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Volumn 1851, Issue 2, 2015, Pages 210-219

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

Author keywords

Ceramide; Diacylglycerol; Glucose tolerance; Liver; Sphingosine kinase 1; Triacylglycerol

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; GLUCOSE; SPHINGOSINE KINASE 1; TRIACYLGLYCEROL; FAT INTAKE; MESSENGER RNA; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE; SUGAR INTAKE;

EID: 84918566087     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2014.12.002     Document Type: Article
Times cited : (34)

References (80)
  • 1
    • 33645304589 scopus 로고    scopus 로고
    • Insulin resistance, the insulin resistance syndrome, and cardiovascular disease
    • G.M. Reaven Insulin resistance, the insulin resistance syndrome, and cardiovascular disease Panminerva Med. 47 4 2005 201 210
    • (2005) Panminerva Med. , vol.47 , Issue.4 , pp. 201-210
    • Reaven, G.M.1
  • 2
    • 4143151942 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes mellitus
    • ix
    • R.A. DeFronzo Pathogenesis of type 2 diabetes mellitus Med. Clin. North Am. 88 4 2004 787 835 ix
    • (2004) Med. Clin. North Am. , vol.88 , Issue.4 , pp. 787-835
    • Defronzo, R.A.1
  • 3
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • V.T. Samuel Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J. Biol. Chem. 279 31 2004 32345 32353
    • (2004) J. Biol. Chem. , vol.279 , Issue.31 , pp. 32345-32353
    • Samuel, V.T.1
  • 4
    • 65749091022 scopus 로고    scopus 로고
    • Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men
    • C. Brons Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men J. Physiol. (Lond.) 587 10 2009 2387 2397
    • (2009) J. Physiol. (Lond.) , vol.587 , Issue.10 , pp. 2387-2397
    • Brons, C.1
  • 5
    • 0028802645 scopus 로고
    • Loss of hepatic autoregulation after carbohydrate overfeeding in normal man
    • J.N. Clore, S.T. Helm, and W.G. Blackard Loss of hepatic autoregulation after carbohydrate overfeeding in normal man J. Clin. Investig. 96 4 1995 1967 1972
    • (1995) J. Clin. Investig. , vol.96 , Issue.4 , pp. 1967-1972
    • Clore, J.N.1    Helm, S.T.2    Blackard, W.G.3
  • 6
    • 33747075400 scopus 로고    scopus 로고
    • The effects of short-term overfeeding on insulin action in lean and reduced-obese individuals
    • M.A. Cornier, B.C. Bergman, and D.H. Bessesen The effects of short-term overfeeding on insulin action in lean and reduced-obese individuals Metab. Clin. Exp. 55 9 2006 1207 1214
    • (2006) Metab. Clin. Exp. , vol.55 , Issue.9 , pp. 1207-1214
    • Cornier, M.A.1    Bergman, B.C.2    Bessesen, D.H.3
  • 7
    • 0141532189 scopus 로고    scopus 로고
    • Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog
    • S.P. Kim Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog Diabetes 52 10 2003 2453 2460
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2453-2460
    • Kim, S.P.1
  • 8
    • 0026040907 scopus 로고
    • Development of muscle insulin resistance after liver insulin resistance in high-fat fed rats
    • E.W. Kraegen Development of muscle insulin resistance after liver insulin resistance in high-fat fed rats Diabetes 40 11 1991 1397 1403
    • (1991) Diabetes , vol.40 , Issue.11 , pp. 1397-1403
    • Kraegen, E.W.1
  • 9
    • 84878871217 scopus 로고    scopus 로고
    • Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
    • N. Turner Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding Diabetologia 56 7 2013 1638 1648
    • (2013) Diabetologia , vol.56 , Issue.7 , pp. 1638-1648
    • Turner, N.1
  • 10
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • E.L. Lim Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol Diabetologia 54 10 2011 2506 2514
    • (2011) Diabetologia , vol.54 , Issue.10 , pp. 2506-2514
    • Lim, E.L.1
  • 11
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • A. Seppala-Lindroos Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men J. Clin. Endocrinol. Metab. 87 7 2002 3023 3028
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.7 , pp. 3023-3028
    • Seppala-Lindroos, A.1
  • 12
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • K.F. Petersen Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes Diabetes 54 3 2005 603 608
