Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium

Biochimie

Volumn 93, Issue 3, 2011, Pages 506-512

  Deqiu, Zhu ^a,b   Kang, Liu ^c   Jiali, Yi ^c   Baolin, Liu ^c   Gaolin, Liu ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Endothelium; Inflammation; Insulin resistance; Luteolin

Indexed keywords

BETA ACTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; LUTEOLIN; NITRIC OXIDE; PALMITIC ACID; PROTEIN KINASE B; SERINE; THREONINE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; NONHUMAN; RAT; SIGNAL TRANSDUCTION; VASODILATATION;

ANIMALS; AORTA; CYTOKINES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; INFLAMMATION; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; LUTEOLIN; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PALMITATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SERINE; SIGNAL TRANSDUCTION; VASODILATION;

RATTUS;

EID: 79951515436     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.11.002     Document Type: Article

References (29)

1. T.A. Buchanan Pancreatic beta-cell loss and preservation in type 2 diabetes Clin. Ther. 25 Suppl. B 2003 32 46
2. T. McLaughlin, G. Allison, and F. Abbasi Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals Metabolism 53 2004 495 499 (Pubitemid 38419194)
3. G. Zeng, and M.J. Quon Insulin-stimulated production of nitric oxide is inhibited by wortmannin: direct measurement in vascular endothelial cells J. Clin. Invest. 98 1996 894 898 (Pubitemid 26293305)
4. A.J. Lusis Atherosclerosis Nature 407 2000 233 241
5. J. Calles-Escandon, and M. Cipolla Diabetes and endothelial dysfunction: a clinical perspective Endocr. Rev. 22 2001 36 52 (Pubitemid 32187802)
6. T. Kaneko, and N. Baba Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity Biosci. Biotechnol. Biochem. 63 1999 323 328 (Pubitemid 129548678)
7. T. Kozakai, A. Yamanaka, and T. Ichiba Luteolin inhibits endothelin-1 secretion in cultured endothelial cells Biosci. Biotechnol. Biochem. 69 2005 1613 1615 (Pubitemid 41207356)
8. Y. Takano-Ishikawa, M. Goto, and K. Yamaki Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha Phytother. Res. 17 2003 1224 1227 (Pubitemid 38057185)
9. Y.J. Jeong, Y.J. Choi, and J.S. Choi Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL Br. J. Nutr. 97 2007 447 457
10. S. Junna, L. Kang, and Y. Jiali Luteolin inhibits lysophosphatidylcholine-induced apoptosis in endothelial cells by a calcium/mitochondrion/caspase-dependent pathway Planta Med. 76 2010 433 438
11. G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance Science 259 1993 87 91 (Pubitemid 23036092)
12. M. Yuan, N. Konstantopoulos, and J. Lee Reversal of obesity- and diet-induced insulin resistance with sodium salicylates or targeted disruption of Ikk Science 293 2001 1673 1677 (Pubitemid 32807849)
13. C.C. Chen, M.P. Chow, and W.C. Huang Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappa B: structure-activity relationships Mol. Pharmacol. 66 2004 683 693
14. L. Ziyan, Z. Yongmei, and Z. Nan Evaluation of the anti-inflammatory activity of luteolin in experimental animal models Planta Med. 73 2007 221 226 (Pubitemid 46917473)
15. B.B. Kahn, and J.S. Flier Obesity and insulin resistance J. Clin. Invest. 106 2000 473 481 (Pubitemid 30666380)
16. T.T. Lam, G. Van De Werve, and A. Giacca Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites Am. J. Physiol. Endocrinol. Metab. 284 2003 281 290
17. A. Dresner, D. Laurent, and M.E. M.MarcucciGriffin Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity J. Clin. Invest. 103 1999 253 259 (Pubitemid 29053143)
18. R.H. Knopp, B. Retzlaff, and C. Walden One-year effects of increasingly fat-restricted, carbohydrate-enriched diets on lipoprotein levels in free-living subjects Proc. Soc. Exp. Biol. Med. 225 2000 191 199 (Pubitemid 32041499)
19. R. Luostarinen, M. Boberg, and T. Saldeen Fatty acid composition in total phospholipids of human coronary arteries in sudden cardiac death Atherosclerosis 99 1993 187 193 (Pubitemid 23130290)
20. V. Calderone, S. Chericoni, and C. Martinelli Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels Naunyn Schmiedebergs Arch. Pharmacol. 370 2004 290 298 (Pubitemid 40063828)
21. S. Hang, V. Maia, and K.I. Kokoeva TLR4 links innate immunity and fatty acid-induced insulin resistance J. Clin. Invest. 116 2006 3015 3025
22. F. Kim, M. Pham, and I. Luttrell Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity Circ. Res. 100 2007 1589 1596 (Pubitemid 46897262)
23. P.P. Tak, and G.S. Firestein NF-κB: a key role in inflammatory diseases J. Clin. Invest. 107 2001 7 11 (Pubitemid 32047405)
24. Z. Gao, D. Hwang, and F. Bataille Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex J. Biol. Chem. 277 2002 48115 48121 (Pubitemid 35470759)
25. K. Ishizuka, I. Usui, and Y. Kanatani Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes Endocrinology 148 2007 2994 3003 (Pubitemid 46984801)
26. A. Herschkovitz, Y.F. Liu, and E. Ilan Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance J. Biol. Chem. 282 2007 18018 18027 (Pubitemid 47100249)
27. G. Zhanguo, Z. Aamir, and J. Michael Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases J. Biol. Chem. 27 2003 24944 24950
28. G. Zeng, F.H. Nystrom, and L.V. Ravichandran Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells Circulation 101 2000 1539 1545 (Pubitemid 30180890)
29. J.D. Symons, S.L. McMillin, and C. Riehle Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure Circ. Res. 104 2009 1085 1094