PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9

Apoptosis

Volumn 18, Issue 9, 2013, Pages 1071-1082

  Ding, Ying ^a   Nguyen, Thu Annelise ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Bcl 2 family; Caspases; PQ1; Quinoline derivative

Indexed keywords

CASPASE 8; CASPASE 9; CYTOCHROME C; PQ 1; PROTEIN BAX; PROTEIN BCL 2; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; QUINOLINE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CYTOSOL; DOSE RESPONSE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; WESTERN BLOTTING; BREAST NEOPLASMS; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; PATHOPHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; BREAST NEOPLASMS; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; ENZYME ACTIVATION; FEMALE; HUMANS; MITOCHONDRIA; QUINOLINES;

EID: 84881478108     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0855-1     Document Type: Article

References (33)

1. Solomon VR, Lee H (2011) Quinoline as a privileged scaffold in cancer drug discovery. Curr Med Chem 18:1488-1508
2. Ganguly A, Banerjee K, Chakraborty P et al (2011) Overcoming multidrug resistance (MDR) in cancer in vitro and in vivo by a quinoline derivative. Biomed Pharmacother 65:387-394
3. Tseng CH, Tzeng CC, Chung KY et al (2011) Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives. Bioorg Med Chem 19:7653-7663
4. Sharma S, Panjamurthy K, Choudhary B et al (2011) A novel DNA intercalator, 8-methoxy pyrimido[4′,5′:4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor. Mol Carcinog 52:413-425
5. Collins MK, Lopez Rivas A (1993) The control of apoptosis in mammalian cells. Trends Biochem Sci 18:307-309
6. Franceschi C (1989) Cell proliferation, cell death and aging. Aging (Milano) 1:3-15
7. Wyllie AH (1992) Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev 11:95-103
8. Chabner BA (1993) Biological basis for cancer treatment. Ann Intern Med 118:633-637
9. Kemnitzer W, Kuemmerle J, Jiang S et al (2008) Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: structure-activity relationships of the 1- and 3-positions. Bioorg Med Chem Lett 18:6259-6264
10. Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495-516
11. Zimmermann KC, Green DR (2001) How cells die: apoptosis pathways. J Allergy Clin Immunol 108:S99-S103
12. Kruidering M, Evan GI (2000) Caspase-8 in apoptosis: the beginning of "the end"? IUBMB Life 50:85-90
13. Gakhar G, Ohira T, Shi A, Hua DH, Nguyen TA (2008) Antitumor effect of substituted quinolines in breast cancer cells. Drug Dev Res 69:526-534
14. Shi A, Nguyen TA, Battina SK et al (2008) Synthesis and anti-breast cancer activities of substituted quinolines. Bioorg Med Chem Lett 18:3364-3368
15. Cryns V, Yuan J (1998) Proteases to die for. Genes Dev 12:1551-1570
16. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326(Pt 1):1-16
17. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
18. Fisher DE (1994) Apoptosis in cancer therapy: crossing the threshold. Cell 78:539-542
19. Li P, Nijhawan D, Budihardjo I et al (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489
20. Zhivotovsky B, Samali A, Gahm A, Orrenius S (1999) Caspases: their intracellular localization and translocation during apoptosis. Cell Death Differ 6:644-651
21. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15:269-290
22. Zhou Q, McCracken MA, Strobl JS (2002) Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agents. Breast Cancer Res Treat 75:107-117
23. Kim YH, Shin KJ, Lee TG et al (2005) G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound. Biochem Pharmacol 69:1333-1341
24. Alnemri ES, Livingston DJ, Nicholson DW et al (1996) Human ICE/CED-3 protease nomenclature. Cell 87:171
25. Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-1316
26. Van de Craen M, Van Loo G, Pype S et al (1998) Identification of a new caspase homologue: caspase-14. Cell Death Differ 5:838-846
27. Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99-104
28. Salvesen GS (2002) Caspases: opening the boxes and interpreting the arrows. Cell Death Differ 9:3-5
29. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
30. Hsu YT, Youle RJ (1997) Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem 272:13829-13834
31. Knudson CM, Korsmeyer SJ (1997) Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16:358-363
32. Scaffidi C, Fulda S, Srinivasan A et al (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1687
33. Li H, Zhu H, Xu CJ, Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501