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 603-608
    • Petersen, K.F.1
  • 13
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • V.T. Samuel, K.F. Petersen, and G.I. Shulman Lipid-induced insulin resistance: unravelling the mechanism Lancet 375 9733 2010 2267 2277
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 14
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • G. Marchesini Association of nonalcoholic fatty liver disease with insulin resistance Am. J. Med. 107 5 1999 450 455
    • (1999) Am. J. Med. , vol.107 , Issue.5 , pp. 450-455
    • Marchesini, G.1
  • 15
    • 84861647226 scopus 로고    scopus 로고
    • Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
    • (e2)
    • F. Magkos Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects Gastroenterology 142 7 2012 1444 1446 (e2)
    • (2012) Gastroenterology , vol.142 , Issue.7 , pp. 1444-1446
    • Magkos, F.1
  • 16
    • 84860482342 scopus 로고    scopus 로고
    • A ceramide-centric view of insulin resistance
    • J.A. Chavez, and S.A. Summers A ceramide-centric view of insulin resistance Cell Metab. 15 5 2012 585 594
    • (2012) Cell Metab. , vol.15 , Issue.5 , pp. 585-594
    • Chavez, J.A.1    Summers, S.A.2
  • 17
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • P. Angulo Nonalcoholic fatty liver disease N. Engl. J. Med. 346 16 2002 1221 1231
    • (2002) N. Engl. J. Med. , vol.346 , Issue.16 , pp. 1221-1231
    • Angulo, P.1
  • 19
    • 77951213051 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver
    • M. Bektas Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver J. Biol. Chem. 285 14 2010 10880 10889
    • (2010) J. Biol. Chem. , vol.285 , Issue.14 , pp. 10880-10889
    • Bektas, M.1
  • 20
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Y.A. Hannun, and L.M. Obeid Principles of bioactive lipid signalling: lessons from sphingolipids Nat. Rev. Mol. Cell Biol. 9 2 2008 139 150
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 21
    • 27744547965 scopus 로고    scopus 로고
    • SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
    • M. Maceyka SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism J. Biol. Chem. 280 44 2005 37118 37129
    • (2005) J. Biol. Chem. , vol.280 , Issue.44 , pp. 37118-37129
    • Maceyka, M.1
  • 22
    • 0035089286 scopus 로고    scopus 로고
    • Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
    • L.C. Edsall Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells J. Neurochem. 76 5 2001 1573 1584
    • (2001) J. Neurochem. , vol.76 , Issue.5 , pp. 1573-1584
    • Edsall, L.C.1
  • 23
    • 84870341562 scopus 로고    scopus 로고
    • Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high fat-fed mice
    • C.R. Bruce Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high fat-fed mice Diabetes 61 12 2012 3148 3155
    • (2012) Diabetes , vol.61 , Issue.12 , pp. 3148-3155
    • Bruce, C.R.1
  • 24
    • 33746840266 scopus 로고    scopus 로고
    • Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8
    • K. Kitajima Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8 Arterioscler. Thromb. Vasc. Biol. 26 8 2006 1852 1857
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , Issue.8 , pp. 1852-1857
    • Kitajima, K.1
  • 25
    • 84855161388 scopus 로고    scopus 로고
    • Adenovirus-associated virus vector-mediated gene transfer in hemophilia B
    • A.C. Nathwani Adenovirus-associated virus vector-mediated gene transfer in hemophilia B N. Engl. J. Med. 365 25 2011 2357 2365
    • (2011) N. Engl. J. Med. , vol.365 , Issue.25 , pp. 2357-2365
    • Nathwani, A.C.1
  • 26
    • 0027252060 scopus 로고
    • Hepatic glucose production during the labeled IVGTT: Estimation by deconvolution with a new minimal model
    • A. Caumo, and C. Cobelli Hepatic glucose production during the labeled IVGTT: estimation by deconvolution with a new minimal model Am. J. Physiol. 264 5 Pt 1 1993 E829 E841
    • (1993) Am. J. Physiol. , vol.264 , Issue.5 PART 1 , pp. 829-E841
    • Caumo, A.1    Cobelli, C.2
  • 27
    • 84897894674 scopus 로고    scopus 로고
    • The oral minimal model method
    • C. Cobelli The oral minimal model method Diabetes 63 4 2014 1203 1213
    • (2014) Diabetes , vol.63 , Issue.4 , pp. 1203-1213
    • Cobelli, C.1
  • 28
    • 84899686460 scopus 로고    scopus 로고
