메뉴 건너뛰기




Volumn 9, Issue 12, 2014, Pages

Resveratrol enhances palmitate-induced ER stress and apoptosis in cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; RESVERATROL; TRIACYLGLYCEROL; X BOX BINDING PROTEIN 1; ACYL COENZYME A DESATURASE; ANTINEOPLASTIC AGENT; DDIT3 PROTEIN, HUMAN; DNA BINDING PROTEIN; PALMITIC ACID DERIVATIVE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SCD1 PROTEIN, HUMAN; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR;

EID: 84919340292     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113929     Document Type: Article
Times cited : (49)

References (55)
  • 2
    • 53849103951 scopus 로고    scopus 로고
    • The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells
    • Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ (2008) The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells. Biochem Soc Trans 36: 905-908.
    • (2008) Biochem Soc Trans , vol.36 , pp. 905-908
    • Morgan, N.G.1    Dhayal, S.2    Diakogiannaki, E.3    Welters, H.J.4
  • 3
    • 0034612153 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: Prevention by cyclosporin A
    • Kong JY, Rabkin SW (2000) Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: Prevention by cyclosporin A. Biochim Biophys Acta - Mol Cell Biol Lipids. 1485: 45-55.
    • (2000) Biochim Biophys Acta - Mol Cell Biol Lipids , vol.1485 , pp. 45-55
    • Kong, J.Y.1    Rabkin, S.W.2
  • 4
    • 33745828301 scopus 로고    scopus 로고
    • Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
    • Wei Y, Wang D, Topczewski F, Pagliassotti MJ (2006) Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 291: E275-E281.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. E275-E281
    • Wei, Y.1    Wang, D.2    Topczewski, F.3    Pagliassotti, M.J.4
  • 5
    • 76749101133 scopus 로고    scopus 로고
    • Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells
    • Zhang L, Seitz LC, Abramczyk AM, Chan C (2010) Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells. Exp Cell Res 316: 716-727.
    • (2010) Exp Cell Res , vol.316 , pp. 716-727
    • Zhang, L.1    Seitz, L.C.2    Abramczyk, A.M.3    Chan, C.4
  • 6
    • 77957124257 scopus 로고    scopus 로고
    • Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: Involvement of cAMP/protein kinase A and AMP-activated protein kinase
    • Kim J-E, Song SE, Kim Y-W, Kim J-Y, Park S-C, et al. (2010) Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase. J Endocrinol 207: 35-44.
    • (2010) J Endocrinol , vol.207 , pp. 35-44
    • Kim, J.-E.1    Song, S.E.2    Kim, Y.-W.3    Kim, J.-Y.4    Park, S.-C.5
  • 7
    • 77950821179 scopus 로고    scopus 로고
    • Linking endoplasmic reticulum stress to cell death in hepatocytes: Roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
    • Pfaffenbach KT, Gentile CL, Nivala AM, Wang D, Wei Y, et al. (2010) Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am J Physiol Endocrinol Metab 298: E1027-E1035.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E1027-E1035
    • Pfaffenbach, K.T.1    Gentile, C.L.2    Nivala, A.M.3    Wang, D.4    Wei, Y.5
  • 8
    • 79952701894 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis
    • Ibrahim SH, Akazawa Y, Cazanave SC, Bronk SF, Elmi NA, et al. (2011) Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. J Hepatol 54: 765-772.
    • (2011) J Hepatol , vol.54 , pp. 765-772
    • Ibrahim, S.H.1    Akazawa, Y.2    Cazanave, S.C.3    Bronk, S.F.4    Elmi, N.A.5
  • 9
    • 78751556358 scopus 로고    scopus 로고
    • Control of NF-κB and inflammation by the unfolded protein response
    • Kitamura M (2011) Control of NF-κB and inflammation by the unfolded protein response. Int Rev Immunol 30: 4-15.
    • (2011) Int Rev Immunol , vol.30 , pp. 4-15
    • Kitamura, M.1
  • 10
    • 70349352744 scopus 로고    scopus 로고
    • Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    • Santos CXC, Tanaka LY, Wosniak J, Laurindo FRM (2009) Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 11: 2409-2427.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2409-2427
    • Santos, C.X.C.1    Tanaka, L.Y.2    Wosniak, J.3    Laurindo, F.R.M.4
  • 11
    • 10644233167 scopus 로고    scopus 로고
    • CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
    • Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, et al. (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18: 3066-3077.
