Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening

Journal of Medicinal Chemistry

Volumn 57, Issue 23, 2014, Pages 9958-9970

  Yang, Bin ^a   Lamb, Michelle L ^a   Zhang, Tao ^a   Hennessy, Edward J ^a   Grewal, Gurmit ^a   Sha, Li ^a   Zambrowski, Mark ^a   Block, Michael H ^a   Dowling, James E ^a   Su, Nancy ^a   Wu, Jiaquan ^a   Deegan, Tracy ^a   Mikule, Keith ^a   Wang, Wenxian ^a   Kaspera, Rüdiger ^a   Chuaqui, Claudio ^a   Chen, Huawei ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CARBOXYLIC ACID; DIMETHYL SULFOXIDE; KINESIN INHIBITOR; MOLECULAR MOTOR; PHENYLALANINE; TRIETHYLAMINE; 5-METHYL-N-(1-OXO-1-(PYRROLIDIN-3-YLAMINO)-3-(6-(3-(TRIFLUOROMETHOXY)PHENYL)PYRIDIN-3-YL)PROPAN-2-YL)-4-PROPYLTHIOPHENE-2-CARBOXAMIDE; ALANINE; HUMAN SPLEEN, EMBRYO, AND TESTES EXPRESSED PROTEIN, HUMAN; KINESIN; PYRIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CENTROSOME; CROSS LINKING; CRYSTAL STRUCTURE; DEPROTECTION REACTION; DRUG POTENCY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; RACEMIZATION; SCREENING; SUZUKI REACTION; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; HELA CELL LINE; HUMAN; IC50; MOUSE; PROCEDURES; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALANINE; ANIMALS; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; KINESIN; MICE; PHENYLALANINE; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84918595366     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501179r     Document Type: Article

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