메뉴 건너뛰기




Volumn 36, Issue 2, 2008, Pages 149-157

Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZAMIDE; AZACITIDINE; CASPASE; CYTARABINE; DNA; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN BCL 2;

EID: 38149088287     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.10.002     Document Type: Article
Times cited : (60)

References (47)
  • 1
    • 0036342388 scopus 로고    scopus 로고
    • Treatment of myelodysplastic syndromes with 5-azacytidine
    • Gryn J., Zeigler Z.R., Shadduck R.K., et al. Treatment of myelodysplastic syndromes with 5-azacytidine. Leuk Res 26 (2002) 893-897
    • (2002) Leuk Res , vol.26 , pp. 893-897
    • Gryn, J.1    Zeigler, Z.R.2    Shadduck, R.K.3
  • 2
    • 0027154222 scopus 로고
    • Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes
    • Silverman L.R., Holland J.F., Weinberg R.S., et al. Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia 7 Suppl 1 (1993) 21-29
    • (1993) Leukemia , vol.7 , Issue.SUPPL. 1 , pp. 21-29
    • Silverman, L.R.1    Holland, J.F.2    Weinberg, R.S.3
  • 3
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
    • Silverman L.R., Demakos E.P., Peterson B.L., et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 20 (2002) 2429-2440
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 4
    • 0037092962 scopus 로고    scopus 로고
    • Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study
    • Kornblith A.B., Herndon II J.E., Silverman L.R., et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol 20 (2002) 2441-2452
    • (2002) J Clin Oncol , vol.20 , pp. 2441-2452
    • Kornblith, A.B.1    Herndon II, J.E.2    Silverman, L.R.3
  • 5
    • 0016838872 scopus 로고
    • Kinetics and mechanisms of degradation of the antileukemic agent 5-azacytidine in aqueous solutions
    • Notari R.E., and DeYoung J.L. Kinetics and mechanisms of degradation of the antileukemic agent 5-azacytidine in aqueous solutions. J Pharm Sci 64 (1975) 1148-1157
    • (1975) J Pharm Sci , vol.64 , pp. 1148-1157
    • Notari, R.E.1    DeYoung, J.L.2
  • 6
    • 0022559050 scopus 로고
    • Determination of the antileukemia agents cytarabine and azacitidine and their respective degradation products by high-performance liquid chromatography
    • Kissinger L.D., and Stemm N.L. Determination of the antileukemia agents cytarabine and azacitidine and their respective degradation products by high-performance liquid chromatography. J Chromatogr 353 (1986) 309-318
    • (1986) J Chromatogr , vol.353 , pp. 309-318
    • Kissinger, L.D.1    Stemm, N.L.2
  • 7
    • 0023242629 scopus 로고
    • High-performance liquid chromatographic determination of 5-azacytidine in plasma
    • Rustum A.M., and Hoffman N.E. High-performance liquid chromatographic determination of 5-azacytidine in plasma. J Chromatogr 421 (1987) 387-391
    • (1987) J Chromatogr , vol.421 , pp. 387-391
    • Rustum, A.M.1    Hoffman, N.E.2
  • 8
    • 21244447049 scopus 로고    scopus 로고
    • Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies
    • Rudek M.A., Zhao M., He P., et al. Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies. J Clin Oncol 23 (2005) 3906-3911
    • (2005) J Clin Oncol , vol.23 , pp. 3906-3911
    • Rudek, M.A.1    Zhao, M.2    He, P.3
  • 10
    • 34247156577 scopus 로고    scopus 로고
    • Using LUMA: a luminometric based assay for global DNA-methylation
    • Karimi M., Johansson S., and Ekstrom T.J. Using LUMA: a luminometric based assay for global DNA-methylation. Epigenetics 1 (2006) 45-48
    • (2006) Epigenetics , vol.1 , pp. 45-48
    • Karimi, M.1    Johansson, S.2    Ekstrom, T.J.3
  • 11
    • 33744938449 scopus 로고    scopus 로고
    • LUMA (LUminometric Methylation Assay)-a high throughput method to the analysis of genomic DNA methylation
    • Karimi M., Johansson S., Stach D., et al. LUMA (LUminometric Methylation Assay)-a high throughput method to the analysis of genomic DNA methylation. Exp Cell Res 312 (2006) 1989-1995
    • (2006) Exp Cell Res , vol.312 , pp. 1989-1995
    • Karimi, M.1    Johansson, S.2    Stach, D.3
  • 12
    • 34247156577 scopus 로고    scopus 로고
    • Using LUMA: a luminometric based assay for global DNA-methylation
    • Karimi M., Johansson S., and Ekström T. Using LUMA: a luminometric based assay for global DNA-methylation. Epigenetics 1 (2006) 45-48
    • (2006) Epigenetics , vol.1 , pp. 45-48
    • Karimi, M.1    Johansson, S.2    Ekström, T.3
  • 13
    • 34247145010 scopus 로고    scopus 로고
    • Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease?