    • (2004) Genes Dev , vol.18 , pp. 3066-3077
    • Marciniak, S.J.1    Yun, C.Y.2    Oyadomari, S.3    Novoa, I.4    Zhang, Y.5
  • 12
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
    • McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259.
    • (2001) Mol Cell Biol , vol.21 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.O.3    Aw, T.Y.4    Holbrook, N.J.5
  • 13
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
    • (1999) Nature , vol.397 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 14
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5
  • 15
    • 80054064688 scopus 로고    scopus 로고
    • Protective potential of resveratrol against oxidative stress and apoptosis in Batten disease lymphoblast cells
    • Yoon DH, Kwon OY, Mang JY, Jung MJ, Kim DY, et al. (2011) Protective potential of resveratrol against oxidative stress and apoptosis in Batten disease lymphoblast cells. Biochem Biophys Res Commun 414: 49-52.
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 49-52
    • Yoon, D.H.1    Kwon, O.Y.2    Mang, J.Y.3    Jung, M.J.4    Kim, D.Y.5
  • 16
    • 79955661493 scopus 로고    scopus 로고
    • Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
    • Li Y, Xu S, Giles A, Nakamura K, Lee JW, et al. (2011) Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J 25: 1664-1679.
    • (2011) FASEB J , vol.25 , pp. 1664-1679
    • Li, Y.1    Xu, S.2    Giles, A.3    Nakamura, K.4    Lee, J.W.5
  • 17
    • 80052827034 scopus 로고    scopus 로고
    • Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells
    • Wang FM, Galson DL, Roodman GD, Ouyang H (2011) Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells. Exp Hematol 39: 999-1006.
    • (2011) Exp Hematol , vol.39 , pp. 999-1006
    • Wang, F.M.1    Galson, D.L.2    Roodman, G.D.3    Ouyang, H.4
  • 18
    • 72949115257 scopus 로고    scopus 로고
    • Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation
    • Liu BQ, Gao YY, Niu XF, Xie JS, Meng X, et al. (2010) Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation. Biochem Biophys Res Commun 391: 778-782.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 778-782
    • Liu, B.Q.1    Gao, Y.Y.2    Niu, X.F.3    Xie, J.S.4    Meng, X.5
  • 19
    • 35848970056 scopus 로고    scopus 로고
    • Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
    • Lin C-L, Huang H-C, Lin J-K (2007) Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J Lipid Res 48: 2334-2343.
    • (2007) J Lipid Res , vol.48 , pp. 2334-2343
    • Lin, C.-L.1    Huang, H.-C.2    Lin, J.-K.3
  • 20
    • 60549098942 scopus 로고    scopus 로고
    • Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway
    • Wang GL, Fu YC, Xu WC, Feng YQ, Fang SR, et al. (2009) Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway. Biochem Biophys Res Commun 380: 644-649.
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 644-649
    • Wang, G.L.1    Fu, Y.C.2    Xu, W.C.3    Feng, Y.Q.4    Fang, S.R.5
  • 21
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3    Jamieson, H.A.4    Lerin, C.5
  • 23
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
    • Jang M, Cai L, Udeani GO, Slowing K V, Thomas CF, et al. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220.
    • (1997) Science , vol.275 , pp. 218-220
    • Jang, M.1    Cai, L.2    Udeani, G.O.3    Slowing, K.V.4    Thomas, C.F.5
  • 24
    • 0034790052 scopus 로고    scopus 로고
    • Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity
    • Park JW, Choi YJ, Suh SI, Baek WK, Suh MH, et al. (2001) Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis 22: 1633-1639.
    • (2001) Carcinogenesis , vol.22 , pp. 1633-1639
    • Park, J.W.1    Choi, Y.J.2    Suh, S.I.3    Baek, W.K.4    Suh, M.H.5
  • 25
    • 0035835490 scopus 로고    scopus 로고
    • Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells
    • Park JW, Choi YJ, Jang MA, Lee YS, Jun DY, et al. (2001) Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells. Cancer Lett 163: 43-49.
    • (2001) Cancer Lett , vol.163 , pp. 43-49
    • Park, J.W.1    Choi, Y.J.2    Jang, M.A.3    Lee, Y.S.4    Jun, D.Y.5
  • 26
    • 33645464650 scopus 로고    scopus 로고
    • Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
    • Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, et al. (2006) Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 5: 621-629.
