidine. Leuk Res 26 (2002) 893-897
-
(2002)
Leuk Res
, vol.26
, pp. 893-897
-
-
Gryn, J.1
Zeigler, Z.R.2
Shadduck, R.K.3
-
2
-
-
0027154222
-
Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes
-
Silverman L.R., Holland J.F., Weinberg R.S., et al. Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia 7 Suppl 1 (1993) 21-29
-
(1993)
Leukemia
, vol.7
, Issue.SUPPL. 1
, pp. 21-29
-
-
Silverman, L.R.1
Holland, J.F.2
Weinberg, R.S.3
-
3
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
-
Silverman L.R., Demakos E.P., Peterson B.L., et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 20 (2002) 2429-2440
-
(2002)
J Clin Oncol
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
-
4
-
-
0037092962
-
Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study
-
Kornblith A.B., Herndon II J.E., Silverman L.R., et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol 20 (2002) 2441-2452
-
(2002)
J Clin Oncol
, vol.20
, pp. 2441-2452
-
-
Kornblith, A.B.1
Herndon II, J.E.2
Silverman, L.R.3
-
5
-
-
0016838872
-
Kinetics and mechanisms of degradation of the antileukemic agent 5-azacytidine in aqueous solutions
-
Notari R.E., and DeYoung J.L. Kinetics and mechanisms of degradation of the antileukemic agent 5-azacytidine in aqueous solutions. J Pharm Sci 64 (1975) 1148-1157
-
(1975)
J Pharm Sci
, vol.64
, pp. 1148-1157
-
-
Notari, R.E.1
DeYoung, J.L.2
-
6
-
-
0022559050
-
Determination of the antileukemia agents cytarabine and azacitidine and their respective degradation products by high-performance liquid chromatography
-
Kissinger L.D., and Stemm N.L. Determination of the antileukemia agents cytarabine and azacitidine and their respective degradation products by high-performance liquid chromatography. J Chromatogr 353 (1986) 309-318
-
(1986)
J Chromatogr
, vol.353
, pp. 309-318
-
-
Kissinger, L.D.1
Stemm, N.L.2
-
7
-
-
0023242629
-
High-performance liquid chromatographic determination of 5-azacytidine in plasma
-
Rustum A.M., and Hoffman N.E. High-performance liquid chromatographic determination of 5-azacytidine in plasma. J Chromatogr 421 (1987) 387-391
-
(1987)
J Chromatogr
, vol.421
, pp. 387-391
-
-
Rustum, A.M.1
Hoffman, N.E.2
-
8
-
-
21244447049
-
Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies
-
Rudek M.A., Zhao M., He P., et al. Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies. J Clin Oncol 23 (2005) 3906-3911
-
(2005)
J Clin Oncol
, vol.23
, pp. 3906-3911
-
-
Rudek, M.A.1
Zhao, M.2
He, P.3
-
9
-
-
30344472703
-
A pharmacodynamic study of 5-azacytidine in the P39 cell line
-
Khan R., Aggerholm A., Hokland P., Hassan M., and Hellstrom-Lindberg E. A pharmacodynamic study of 5-azacytidine in the P39 cell line. Exp Hematol 34 (2006) 35-43
-
(2006)
Exp Hematol
, vol.34
, pp. 35-43
-
-
Khan, R.1
Aggerholm, A.2
Hokland, P.3
Hassan, M.4
Hellstrom-Lindberg, E.5
-
10
-
-
34247156577
-
Using LUMA: a luminometric based assay for global DNA-methylation
-
Karimi M., Johansson S., and Ekstrom T.J. Using LUMA: a luminometric based assay for global DNA-methylation. Epigenetics 1 (2006) 45-48
-
(2006)
Epigenetics
, vol.1
, pp. 45-48
-
-
Karimi, M.1
Johansson, S.2
Ekstrom, T.J.3
-
11
-
-
33744938449
-
LUMA (LUminometric Methylation Assay)-a high throughput method to the analysis of genomic DNA methylation
-
Karimi M., Johansson S., Stach D., et al. LUMA (LUminometric Methylation Assay)-a high throughput method to the analysis of genomic DNA methylation. Exp Cell Res 312 (2006) 1989-1995
-
(2006)
Exp Cell Res
, vol.312
, pp. 1989-1995
-
-
Karimi, M.1
Johansson, S.2
Stach, D.3
-
12
-
-
34247156577
-
Using LUMA: a luminometric based assay for global DNA-methylation
-
Karimi M., Johansson S., and Ekström T. Using LUMA: a luminometric based assay for global DNA-methylation. Epigenetics 1 (2006) 45-48
-
(2006)
Epigenetics
, vol.1
, pp. 45-48
-
-
Karimi, M.1
Johansson, S.2
Ekström, T.3
-
13
-
-
34247145010
-
Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease?
