Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes

Chemistry and Biology

Volumn 20, Issue 11, 2013, Pages 1399-1410

  Watts, Ciorsdaidh A ^a   Richards, Frances M ^a   Bender, Andreas ^a   Bond, Peter J ^a   Korb, Oliver ^b   Kern, Oliver ^c   Riddick, Michelle ^c   Owen, Paul ^d   Myers, Rebecca M ^a   Raff, Jordan ^e   Gergely, Fanni ^a   Jodrell, Duncan I ^a   Ley, Steven V ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE   (United Kingdom)

^c Babraham Research Campus   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CW 069; KINESIN; KINESIN INHIBITOR; MONASTROL; MOTOR PROTEIN HSET; UNCLASSIFIED DRUG; ANTHRANILIC ACID DERIVATIVE; CW069 COMPOUND; ENZYME INHIBITOR; PHENYLALANINE;

AMINO ACID SEQUENCE; ANAPHASE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CELL STRUCTURE; CENTROSOME; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; FIBROBLAST; FLUOROMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOSIS INHIBITION; MITOSIS SPINDLE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN UNFOLDING; ALLOSTERISM; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; MCF 7 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ALLOSTERIC REGULATION; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CENTROSOME; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HELA CELLS; HUMANS; KINESIN; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORTHO-AMINOBENZOATES; PHENYLALANINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888297107     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.09.012     Document Type: Article

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