Synthesis, characterization and structure-activity relationship of novel N-phosphorylated E,E-3,5-bis(thienylidene)piperid-4-ones

European Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2010, Pages 992-1000

  Makarov, Michael V ^a   Leonova, Evgeniya S ^a   Rybalkina, Ekaterina Yu ^b   Tongwa, Paul ^c   Khrustalev, Victor N ^a,c   Timofeeva, Tatiana V ^c   Odinets, Irina L ^a  

^a A N NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c NEW MEXICO HIGHLANDS UNIVERSITY   (United States)

Author keywords

4 Piperidones; Aminophosphonates; Cytotoxicity structure relationship; N Phosphoryl 3,5 bis(thienylidene)piperid 4 ones; N Phosphorylalkylene 3,5 bis(thienylidene)piperid 4 ones; Photoisomerization; Synthesis; X ray structure

Indexed keywords

DIETHYL 2 [4 OXO 3,5 BIS(2 THIENYLMETHYLENE) 1 PIPERIDINYL]ETHYLPHOSPHONATE; DIETHYL 2 [4 OXO 3,5 BIS(2 THIENYLMETHYLENE) 1 PIPERIDINYL]METHYLPHOSPHONATE; DIETHYL 2 [4 OXO 3,5 BIS(2 THIENYLMETHYLENE) 1 PIPERIDINYL]PROPYLPHOSPHONATE; DIETHYL 4 OXO 3,5 BIS(2 THIENYLYDENE) 1 PIPERIDINYLPHOSPHONATE; DIPHENYL 4 OXO 3,5 BIS(2 THIENYLYDENE) 1 PIPERIDINYLPHOSPHONATE; O PHENYLMETHYL[4 OXO 3,5 BIS(2 THIENYLMETHYLENE) 1 PIPERIDINYL]PHOSPHINATE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PHOSPHORYLATION; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; THERMODYNAMICS; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITROGEN; OVARIAN NEOPLASMS; PHOSPHORYLATION; PIPERIDONES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 75849164993     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.041     Document Type: Article

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