-
Stenvinkel P., Karimi M., Johansson S., et al. Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease?. J Intern Med 261 (2007) 488-499
-
(2007)
J Intern Med
, vol.261
, pp. 488-499
-
-
Stenvinkel, P.1
Karimi, M.2
Johansson, S.3
-
14
-
-
10644249986
-
Anticancer drug development based on modulation of the Bcl-2 family core apoptosis mechanism
-
Gardner C.R. Anticancer drug development based on modulation of the Bcl-2 family core apoptosis mechanism. Expert Rev Anticancer Ther 4 (2004) 1157-1177
-
(2004)
Expert Rev Anticancer Ther
, vol.4
, pp. 1157-1177
-
-
Gardner, C.R.1
-
15
-
-
3242778557
-
Differentiation-induced HL-60 cell apoptosis: a mechanism independent of mitochondrial disruption?
-
Doyle B.T., O'Neill A.J., Fitzpatrick J.M., and Watson R.W. Differentiation-induced HL-60 cell apoptosis: a mechanism independent of mitochondrial disruption?. Apoptosis 9 (2004) 345-352
-
(2004)
Apoptosis
, vol.9
, pp. 345-352
-
-
Doyle, B.T.1
O'Neill, A.J.2
Fitzpatrick, J.M.3
Watson, R.W.4
-
16
-
-
0032575752
-
Mitochondria and apoptosis
-
Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
-
(1998)
Science
, vol.281
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
18
-
-
0032999788
-
Poly (ADP-ribose) polymerase, nitric oxide and cell death
-
Pieper A.A., Verma A., Zhang J., and Snyder S.H. Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol Sci 20 (1999) 171-181
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 171-181
-
-
Pieper, A.A.1
Verma, A.2
Zhang, J.3
Snyder, S.H.4
-
19
-
-
10044224443
-
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death
-
Wang H., Yu S.W., Koh D.W., et al. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci 24 (2004) 10963-10973
-
(2004)
J Neurosci
, vol.24
, pp. 10963-10973
-
-
Wang, H.1
Yu, S.W.2
Koh, D.W.3
-
20
-
-
17144434775
-
Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke
-
Komjati K., Mabley J.G., Virag L., Southan G.J., Salzman A.L., and Szabo C. Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. Int J Mol Med 13 (2004) 373-382
-
(2004)
Int J Mol Med
, vol.13
, pp. 373-382
-
-
Komjati, K.1
Mabley, J.G.2
Virag, L.3
Southan, G.J.4
Salzman, A.L.5
Szabo, C.6
-
21
-
-
0348109491
-
Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity
-
Yu S.W., Wang H., Dawson T.M., and Dawson V.L. Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. Neurobiol Dis 14 (2003) 303-317
-
(2003)
Neurobiol Dis
, vol.14
, pp. 303-317
-
-
Yu, S.W.1
Wang, H.2
Dawson, T.M.3
Dawson, V.L.4
-
22
-
-
1242293646
-
Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution
-
Ahmad K.A., Clement M.V., Hanif I.M., and Pervaiz S. Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution. Cancer Res 64 (2004) 1452-1459
-
(2004)
Cancer Res
, vol.64
, pp. 1452-1459
-
-
Ahmad, K.A.1
Clement, M.V.2
Hanif, I.M.3
Pervaiz, S.4
-
23
-
-
0242524405
-
Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria
-
Clement M.V., Hirpara J.L., and Pervaiz S. Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria. Cell Death Differ 10 (2003) 1273-1285
-
(2003)
Cell Death Differ
, vol.10
, pp. 1273-1285
-
-
Clement, M.V.1
Hirpara, J.L.2
Pervaiz, S.3
-
24
-
-
0035959749
-
Activation of the RacGTPase inhibits apoptosis in human tumor cells
-
Pervaiz S., Cao J., Chao O.S., Chin Y.Y., and Clement M.V. Activation of the RacGTPase inhibits apoptosis in human tumor cells. Oncogene 20 (2001) 6263-6268
-
(2001)
Oncogene
, vol.20
, pp. 6263-6268
-
-
Pervaiz, S.1
Cao, J.2
Chao, O.S.3
Chin, Y.Y.4
Clement, M.V.5
-
26
-
-
0038079767
-