    • Stenvinkel P., Karimi M., Johansson S., et al. Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease?. J Intern Med 261 (2007) 488-499
    • (2007) J Intern Med , vol.261 , pp. 488-499
    • Stenvinkel, P.1    Karimi, M.2    Johansson, S.3
  • 14
    • 10644249986 scopus 로고    scopus 로고
    • Anticancer drug development based on modulation of the Bcl-2 family core apoptosis mechanism
    • Gardner C.R. Anticancer drug development based on modulation of the Bcl-2 family core apoptosis mechanism. Expert Rev Anticancer Ther 4 (2004) 1157-1177
    • (2004) Expert Rev Anticancer Ther , vol.4 , pp. 1157-1177
    • Gardner, C.R.1
  • 15
    • 3242778557 scopus 로고    scopus 로고
    • Differentiation-induced HL-60 cell apoptosis: a mechanism independent of mitochondrial disruption?
    • Doyle B.T., O'Neill A.J., Fitzpatrick J.M., and Watson R.W. Differentiation-induced HL-60 cell apoptosis: a mechanism independent of mitochondrial disruption?. Apoptosis 9 (2004) 345-352
    • (2004) Apoptosis , vol.9 , pp. 345-352
    • Doyle, B.T.1    O'Neill, A.J.2    Fitzpatrick, J.M.3    Watson, R.W.4
  • 16
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 17
  • 18
  • 19
    • 10044224443 scopus 로고    scopus 로고
    • Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death
    • Wang H., Yu S.W., Koh D.W., et al. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci 24 (2004) 10963-10973
    • (2004) J Neurosci , vol.24 , pp. 10963-10973
    • Wang, H.1    Yu, S.W.2    Koh, D.W.3
  • 20
    • 17144434775 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke
    • Komjati K., Mabley J.G., Virag L., Southan G.J., Salzman A.L., and Szabo C. Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. Int J Mol Med 13 (2004) 373-382
    • (2004) Int J Mol Med , vol.13 , pp. 373-382
    • Komjati, K.1    Mabley, J.G.2    Virag, L.3    Southan, G.J.4    Salzman, A.L.5    Szabo, C.6
  • 21
    • 0348109491 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity
    • Yu S.W., Wang H., Dawson T.M., and Dawson V.L. Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. Neurobiol Dis 14 (2003) 303-317
    • (2003) Neurobiol Dis , vol.14 , pp. 303-317
    • Yu, S.W.1    Wang, H.2    Dawson, T.M.3    Dawson, V.L.4
  • 22
    • 1242293646 scopus 로고    scopus 로고
    • Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution
    • Ahmad K.A., Clement M.V., Hanif I.M., and Pervaiz S. Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution. Cancer Res 64 (2004) 1452-1459
    • (2004) Cancer Res , vol.64 , pp. 1452-1459
    • Ahmad, K.A.1    Clement, M.V.2    Hanif, I.M.3    Pervaiz, S.4
  • 23
    • 0242524405 scopus 로고    scopus 로고
    • Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria
    • Clement M.V., Hirpara J.L., and Pervaiz S. Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria. Cell Death Differ 10 (2003) 1273-1285
    • (2003) Cell Death Differ , vol.10 , pp. 1273-1285
    • Clement, M.V.1    Hirpara, J.L.2    Pervaiz, S.3
  • 24
    • 0035959749 scopus 로고    scopus 로고
    • Activation of the RacGTPase inhibits apoptosis in human tumor cells
    • Pervaiz S., Cao J., Chao O.S., Chin Y.Y., and Clement M.V. Activation of the RacGTPase inhibits apoptosis in human tumor cells. Oncogene 20 (2001) 6263-6268
    • (2001) Oncogene , vol.20 , pp. 6263-6268
    • Pervaiz, S.1    Cao, J.2    Chao, O.S.3    Chin, Y.Y.4    Clement, M.V.5
  • 25
  • 26
    • 0038079767 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
    • Rosato R.R., Almenara J.A., and Grant S. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Res 63 (2003) 3637-3645
