A high content drug screen identifies ursolic acid as an inhibitor of amyloid β protein interactions with its receptor CD36

Journal of Biological Chemistry

Volumn 286, Issue 40, 2011, Pages 34914-34922

  Wilkinson, Kim ^a   Boyd, Justin D ^b   Glicksman, Marcie ^b   Moore, Kathryn J ^c   El Khoury, Joseph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CELL-BASED; COMPOUND LIBRARIES; DOSE-DEPENDENT MANNER; ELLIPTICINE; FOOD AND DRUG ADMINISTRATION; HIGH-CONTENT; HIGH-CONTENT SCREENING; MICROGLIA; MICROGLIAL CELLS; NATURALLY OCCURRING; NEURODEGENERATION; PLATE ASSAY; POTENTIAL INHIBITORS; PROINFLAMMATORY CYTOKINES; PROTEIN INTERACTION; REACTIVE OXYGEN SPECIES; RECEPTOR COMPLEX; REPRODUCIBILITIES; SIGNAL-TO-BACKGROUND RATIO; SMALL-MOLECULE LIBRARY; THERAPEUTIC AGENTS; THERAPEUTIC STRATEGY; TRITERPENOIDS; URSOLIC ACID;

DIMETHYL SULFOXIDE; GLYCOPROTEINS;

CELLS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CD36 ANTIGEN; CYTOKINE; ELLIPTICINE; HOMOMOSCHATOLINE; NEUROTOXIN; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; URSOLIC ACID; ZOXAZOLAMINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG IDENTIFICATION; DRUG SCREENING; INTRACELLULAR SIGNALING; MICROGLIA; MOLECULAR LIBRARY; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN INTERACTION; REPRODUCIBILITY;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIGENS, CD36; CHO CELLS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MICROGLIA; NEURODEGENERATIVE DISEASES; NEUROTOXINS; PLASMIDS; RECEPTORS, SCAVENGER; TRITERPENES;

EID: 80053415839     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.232116     Document Type: Article

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