Allosteric inhibition of the neuropeptidase neurolysin

Journal of Biological Chemistry

Volumn 289, Issue 51, 2014, Pages 35605-35619

  Hines, Christina S ^a   Ray, Kallol ^a   Schmidt, Jack J ^a   Xiong, Fei ^a   Feenstra, Rolf W ^b   Pras raves, Mia ^b   De Moes, Jan Peter ^b   Lange, Jos H M ^b   Melikishvili, Manana ^a   Fried, Michael G ^a   Mortenson, Paul ^c   Charlton, Michael ^c   Patel, Yogendra ^c   Courtney, Stephen M ^c   Kruse, Chris G ^b   Rodgers, David W ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Chemical Design and Synthesis Unit   (Netherlands)

^c EVOTEC UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

ALLOSTERIC INHIBITION; ANGIOTENSIN-CONVERTING ENZYME; BIOACTIVE PEPTIDES; CONFORMATIONAL CHANGE; ENDOCRINE SYSTEMS; FLUORESCENCE POLARIZATION; INHIBITION KINETICS; SUBSTRATE BINDING;

ENZYMES;

3 [1 [3 (2 CHLOROPHENYL) 2 (2 FLUOROPHENYL)PYRAZOLIDIN 1 YL] 1 OXOPROPAN 2 YL] 1 (ADAMANTAN 2 YL)UREA; METALLOPROTEINASE INHIBITOR; NEUROLYSIN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; METALLOPROTEINASE; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE POLARIZATION; INHIBITION KINETICS; PROTEIN CLEAVAGE; ANIMAL; BINDING SITE; BIOCATALYSIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE; RAT; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FLUORESCENCE POLARIZATION; KINETICS; METALLOENDOPEPTIDASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; SUBSTRATE SPECIFICITY;

EID: 84919360730     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.620930     Document Type: Article

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