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Volumn 185, Issue 1, 2015, Pages 230-239

Prostaglandin E2 receptor subtype 2 regulation of scavenger receptor CD36 modulates microglial Aβ42 phagocytosis

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CD36 ANTIGEN; PROSTAGLANDIN E RECEPTOR 2; SCAVENGER RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); NEUROTOXIN; PEPTIDE FRAGMENT; TOLL LIKE RECEPTOR;

EID: 84918800415     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.09.016     Document Type: Article
Times cited : (33)

References (69)
  • 1
    • 77951689435 scopus 로고    scopus 로고
    • Biomarkers of oxidative damage and inflammation in Alzheimer's disease
    • D. Galasko, and T.J. Montine Biomarkers of oxidative damage and inflammation in Alzheimer's disease Biomark Med 4 2010 27 36
    • (2010) Biomark Med , vol.4 , pp. 27-36
    • Galasko, D.1    Montine, T.J.2
  • 2
    • 84888317489 scopus 로고    scopus 로고
    • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • J.C. Lambert, C.A. Ibrahim-Verbaas, D. Harold, A.C. Naj, R. Sims, and C. Bellenguez Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease Nat Genet 45 2013 1452 1458
    • (2013) Nat Genet , vol.45 , pp. 1452-1458
    • Lambert, J.C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3    Naj, A.C.4    Sims, R.5    Bellenguez, C.6
  • 7
    • 84871855675 scopus 로고    scopus 로고
    • Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke
    • M.W. Sieber, N. Jaenisch, M. Brehm, M. Guenther, B. Linnartz-Gerlach, H. Neumann, O.W. Witte, and C. Frahm Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke PLoS One 8 2013 e52982
    • (2013) PLoS One , vol.8 , pp. 52982
    • Sieber, M.W.1    Jaenisch, N.2    Brehm, M.3    Guenther, M.4    Linnartz-Gerlach, B.5    Neumann, H.6    Witte, O.W.7    Frahm, C.8
  • 8
    • 84855221945 scopus 로고    scopus 로고
    • TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
    • H. Ito, and J.A. Hamerman TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells Eur J Immunol 42 2012 176 185
    • (2012) Eur J Immunol , vol.42 , pp. 176-185
    • Ito, H.1    Hamerman, J.A.2
  • 9
    • 84878135249 scopus 로고    scopus 로고
    • TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway
    • M. Sun, M. Zhu, K. Chen, X. Nie, Q. Deng, L.D. Hazlett, Y. Wu, M. Li, M. Wu, and X. Huang TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway Invest Ophthalmol Vis Sci 54 2013 3451 3462
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 3451-3462
    • Sun, M.1    Zhu, M.2    Chen, K.3    Nie, X.4    Deng, Q.5    Hazlett, L.D.6    Wu, Y.7    Li, M.8    Wu, M.9    Huang, X.10
  • 11
    • 77949892665 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and Alzheimer's disease: The epidemiological evidence
    • C.A. Szekely, and P.P. Zandi Non-steroidal anti-inflammatory drugs and Alzheimer's disease: the epidemiological evidence CNS Neurol Disord Drug Targets 9 2010 132 139
    • (2010) CNS Neurol Disord Drug Targets , vol.9 , pp. 132-139
    • Szekely, C.A.1    Zandi, P.P.2
  • 13
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial
    • Alzheimer's Disease Cooperative Study
    • P.S. Aisen, K.A. Schafer, M. Grundman, E. Pfeiffer, M. Sano, K.L. Davis, M.R. Farlow, S. Jin, R.G. Thomas, L.J. Thal Alzheimer's Disease Cooperative Study Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial JAMA 289 2003 2819 2826
    • (2003) JAMA , vol.289 , pp. 2819-2826
    • Aisen, P.S.1    Schafer, K.A.2    Grundman, M.3    Pfeiffer, E.4    Sano, M.5    Davis, K.L.6    Farlow, M.R.7    Jin, S.8    Thomas, R.G.9    Thal, L.J.10
  • 15
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • ADAPT Research Group
    • ADAPT Research Group B.K. Martin, C. Szekely, J. Brandt, S. Piantadosi, J.C. Breitner, S. Craft, D. Evans, R. Green, and M. Mullan Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib Arch Neurol 65 2008 896 905
    • (2008) Arch Neurol , vol.65 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9
  • 16
    • 79960997729 scopus 로고    scopus 로고
    • Soothing the inflamed brain: Effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology
    • J.J. Hoozemans, R. Veerhuis, J.M. Rozemuller, and P. Eikelenboom Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology CNS Neurol Disord Drug Targets 10 2011 57 67
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , pp. 57-67
    • Hoozemans, J.J.1    Veerhuis, R.2    Rozemuller, J.M.3    Eikelenboom, P.4
  • 17
    • 84861314593 scopus 로고    scopus 로고
    • Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
    • D. Jaturapatporn, M.G. Isaac, J. McCleery, and N. Tabet Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease Cochrane Database Syst Rev 2 2012 Cd006378
    • (2012) Cochrane Database Syst Rev , vol.2 , pp. 006378
    • Jaturapatporn, D.1    Isaac, M.G.2    McCleery, J.3    Tabet, N.4
  • 18
    • 77949502713 scopus 로고    scopus 로고
    • Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT
    • T.J. Montine, J.A. Sonnen, G. Milne, L.D. Baker, and J.C. Breitner Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT PLoS One 5 2010 e9340
    • (2010) PLoS One , vol.5 , pp. 9340
    • Montine, T.J.1    Sonnen, J.A.2    Milne, G.3    Baker, L.D.4    Breitner, J.C.5
  • 21
  • 23
    • 77949540912 scopus 로고    scopus 로고
    • Emerging roles of PGE2 receptors in models of neurological disease
    • K. Andreasson Emerging roles of PGE2 receptors in models of neurological disease Prostaglandins Other Lipid Mediat 91 2010 104 112
    • (2010) Prostaglandins Other Lipid Mediat , vol.91 , pp. 104-112
    • Andreasson, K.1
  • 26
    • 84877926316 scopus 로고    scopus 로고
    • Microsomal prostaglandin e synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model
    • Y. Akitake, Y. Nakatani, D. Kamei, M. Hosokawa, H. Akatsu, S. Uematsu, S. Akira, I. Kudo, S. Hara, and M. Takahashi Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model J Neurosci Res 91 2013 909 919
    • (2013) J Neurosci Res , vol.91 , pp. 909-919
    • Akitake, Y.1    Nakatani, Y.2    Kamei, D.3    Hosokawa, M.4    Akatsu, H.5    Uematsu, S.6    Akira, S.7    Kudo, I.8    Hara, S.9    Takahashi, M.10
  • 27
    • 27444436866 scopus 로고    scopus 로고
    • Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity
    • F.S. Shie, K.S. Montine, R.M. Breyer, and T.J. Montine Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity Glia 52 2005 70 77
    • (2005) Glia , vol.52 , pp. 70-77
    • Shie, F.S.1    Montine, K.S.2    Breyer, R.M.3    Montine, T.J.4
  • 28
    • 17144380506 scopus 로고    scopus 로고
    • Microglia lacking e Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity
    • F.S. Shie, R.M. Breyer, and T.J. Montine Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity Am J Pathol 166 2005 1163 1172
    • (2005) Am J Pathol , vol.166 , pp. 1163-1172
    • Shie, F.S.1    Breyer, R.M.2    Montine, T.J.3
  • 29
    • 73549084087 scopus 로고    scopus 로고
    • DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain
    • P.J. Cimino, I. Sokal, J. Leverenz, Y. Fukui, and T.J. Montine DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain Am J Pathol 175 2009 1622 1630
    • (2009) Am J Pathol , vol.175 , pp. 1622-1630
    • Cimino, P.J.1    Sokal, I.2    Leverenz, J.3    Fukui, Y.4    Montine, T.J.5
  • 30
    • 77954604328 scopus 로고    scopus 로고
    • Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow
    • C.D. Keene, R.C. Chang, A.H. Lopez-Yglesias, B.R. Shalloway, I. Sokal, X. Li, P.J. Reed, L.M. Keene, K.S. Montine, R.M. Breyer, J.K. Rockhill, and T.J. Montine Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow Am J Pathol 177 2010 346 354
    • (2010) Am J Pathol , vol.177 , pp. 346-354
    • Keene, C.D.1    Chang, R.C.2    Lopez-Yglesias, A.H.3    Shalloway, B.R.4    Sokal, I.5    Li, X.6    Reed, P.J.7    Keene, L.M.8    Montine, K.S.9    Breyer, R.M.10    Rockhill, J.K.11    Montine, T.J.12
  • 32
    • 67649216515 scopus 로고    scopus 로고
    • CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    • R.L. Silverstein, and M. Febbraio CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior Sci Signal 2 2009 re3
    • (2009) Sci Signal , vol.2 , pp. 3
    • Silverstein, R.L.1    Febbraio, M.2
  • 34
    • 0036141148 scopus 로고    scopus 로고
    • CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    • I.S. Coraci, J. Husemann, J.W. Berman, C. Hulette, J.H. Dufour, G.K. Campanella, A.D. Luster, S.C. Silverstein, and J.B. El-Khoury CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils Am J Pathol 160 2002 101 112
    • (2002) Am J Pathol , vol.160 , pp. 101-112
    • Coraci, I.S.1    Husemann, J.2    Berman, J.W.3    Hulette, C.4    Dufour, J.H.5    Campanella, G.K.6    Luster, A.D.7    Silverstein, S.C.8    El-Khoury, J.B.9
  • 38
    • 79851480221 scopus 로고    scopus 로고
    • Suppressed microglial e prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation
    • X. Li, E. Cudaback, C.D. Keene, R.M. Breyer, and T.J. Montine Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation Glia 59 2011 569 576
    • (2011) Glia , vol.59 , pp. 569-576
    • Li, X.1    Cudaback, E.2    Keene, C.D.3    Breyer, R.M.4    Montine, T.J.5
  • 39
    • 84863219648 scopus 로고    scopus 로고
    • Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor
    • X. Li, E. Cudaback, R.M. Breyer, K.S. Montine, C.D. Keene, and T.J. Montine Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor FASEB J 26 2012 3075 3083
    • (2012) FASEB J , vol.26 , pp. 3075-3083
    • Li, X.1    Cudaback, E.2    Breyer, R.M.3    Montine, K.S.4    Keene, C.D.5    Montine, T.J.6
  • 41
    • 0030871070 scopus 로고    scopus 로고
    • Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells
    • M. Kiriyama, F. Ushikubi, T. Kobayashi, M. Hirata, Y. Sugimoto, and S. Narumiya Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells Br J Pharmacol 122 1997 217 224
    • (1997) Br J Pharmacol , vol.122 , pp. 217-224
    • Kiriyama, M.1    Ushikubi, F.2    Kobayashi, T.3    Hirata, M.4    Sugimoto, Y.5    Narumiya, S.6
  • 42
    • 2942598274 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia
    • A.M. Pooler, A.A. Arjona, R.K. Lee, and R.J. Wurtman Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia Neurosci Lett 362 2004 127 130
    • (2004) Neurosci Lett , vol.362 , pp. 127-130
    • Pooler, A.M.1    Arjona, A.A.2    Lee, R.K.3    Wurtman, R.J.4
  • 43
    • 0033985188 scopus 로고    scopus 로고
    • Protein kinase C activation reduces microglial cyclic AMP response to prostaglandin E2 by interfering with EP2 receptors
    • M. Patrizio, M. Colucci, and G. Levi Protein kinase C activation reduces microglial cyclic AMP response to prostaglandin E2 by interfering with EP2 receptors J Neurochem 74 2000 400 405
    • (2000) J Neurochem , vol.74 , pp. 400-405
    • Patrizio, M.1    Colucci, M.2    Levi, G.3
  • 44
    • 80053415839 scopus 로고    scopus 로고
    • A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36
    • K. Wilkinson, J.D. Boyd, M. Glicksman, K.J. Moore, and J. El Khoury A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36 J Biol Chem 286 2011 34914 34922
    • (2011) J Biol Chem , vol.286 , pp. 34914-34922
    • Wilkinson, K.1    Boyd, J.D.2    Glicksman, M.3    Moore, K.J.4    El Khoury, J.5
  • 45
    • 84878420190 scopus 로고    scopus 로고
    • Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages
    • O. Kuda, T.A. Pietka, Z. Demianova, E. Kudova, J. Cvacka, J. Kopecky, and N.A. Abumrad Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages J Biol Chem 288 2013 15547 15555
    • (2013) J Biol Chem , vol.288 , pp. 15547-15555
    • Kuda, O.1    Pietka, T.A.2    Demianova, Z.3    Kudova, E.4    Cvacka, J.5    Kopecky, J.6    Abumrad, N.A.7
  • 46
    • 70349323417 scopus 로고    scopus 로고
    • CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation
    • E.G. Reed-Geaghan, J.C. Savage, A.G. Hise, and G.E. Landreth CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation J Neurosci 29 2009 11982 11992
    • (2009) J Neurosci , vol.29 , pp. 11982-11992
    • Reed-Geaghan, E.G.1    Savage, J.C.2    Hise, A.G.3    Landreth, G.E.4
  • 48
    • 37349069999 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line
    • M.L. Udan, D. Ajit, N.R. Crouse, and M.R. Nichols Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line J Neurochem 104 2008 524 533
    • (2008) J Neurochem , vol.104 , pp. 524-533
    • Udan, M.L.1    Ajit, D.2    Crouse, N.R.3    Nichols, M.R.4
  • 49
    • 22244456028 scopus 로고    scopus 로고
    • Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures
    • M. Lotz, S. Ebert, H. Esselmann, A.I. Iliev, M. Prinz, N. Wiazewicz, J. Wiltfang, J. Gerber, and R. Nau Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures J Neurochem 94 2005 289 298
    • (2005) J Neurochem , vol.94 , pp. 289-298
    • Lotz, M.1    Ebert, S.2    Esselmann, H.3    Iliev, A.I.4    Prinz, M.5    Wiazewicz, N.6    Wiltfang, J.7    Gerber, J.8    Nau, R.9
  • 50
    • 0028183018 scopus 로고
    • International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes
    • R.A. Coleman, W.L. Smith, and S. Narumiya International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes Pharmacol Rev 46 1994 205 229
    • (1994) Pharmacol Rev , vol.46 , pp. 205-229
    • Coleman, R.A.1    Smith, W.L.2    Narumiya, S.3
  • 51
    • 0022974379 scopus 로고
    • Effect of the specific thromboxane receptor blocking drug AH23848 in patients with angina pectoris
    • D.P. De Bono, P. Lumley, M. Been, R. Keery, S.E. Ince, and D.F. Woodings Effect of the specific thromboxane receptor blocking drug AH23848 in patients with angina pectoris Br Heart J 56 1986 509 517
    • (1986) Br Heart J , vol.56 , pp. 509-517
    • De Bono, D.P.1    Lumley, P.2    Been, M.3    Keery, R.4    Ince, S.E.5    Woodings, D.F.6
  • 52
    • 84879785100 scopus 로고    scopus 로고
    • Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection
    • J. Jiang, and R. Dingledine Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection Trends Pharmacol Sci 34 2013 413 423
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 413-423
    • Jiang, J.1    Dingledine, R.2
  • 53
    • 17444410014 scopus 로고    scopus 로고
    • Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons
    • F.S. Shie, K.S. Montine, R.M. Breyer, and T.J. Montine Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons Brain Pathol 15 2005 134 138
    • (2005) Brain Pathol , vol.15 , pp. 134-138
    • Shie, F.S.1    Montine, K.S.2    Breyer, R.M.3    Montine, T.J.4
  • 60
    • 67650957601 scopus 로고    scopus 로고
    • Regulation of TLR2 expression and function in human airway epithelial cells
    • T. Melkamu, D. Squillace, H. Kita, and S.M. O'Grady Regulation of TLR2 expression and function in human airway epithelial cells J Membr Biol 229 2009 101 113
    • (2009) J Membr Biol , vol.229 , pp. 101-113
    • Melkamu, T.1    Squillace, D.2    Kita, H.3    O'Grady, S.M.4
  • 63
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • S.E. Hickman, E.K. Allison, and J. El Khoury Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice J Neurosci 28 2008 8354 8360
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 64
    • 0034123963 scopus 로고    scopus 로고
    • Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma
    • J. Feng, J. Han, S.F. Pearce, R.L. Silverstein, A.M. Gotto Jr., D.P. Hajjar, and A.C. Nicholson Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma J Lipid Res 41 2000 688 696
    • (2000) J Lipid Res , vol.41 , pp. 688-696
    • Feng, J.1    Han, J.2    Pearce, S.F.3    Silverstein, R.L.4    Gotto, A.M.5    Hajjar, D.P.6    Nicholson, A.C.7
  • 66
    • 84858439865 scopus 로고    scopus 로고
    • Intracerebral microinjection of interleukin-4/interleukin-13 reduces beta-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice
    • K. Kawahara, M. Suenobu, A. Yoshida, K. Koga, A. Hyodo, H. Ohtsuka, A. Kuniyasu, N. Tamamaki, Y. Sugimoto, and H. Nakayama Intracerebral microinjection of interleukin-4/interleukin-13 reduces beta-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice Neuroscience 207 2012 243 260
    • (2012) Neuroscience , vol.207 , pp. 243-260
    • Kawahara, K.1    Suenobu, M.2    Yoshida, A.3    Koga, K.4    Hyodo, A.5    Ohtsuka, H.6    Kuniyasu, A.7    Tamamaki, N.8    Sugimoto, Y.9    Nakayama, H.10
  • 67
    • 84870226700 scopus 로고    scopus 로고
    • PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
    • M. Yamanaka, T. Ishikawa, A. Griep, D. Axt, M.P. Kummer, and M.T. Heneka PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice J Neurosci 32 2012 17321 17331
    • (2012) J Neurosci , vol.32 , pp. 17321-17331
    • Yamanaka, M.1    Ishikawa, T.2    Griep, A.3    Axt, D.4    Kummer, M.P.5    Heneka, M.T.6


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