    • (2003) Cancer Res , vol.63 , pp. 3637-3645
    • Rosato, R.R.1    Almenara, J.A.2    Grant, S.3
  • 27
    • 31544448567 scopus 로고    scopus 로고
    • NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome
    • Braun T., Carvalho G., Coquelle A., et al. NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome. Blood 107 (2006) 1156-1165
    • (2006) Blood , vol.107 , pp. 1156-1165
    • Braun, T.1    Carvalho, G.2    Coquelle, A.3
  • 29
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 30
    • 0037119491 scopus 로고    scopus 로고
    • Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis
    • Robertson J.D., Enoksson M., Suomela M., Zhivotovsky B., and Orrenius S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 277 (2002) 29803-29809
    • (2002) J Biol Chem , vol.277 , pp. 29803-29809
    • Robertson, J.D.1    Enoksson, M.2    Suomela, M.3    Zhivotovsky, B.4    Orrenius, S.5
  • 31
    • 0038449141 scopus 로고    scopus 로고
    • PARP-1, a determinant of cell survival in response to DNA damage
    • Bouchard V.J., Rouleau M., and Poirier G.G. PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31 (2003) 446-454
    • (2003) Exp Hematol , vol.31 , pp. 446-454
    • Bouchard, V.J.1    Rouleau, M.2    Poirier, G.G.3
  • 32
    • 0029013514 scopus 로고
    • Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity
    • Murakami T., Li X., Gong J., Bhatia U., Traganos F., and Darzynkiewicz Z. Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity. Cancer Res 55 (1995) 3093-3098
    • (1995) Cancer Res , vol.55 , pp. 3093-3098
    • Murakami, T.1    Li, X.2    Gong, J.3    Bhatia, U.4    Traganos, F.5    Darzynkiewicz, Z.6
  • 33
    • 34250767283 scopus 로고    scopus 로고
    • 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells
    • Kiziltepe T., Hideshima T., Catley L., et al. 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells. Mol Cancer Ther 6 (2007) 1718-1727
    • (2007) Mol Cancer Ther , vol.6 , pp. 1718-1727
    • Kiziltepe, T.1    Hideshima, T.2    Catley, L.3
  • 34
    • 38149090889 scopus 로고    scopus 로고
    • Mechanisms of DNA breaks induction in vivo by 5-azacytidine: paths of micronucleus induction by azaC
    • [Epub ahead of print]
    • Morales-Ramirez P., Vallarino-Kelly T., and Cruz-Vallejo V.L. Mechanisms of DNA breaks induction in vivo by 5-azacytidine: paths of micronucleus induction by azaC. J Appl Toxicol (2007 Aug 8) [Epub ahead of print]
    • (2007) J Appl Toxicol
    • Morales-Ramirez, P.1    Vallarino-Kelly, T.2    Cruz-Vallejo, V.L.3
  • 35
    • 0023677076 scopus 로고    scopus 로고
    • Functional consequences of the arabinosylcytosine structural lesion in DNA
    • Mikita T., and Beardsley G.P. Functional consequences of the arabinosylcytosine structural lesion in DNA. Biochemistry 27 (1998) 4698-4705
    • (1998) Biochemistry , vol.27 , pp. 4698-4705
    • Mikita, T.1    Beardsley, G.P.2
  • 36
    • 27944443628 scopus 로고    scopus 로고
    • Cytotoxicity, cellular uptake and DNA damage by daunorubicin and its new analogues with modified daunosamine moiety
    • Ciesielska E., Studzian K., Wasowska M., Oszczapowicz I., and Szmigiero L. Cytotoxicity, cellular uptake and DNA damage by daunorubicin and its new analogues with modified daunosamine moiety. Cell Biol Toxicol 21 (2005) 139-147
    • (2005) Cell Biol Toxicol , vol.21 , pp. 139-147
    • Ciesielska, E.1    Studzian, K.2    Wasowska, M.3    Oszczapowicz, I.4    Szmigiero, L.5
  • 38
    • 2342623330 scopus 로고    scopus 로고
    • Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells
    • Kanno S., Shouji A., Hirata R., Asou K., and Ishikawa M. Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. Life Sci 75 (2004) 353-365
    • (2004) Life Sci , vol.75 , pp. 353-365
    • Kanno, S.1    Shouji, A.2    Hirata, R.3    Asou, K.4    Ishikawa, M.5
  • 39
    • 0026774240 scopus 로고
    • A predictive model for the clinical response to low dose ara-C: a study of 102 patients with myelodysplastic syndromes or acute leukaemia
    • Hellstrom-Lindberg E., Robert K.H., Gahrton G., et al. A predictive model for the clinical response to low dose ara-C: a study of 102 patients with myelodysplastic syndromes or acute leukaemia. Br J Haematol 81 (1992) 503-511
    • (1992) Br J Haematol , vol.81 , pp. 503-511
    • Hellstrom-Lindberg, E.1    Robert, K.H.2    Gahrton, G.3
  • 40
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman L.R., McKenzie D.R., Peterson B.L., et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 24 (2006) 3895-3903
    • (2006) J Clin Oncol , vol.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 41
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients
    • Wijermans P., Lubbert M., Verhoef G., et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 18 (2000) 956-962
    • (2000) J Clin Oncol , vol.18 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3
  • 42
    • 33846820578 scopus 로고    scopus 로고
    • Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines
    • Berg T., Guo Y., Abdelkarim M., Fliegauf M., and Lubbert M. Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. Leuk Res 31 (2007) 497-506
    • (2007) Leuk Res , vol.31 , pp. 497-506
    • Berg, T.1    Guo, Y.2    Abdelkarim, M.3    Fliegauf, M.4    Lubbert, M.5
  • 43
    • 33747339752 scopus 로고    scopus 로고
    • Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
    • Reu F.J., Bae S.I., Cherkassky L., Leaman D.W., et al. Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. J Clin Oncol 24 (2006) 3771-3779
    • (2006) J Clin Oncol , vol.24 , pp. 3771-3779
    • Reu, F.J.1    Bae, S.I.2    Cherkassky, L.3    Leaman, D.W.4
  • 44
    • 0038118337 scopus 로고    scopus 로고
    • Effects of methylation on expression of TMS1/ASC in human breast cancer cells
    • Levine J.J., Stimson-Crider K.M., and Vertino P.M. Effects of methylation on expression of TMS1/ASC in human breast cancer cells. Oncogene 22 (2003) 3475-3488
    • (2003) Oncogene , vol.22 , pp. 3475-3488
    • Levine, J.J.1    Stimson-Crider, K.M.2    Vertino, P.M.3
  • 45
    • 0034662625 scopus 로고    scopus 로고
    • Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • Hopkins-Donaldson S., Bodmer J.L., Bourloud K.B., Brognara C.B., Tschopp J., and Gross N. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 60 (2000) 4315-4319
    • (2000) Cancer Res , vol.60 , pp. 4315-4319
    • Hopkins-Donaldson, S.1    Bodmer, J.L.2    Bourloud, K.B.3    Brognara, C.B.4    Tschopp, J.5    Gross, N.6
  • 46
    • 33646419009 scopus 로고    scopus 로고
    • Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer
    • Deng G., Nguyen A., Tanaka H., et al. Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. Int J Cancer 118 (2006) 2999-3005
    • (2006) Int J Cancer , vol.118 , pp. 2999-3005
    • Deng, G.1    Nguyen, A.2    Tanaka, H.3
  • 47
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: too much, but also too little
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 21 (2002) 5400-5413
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.