Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress

Pharmacological Research

Volumn 61, Issue 4, 2010, Pages 281-287

  Qian, Ling Bo ^a   Wang, Hui Ping ^a   Chen, Ying ^a   Chen, Fang Xia ^a   Ma, Yan Yan ^a   Bruce, Iain C ^a   Xia, Qiang ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Aorta; Endothelium; High glucose; Luteolin; Oxidative stress; Vasorelaxation

Indexed keywords

ACETYLCHOLINE; GLUCOSE; HYDROXYL RADICAL; INDOMETACIN; LUTEOLIN; MANNITOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; LOW DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; THORACIC AORTA; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; DIABETES MELLITUS, EXPERIMENTAL; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; GLUCOSE; LUTEOLIN; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 77649336818     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.10.004     Document Type: Article

References (39)

1. Wild S., Roglic G., Green A., Sicree R., and King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diab Care 27 (2004) 1047-1053
2. Rodriguez-Manas L., Angulo J., Vallejo S., Peiro C., Sanchez-Ferrer A., Cercas E., et al. Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature. Diabetologia 46 (2003) 556-566
3. Farhangkhoee H., Khan Z.A., Kaur H., Xin X., Chen S., and Chakrabarti S. Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets. Pharmacol Ther 111 (2006) 384-399
4. Ellis A., Cheng Z.J., Li Y., Jiang Y.F., Yang J., Pannirselvam M., et al. Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature. Eur J Pharmacol 601 (2008) 111-117
5. + ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest 90 (1992) 727-732
6. Pieper G.M., Siebeneich W., Olds C.L., Felix C.C., and Del Soldato P. Vascular protective actions of a nitric oxide aspirin analog in both in vitro and in vivo models of diabetes mellitus. Free Radic Biol Med 32 (2002) 1143-1156
7. Qian L.B., Wang H.P., Qiu W.L., Huang H., Bruce I.C., and Xia Q. Interleukin-2 protects against endothelial dysfunction induced by high glucose levels in rats. Vasc Pharmacol 45 (2006) 374-382
8. Giugliano D., Ceriello A., and Paolisso G. Oxidative stress and diabetic vascular complications. Diab Care 19 (1996) 257-267
9. Cai H., and Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87 (2000) 840-844
10. Marchioli R., Schweiger C., Levantesi G., Tavazzi L., and Valagussa F. Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data. Lipids 36 suppl. (2001) S53-S63
11. Heart Protection Study Collaborative G. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360 (2002) 23-33
12. Lonn E., Yusuf S., Hoogwerf B., Pogue J., Yi Q., Zinman B., et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diab Care 25 (2002) 1919-1927
13. Graf B.A., Milbury P.E., and Blumberg J.B. Flavonols, flavones, flavanones, and human health: epidemiological evidence. J Med Food 8 (2005) 281-290
14. Loizzo M.R., Said A., Tundis R., Rashed K., Statti G.A., Hufner A., et al. Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae). Phytother Res 21 (2007) 32-36
15. Choi J.S., Choi Y.J., Park S.H., Kang J.S., and Kang Y.H. Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B. J Nutr 134 (2004) 1013-1019
16. Ma X., Li Y.F., Gao Q., Ye Z.G., Lu X.J., Wang H.P., et al. Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery. Life Sci 83 (2008) 110-117
17. Jiang H., Xia Q., Xu W., and Zheng M. Chrysanthemum morifolium attenuated the reduction of contraction of isolated rat heart and cardiomyocytes induced by ischemia/reperfusion. Pharmazie 59 (2004) 565-567
18. Jiang H.D., Cai J., Xu J.H., Zhou X.M., and Xia Q. Endothelium-dependent and direct relaxation induced by ethyl acetate extract from Flos Chrysanthemi in rat thoracic aorta. J Ethnopharmacol 101 (2005) 221-226
19. + exchanger inhibitor prevented endothelial dysfunction induced by high glucose. J Cardiovasc Pharmacol 45 (2005) 586-590
20. Li J., Li W., Liu W., Altura B.T., and Altura B.M. Mechanisms of hydroxyl radical-induced contraction of rat aorta. Eur J Pharmacol 499 (2004) 171-178
21. Llorens S., Salazar F.J., and Nava E. Assessment of the nitric oxide system in the heart, aorta and kidney of aged Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens 23 (2005) 1507-1514
22. Ugochukwu N.H., and Cobourne M.K. Modification of renal oxidative stress and lipid peroxidation in streptozotocin-induced diabetic rats treated with extracts from Gongronema latifolium leaves. Clin Chim Acta 336 (2003) 73-81
23. Gao Q., Yang B., Ye Z.G., Wang J., Bruce I.C., and Xia Q. Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. Eur J Pharmacol 574 (2007) 179-184
24. Calles-Escandon J., and Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 22 (2001) 36-52
25. Guo X., Liu W.L., Chen L.W., and Guo Z.G. High glucose impairs endothelium-dependent relaxation in rabbit aorta. Acta Pharmacol Sin 21 (2000) 169-173
26. Li H., Xia N., Brausch I., Yao Y., and Forstermann U. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J Pharmacol Exp Ther 310 (2004) 926-932
27. Woodman O.L., and Chan E. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 31 (2004) 786-790
28. Uydes-Dogan B.S., Takir S., Ozdemir O., Kolak U., Topcu G., and Ulubelen A. The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. Vasc Pharmacol 43 (2005) 220-226
29. Marin J., and Rodriguez-Martinez M.A. Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol Ther 75 (1997) 111-134
30. Fujita S., Roerig D.L., Bosnjak Z.J., and Stowe D.F. Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts. Cardiovasc Res 38 (1998) 655-667
31. Li H., and Forstermann U. Nitric oxide in the pathogenesis of vascular disease. J Pathol 190 (2000) 244-254
32. Son S.M., Whalin M.K., Harrison D.G., Taylor W.R., and Griendling K.K. Oxidative stress and diabetic vascular complications. Curr Diab Rep 4 (2004) 247-252
33. Forstermann U., Boissel J.P., and Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 12 (1998) 773-790
34. Maritim A.C., Sanders R.A., and Watkins III J.B. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17 (2003) 24-38
35. Pieper G.M., Langenstroer P., and Siebeneich W. Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals. Cardiovasc Res 34 (1997) 145-156
36. Turko I.V., Marcondes S., and Murad F. Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase. Am J Physiol Heart Circ Physiol 281 (2001) H2289-H2294
37. Vega-Lopez S., Devaraj S., and Jialal I. Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease. J Invest Med 52 (2004) 24-32
38. Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 5 (2008) 338-349
39. Woodman O.L., Meeker W.F., Boujaoude M., and Vasorelaxant. antioxidant activity of flavonols and flavones: structure-activity relationships. J Cardiovasc Pharmacol 46 (2005) 302-309