    • (2006) Mol Cancer Ther , vol.5 , pp. 621-629
    • Kotha, A.1    Sekharam, M.2    Cilenti, L.3    Siddiquee, K.4    Khaled, A.5
  • 28
    • 44849137874 scopus 로고    scopus 로고
    • Sugar and fat - That's where it's at: Metabolic changes in tumors
    • Young CD, Anderson SM (2008) Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res 10: 202.
    • (2008) Breast Cancer Res , vol.10 , pp. 202
    • Young, C.D.1    Anderson, S.M.2
  • 30
    • 0028805667 scopus 로고
    • Membrane fatty acids of breast carcinoma: Contribution of host fatty acids and tumor properties
    • Chajès V, Lanson M, Fetissof F, Lhuillery C, Bougnoux P (1995) Membrane fatty acids of breast carcinoma: contribution of host fatty acids and tumor properties. Int J Cancer 63: 169-175.
    • (1995) Int J Cancer , vol.63 , pp. 169-175
    • Chajès, V.1    Lanson, M.2    Fetissof, F.3    Lhuillery, C.4    Bougnoux, P.5
  • 32
    • 33846670434 scopus 로고    scopus 로고
    • Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue
    • Szachowicz-Petelska B, Sulkowski S, Figaszewski ZA (2007) Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue. Mol Cell Biochem 294: 237-242.
    • (2007) Mol Cell Biochem , vol.294 , pp. 237-242
    • Szachowicz-Petelska, B.1    Sulkowski, S.2    Figaszewski, Z.A.3
  • 34
    • 0041842553 scopus 로고    scopus 로고
    • Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: Any single lysine or lysine pair of the small subunit is sufficient for ubiquitination
    • Chen L, Smith L, Wang Z, Smith JB (2003) Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination. Mol Pharmacol 64: 334-345.
    • (2003) Mol Pharmacol , vol.64 , pp. 334-345
    • Chen, L.1    Smith, L.2    Wang, Z.3    Smith, J.B.4
  • 35
    • 36749081135 scopus 로고    scopus 로고
    • Resveratrol as an antioxidant and pro-oxidant agent: Mechanisms and clinical implications
    • De la Lastra CA, Villegas I (2007) Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem Soc Trans 35: 1156-1160.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1156-1160
    • De La Lastra, C.A.1    Villegas, I.2
  • 36
    • 68049142428 scopus 로고    scopus 로고
    • Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    • Peter A, Weigert C, Staiger H, Machicao F, Schick F, et al. (2009) Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes 58: 1757-1765.
    • (2009) Diabetes , vol.58 , pp. 1757-1765
    • Peter, A.1    Weigert, C.2    Staiger, H.3    Machicao, F.4    Schick, F.5
  • 37
    • 78650725619 scopus 로고    scopus 로고
    • Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells
    • Minville-Walz M, Pierre A-S, Pichon L, Bellenger S, Fèvre C, et al. (2010) Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLoS One 5: e14363.
    • (2010) PLoS One , vol.5 , pp. e14363
    • Minville-Walz, M.1    Pierre, A.-S.2    Pichon, L.3    Bellenger, S.4    Fèvre, C.5
  • 38
    • 79955611314 scopus 로고    scopus 로고
    • Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice
    • Kim S, Jin Y, Choi Y, Park T (2011) Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochem Pharmacol 81: 1343-1351.
    • (2011) Biochem Pharmacol , vol.81 , pp. 1343-1351
    • Kim, S.1    Jin, Y.2    Choi, Y.3    Park, T.4
  • 39
    • 84865090762 scopus 로고    scopus 로고
    • Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
    • Chen S, Xiao X, Feng X, Li W, Zhou N, et al. (2012) Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression. J Nutr Biochem 23: 1100-1112.
    • (2012) J Nutr Biochem , vol.23 , pp. 1100-1112
    • Chen, S.1    Xiao, X.2    Feng, X.3    Li, W.4    Zhou, N.5
  • 40
    • 34248571826 scopus 로고    scopus 로고
    • GRP78 induction in cancer: Therapeutic and prognostic implications
    • Lee AS (2007) GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 67: 3496-3499.
    • (2007) Cancer Res , vol.67 , pp. 3496-3499
    • Lee, A.S.1
  • 41
    • 68749112705 scopus 로고    scopus 로고
    • Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
    • Luo J, Solimini NL, Elledge SJ (2009) Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction. Cell 138: 807.