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
-
Rosato R.R., Almenara J.A., and Grant S. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Res 63 (2003) 3637-3645
-
(2003)
Cancer Res
, vol.63
, pp. 3637-3645
-
-
Rosato, R.R.1
Almenara, J.A.2
Grant, S.3
-
27
-
-
31544448567
-
NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome
-
Braun T., Carvalho G., Coquelle A., et al. NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome. Blood 107 (2006) 1156-1165
-
(2006)
Blood
, vol.107
, pp. 1156-1165
-
-
Braun, T.1
Carvalho, G.2
Coquelle, A.3
-
29
-
-
0034641918
-
The biochemistry of apoptosis
-
Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
30
-
-
0037119491
-
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis
-
Robertson J.D., Enoksson M., Suomela M., Zhivotovsky B., and Orrenius S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 277 (2002) 29803-29809
-
(2002)
J Biol Chem
, vol.277
, pp. 29803-29809
-
-
Robertson, J.D.1
Enoksson, M.2
Suomela, M.3
Zhivotovsky, B.4
Orrenius, S.5
-
31
-
-
0038449141
-
PARP-1, a determinant of cell survival in response to DNA damage
-
Bouchard V.J., Rouleau M., and Poirier G.G. PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31 (2003) 446-454
-
(2003)
Exp Hematol
, vol.31
, pp. 446-454
-
-
Bouchard, V.J.1
Rouleau, M.2
Poirier, G.G.3
-
32
-
-
0029013514
-
Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity
-
Murakami T., Li X., Gong J., Bhatia U., Traganos F., and Darzynkiewicz Z. Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity. Cancer Res 55 (1995) 3093-3098
-
(1995)
Cancer Res
, vol.55
, pp. 3093-3098
-
-
Murakami, T.1
Li, X.2
Gong, J.3
Bhatia, U.4
Traganos, F.5
Darzynkiewicz, Z.6
-
33
-
-
34250767283
-
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells
-
Kiziltepe T., Hideshima T., Catley L., et al. 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells. Mol Cancer Ther 6 (2007) 1718-1727
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1718-1727
-
-
Kiziltepe, T.1
Hideshima, T.2
Catley, L.3
-
34
-
-
38149090889
-
Mechanisms of DNA breaks induction in vivo by 5-azacytidine: paths of micronucleus induction by azaC
-
[Epub ahead of print]
-
Morales-Ramirez P., Vallarino-Kelly T., and Cruz-Vallejo V.L. Mechanisms of DNA breaks induction in vivo by 5-azacytidine: paths of micronucleus induction by azaC. J Appl Toxicol (2007 Aug 8) [Epub ahead of print]
-
(2007)
J Appl Toxicol
-
-
Morales-Ramirez, P.1
Vallarino-Kelly, T.2
Cruz-Vallejo, V.L.3
-
35
-
-
0023677076
-
Functional consequences of the arabinosylcytosine structural lesion in DNA
-
Mikita T., and Beardsley G.P. Functional consequences of the arabinosylcytosine structural lesion in DNA. Biochemistry 27 (1998) 4698-4705
-
(1998)
Biochemistry
, vol.27
, pp. 4698-4705
-
-
Mikita, T.1
Beardsley, G.P.2
-
36
-
-
27944443628
-
Cytotoxicity, cellular uptake and DNA damage by daunorubicin and its new analogues with modified daunosamine moiety
-
Ciesielska E., Studzian K., Wasowska M., Oszczapowicz I., and Szmigiero L. Cytotoxicity, cellular uptake and DNA damage by daunorubicin and its new analogues with modified daunosamine moiety. Cell Biol Toxicol 21 (2005) 139-147
-
(2005)
Cell Biol Toxicol
, vol.21
, pp. 139-147
-
-
Ciesielska, E.1
Studzian, K.2
Wasowska, M.3
Oszczapowicz, I.4
Szmigiero, L.5
-
37
-
-
33747037841
-
Molecular requirements for doxorubicin-mediated death in murine oocytes
-
Jurisicova A., Lee H.J., D'Estaing S.G., Tilly J., and Perez G.I. Molecular requirements for doxorubicin-mediated death in murine oocytes. Cell Death Differ 13 (2006) 1466-1474
