C5-curcuminoid-4-aminoquinoline based molecular hybrids: Design, synthesis and mechanistic investigation of anticancer activity

New Journal of Chemistry

Volumn 39, Issue 1, 2015, Pages 224-234

  Kandi, Shamseer Kulangara ^a   Manohar, Sunny ^a   Vélez Gerena, Christian E ^b   Zayas, Beatriz ^b   Malhotra, Sanjay V ^c   Rawat, Diwan S ^a  

^a UNIVERSITY OF DELHI   (India)

^b UNIVERSIDAD METROPOLITANA   (Puerto Rico)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(3,4 DIMETHOXYBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(4 ETHYLBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(4 FLUOROBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(4 METHOXYBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(4 METHYLBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPLY] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(4 METHYLBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(4 ETHYLBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] 3,5 BIS(4 FLUOROBENZYLIDENE)PIPERIDIN 4 ONE; 1 [[1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4YL]METHYL] 3,5 BIS(3,4 DIMETHOXYBENZYLIDENE)PIPERIDIN 4 ONE; 3,5 BIS(3 BROMOBENZYLIDENE) 1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERIDIN 4 ONE; 3,5 BIS(4 BROMOBENZYLIDENE) 1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERIDIN 4 ONE; 3,5 BIS(4 BROMOBENZYLIDENE) 1 [[1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPLYL] 1H 1,2,3 TIRAZOL 4 YL]METHYL]PIPERIDIN 4 ONE; 3,5 BIS(4 CHLOROBENZYLIDENE) 1 [[1 [2 [(7 CHLOROQUINOLIN 4 YL)AMINO]ETHYL] 1H 1,2,3 TRIAZOL 4 YL)METHYL]PIPERIDIN 4 ONE; 3,5 BIS(4 CHLOROBENZYLIDENE) 1 [[1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERIDIN 4 ONE; 4 AMINOQUINOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CURCUMIN; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PHARMACOPHORE;

EID: 84919338553     PISSN: 11440546     EISSN: 13699261     Source Type: Journal    
DOI: 10.1039/c4nj00936c     Document Type: Article

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