    • (2009) Cell , vol.138 , pp. 807
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 42
    • 77953387854 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress response in cancer: Molecular mechanism and therapeutic potential
    • Wang G, Yang ZQ, Zhang K (2010) Endoplasmic reticulum stress response in cancer: Molecular mechanism and therapeutic potential. Am J Transl Res 2: 65-74.
    • (2010) Am J Transl Res , vol.2 , pp. 65-74
    • Wang, G.1    Yang, Z.Q.2    Zhang, K.3
  • 44
    • 33745728461 scopus 로고    scopus 로고
    • Fatty acid synthase and cancer: New application of an old pathway
    • Kuhajda FP (2006) Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 66: 5977-5980.
    • (2006) Cancer Res , vol.66 , pp. 5977-5980
    • Kuhajda, F.P.1
  • 45
    • 81755173915 scopus 로고    scopus 로고
    • Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
    • Roongta U V, Pabalan JG, Wang X, Ryseck R-P, Fargnoli J, et al. (2011) Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res 9: 1551-1561.
    • (2011) Mol Cancer Res , vol.9 , pp. 1551-1561
    • Roongta, U.V.1    Pabalan, J.G.2    Wang, X.3    Ryseck, R.-P.4    Fargnoli, J.5
  • 47
    • 33645506335 scopus 로고    scopus 로고
    • Identification of mouse palmitoyl-coenzyme A Delta9-desaturase
    • Miyazaki M, Bruggink SM, Ntambi JM (2006) Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J Lipid Res 47: 700-704.
    • (2006) J Lipid Res , vol.47 , pp. 700-704
    • Miyazaki, M.1    Bruggink, S.M.2    Ntambi, J.M.3
  • 48
    • 77954579285 scopus 로고    scopus 로고
    • Decrease in membrane phospholipid unsaturation induces unfolded protein response
    • Ariyama H, Kono N, Matsuda S, Inoue T, Arai H (2010) Decrease in membrane phospholipid unsaturation induces unfolded protein response. J Biol Chem 285: 22027-22035.
    • (2010) J Biol Chem , vol.285 , pp. 22027-22035
    • Ariyama, H.1    Kono, N.2    Matsuda, S.3    Inoue, T.4    Arai, H.5
  • 49
    • 77957121400 scopus 로고    scopus 로고
    • Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells
    • Thörn K, Hovsepyan M, Bergsten P (2010) Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells. Lipids Health Dis 9: 108.
    • (2010) Lipids Health Dis , vol.9 , pp. 108
    • Thörn, K.1    Hovsepyan, M.2    Bergsten, P.3
  • 50
    • 84863388391 scopus 로고    scopus 로고
    • SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids
    • Mason P, Liang B, Li L, Fremgen T, Murphy E, et al. (2012) SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS One 7: e33823.
    • PLoS One , vol.7 , pp. e33823
    • Mason, P.1    Liang, B.2    Li, L.3    Fremgen, T.4    Murphy, E.5
  • 51
    • 33845575826 scopus 로고    scopus 로고
    • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    • Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, et al. (2006) Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res 47: 2726-2737.
    • (2006) J Lipid Res , vol.47 , pp. 2726-2737
    • Borradaile, N.M.1    Han, X.2    Harp, J.D.3    Gale, S.E.4    Ory, D.S.5
  • 52
    • 78049475228 scopus 로고    scopus 로고
    • Effects of resveratrol on membrane biophysical properties: Relevance for its pharmacological effects
    • Brittes J, Lucio M, Nunes C, Lima JLFC, Reis S (2010) Effects of resveratrol on membrane biophysical properties: Relevance for its pharmacological effects. Chem Phys Lipids 163: 747-754.
    • (2010) Chem Phys Lipids , vol.163 , pp. 747-754
    • Brittes, J.1    Lucio, M.2    Nunes, C.3    Jlfc, L.4    Reis, S.5
  • 53
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32: 1377-1382.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    DeLegge, M.H.3    Oatis, J.E.4    Walle, U.K.5
  • 55
    • 74949110443 scopus 로고    scopus 로고
    • Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: Rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation
    • Mayer CM, Belsham DD (2010) Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation. Endocrinology 151: 576-585.
    • (2010) Endocrinology , vol.151 , pp. 576-585
    • Mayer, C.M.1    Belsham, D.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.