-
(2006)
Cell Death Differ
, vol.13
, pp. 1466-1474
-
-
Jurisicova, A.1
Lee, H.J.2
D'Estaing, S.G.3
Tilly, J.4
Perez, G.I.5
-
38
-
-
2342623330
-
Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells
-
Kanno S., Shouji A., Hirata R., Asou K., and Ishikawa M. Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. Life Sci 75 (2004) 353-365
-
(2004)
Life Sci
, vol.75
, pp. 353-365
-
-
Kanno, S.1
Shouji, A.2
Hirata, R.3
Asou, K.4
Ishikawa, M.5
-
39
-
-
0026774240
-
A predictive model for the clinical response to low dose ara-C: a study of 102 patients with myelodysplastic syndromes or acute leukaemia
-
Hellstrom-Lindberg E., Robert K.H., Gahrton G., et al. A predictive model for the clinical response to low dose ara-C: a study of 102 patients with myelodysplastic syndromes or acute leukaemia. Br J Haematol 81 (1992) 503-511
-
(1992)
Br J Haematol
, vol.81
, pp. 503-511
-
-
Hellstrom-Lindberg, E.1
Robert, K.H.2
Gahrton, G.3
-
40
-
-
33748474416
-
Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
-
Silverman L.R., McKenzie D.R., Peterson B.L., et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 24 (2006) 3895-3903
-
(2006)
J Clin Oncol
, vol.24
, pp. 3895-3903
-
-
Silverman, L.R.1
McKenzie, D.R.2
Peterson, B.L.3
-
41
-
-
17444452612
-
Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients
-
Wijermans P., Lubbert M., Verhoef G., et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 18 (2000) 956-962
-
(2000)
J Clin Oncol
, vol.18
, pp. 956-962
-
-
Wijermans, P.1
Lubbert, M.2
Verhoef, G.3
-
42
-
-
33846820578
-
Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines
-
Berg T., Guo Y., Abdelkarim M., Fliegauf M., and Lubbert M. Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. Leuk Res 31 (2007) 497-506
-
(2007)
Leuk Res
, vol.31
, pp. 497-506
-
-
Berg, T.1
Guo, Y.2
Abdelkarim, M.3
Fliegauf, M.4
Lubbert, M.5
-
43
-
-
33747339752
-
Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
-
Reu F.J., Bae S.I., Cherkassky L., Leaman D.W., et al. Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. J Clin Oncol 24 (2006) 3771-3779
-
(2006)
J Clin Oncol
, vol.24
, pp. 3771-3779
-
-
Reu, F.J.1
Bae, S.I.2
Cherkassky, L.3
Leaman, D.W.4
-
44
-
-
0038118337
-
Effects of methylation on expression of TMS1/ASC in human breast cancer cells
-
Levine J.J., Stimson-Crider K.M., and Vertino P.M. Effects of methylation on expression of TMS1/ASC in human breast cancer cells. Oncogene 22 (2003) 3475-3488
-
(2003)
Oncogene
, vol.22
, pp. 3475-3488
-
-
Levine, J.J.1
Stimson-Crider, K.M.2
Vertino, P.M.3
-
45
-
-
0034662625
-
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
-
Hopkins-Donaldson S., Bodmer J.L., Bourloud K.B., Brognara C.B., Tschopp J., and Gross N. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 60 (2000) 4315-4319
-
(2000)
Cancer Res
, vol.60
, pp. 4315-4319
-
-
Hopkins-Donaldson, S.1
Bodmer, J.L.2
Bourloud, K.B.3
Brognara, C.B.4
Tschopp, J.5
Gross, N.6
-
46
-
-
33646419009
-
Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer
-
Deng G., Nguyen A., Tanaka H., et al. Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. Int J Cancer 118 (2006) 2999-3005
-
(2006)
Int J Cancer
, vol.118
, pp. 2999-3005
-
-
Deng, G.1
Nguyen, A.2
Tanaka, H.3
-
47
-
-
0037068353
-
DNA methylation in cancer: too much, but also too little
-
Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 21 (2002) 5400-5413
-
(2002)
Oncogene
, vol.21
, pp. 5400-5413
-
-
Ehrlich, M.1
|