Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1

ACS Chemical Biology

Volumn 8, Issue 10, 2013, Pages 2201-2208

  Wu, Jiaquan ^a,b   Mikule, Keith ^a   Wang, Wenxian ^a   Su, Nancy ^a   Petteruti, Philip ^a   Gharahdaghi, Farzin ^a   Code, Erin ^a   Zhu, Xiahui ^a   Jacques, Kelly ^a   Lai, Zhongwu ^a   Yang, Bin ^a   Lamb, Michelle L ^a   Chuaqui, Claudio ^a   Keen, Nicholas ^a   Chen, Huawei ^a  

^a ASTRAZENECA   (United Kingdom)

^b Institute of Biomedical Research   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AZ 82; KINESIN; PROTEIN; PROTEIN INHIBITOR; PROTEIN KIFC1; UNCLASSIFIED DRUG; 5-METHYL-N-(1-OXO-1-(PYRROLIDIN-3-YLAMINO)-3-(6-(3-(TRIFLUOROMETHOXY)PHENYL)PYRIDIN-3-YL)PROPAN-2-YL)-4-PROPYLTHIOPHENE-2-CARBOXAMIDE; ALANINE; ENZYME INHIBITOR; HUMAN SPLEEN, EMBRYO, AND TESTES EXPRESSED PROTEIN, HUMAN; MOLECULAR LIBRARY; PYRIDINE DERIVATIVE;

ARTICLE; BREAST CANCER; CELL DEATH; CELL DIVISION; CENTROSOME; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYME ACTIVATION; HELA CELL LINE; MOLECULAR LIBRARY; PHARMACOLOGY;

ALANINE; DRUG DISCOVERY; ENZYME ACTIVATION; ENZYME INHIBITORS; HELA CELLS; HUMANS; KINESIN; MODELS, MOLECULAR; PYRIDINES; SMALL MOLECULE LIBRARIES;

EID: 84886577994     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400186w     Document Type: Article

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