    • Advancing our understanding of the glucose system via modeling: A perspective
    • C. Cobelli Advancing our understanding of the glucose system via modeling: a perspective IEEE Trans. Biomed. Eng. 61 5 2014 1577 1592
    • (2014) IEEE Trans. Biomed. Eng. , vol.61 , Issue.5 , pp. 1577-1592
    • Cobelli, C.1
  • 29
    • 0030033930 scopus 로고    scopus 로고
    • 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects
    • 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects J. Clin. Invest. 97 1 1996 126 132
    • (1996) J. Clin. Invest. , vol.97 , Issue.1 , pp. 126-132
    • Taylor, R.1
  • 30
    • 77952094371 scopus 로고    scopus 로고
    • Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes
    • B. Vaitheesvaran Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes Metabolomics 6 2 2010 180 190
    • (2010) Metabolomics , vol.6 , Issue.2 , pp. 180-190
    • Vaitheesvaran, B.1
  • 31
    • 33845531143 scopus 로고    scopus 로고
    • Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse
    • J. Xu Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse Diabetes 55 12 2006 3372 3380
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3372-3380
    • Xu, J.1
  • 32
    • 84859129416 scopus 로고    scopus 로고
    • 13C]glucose
    • 13C]glucose PLoS ONE 7 3 2012 e34042
    • (2012) PLoS ONE , vol.7 , Issue.3 , pp. 34042
    • Delgado, T.C.1
  • 33
    • 0043210482 scopus 로고    scopus 로고
    • Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis
    • E.S. Jin Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis J. Biol. Chem. 278 31 2003 28427 28433
    • (2003) J. Biol. Chem. , vol.278 , Issue.31 , pp. 28427-28433
    • Jin, E.S.1
  • 34
    • 0022976955 scopus 로고
    • Glucose and fructose 6-phosphate cycle in humans
    • S. Karlander Glucose and fructose 6-phosphate cycle in humans Am. J. Physiol. 251 5 Pt 1 1986 E530 E536
    • (1986) Am. J. Physiol. , vol.251 , Issue.5 PART 1 , pp. 530-E536
    • Karlander, S.1
  • 35
    • 0006736211 scopus 로고
    • Increased activity of the glucose cycle in the liver: Early characteristic of type 2 diabetes
    • S. Efendic, A. Wajngot, and M. Vranic Increased activity of the glucose cycle in the liver: early characteristic of type 2 diabetes Proc. Natl. Acad. Sci. U. S. A. 82 9 1985 2965 2969
    • (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , Issue.9 , pp. 2965-2969
    • Efendic, S.1    Wajngot, A.2    Vranic, M.3
  • 36
    • 0021776279 scopus 로고
    • New probes to study insulin resistance in men; Futile cycle and glucose turnover
    • M. Vranic, A. Wajngot, and S. Efendic New probes to study insulin resistance in men; futile cycle and glucose turnover Adv. Exp. Med. Biol. 189 1985 227 245
    • (1985) Adv. Exp. Med. Biol. , vol.189 , pp. 227-245
    • Vranic, M.1    Wajngot, A.2    Efendic, S.3
  • 37
    • 0023928903 scopus 로고
    • Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity
    • S. Efendic, S. Karlander, and M. Vranic Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity J. Clin. Invest. 81 6 1988 1953 1961
    • (1988) J. Clin. Invest. , vol.81 , Issue.6 , pp. 1953-1961
    • Efendic, S.1    Karlander, S.2    Vranic, M.3
  • 38
    • 0033038503 scopus 로고    scopus 로고
    • Mass isotopomer distribution analysis at eight years: Theoretical, analytic, and experimental considerations
    • M.K. Hellerstein, and R.A. Neese Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations Am. J. Physiol. 276 6 Pt 1 1999 E1146 E1170
    • (1999) Am. J. Physiol. , vol.276 , Issue.6 PART 1 , pp. 1146-E1170
    • Hellerstein, M.K.1    Neese, R.A.2
  • 39
    • 0030017082 scopus 로고    scopus 로고
    • Contributions of gluconeogenesis to glucose production in the fasted state
    • B.R. Landau Contributions of gluconeogenesis to glucose production in the fasted state J. Clin. Invest. 98 2 1996 378 385
    • (1996) J. Clin. Invest. , vol.98 , Issue.2 , pp. 378-385
    • Landau, B.R.1
  • 40
    • 53349142351 scopus 로고    scopus 로고
    • Regulation of hepatic glucose production and the role of gluconeogenesis in humans: Is the rate of gluconeogenesis constant?
    • F.Q. Nuttall, A. Ngo, and M.C. Gannon Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant? Diabetes Metab. Res. Rev. 24 6 2008 438 458
    • (2008) Diabetes Metab. Res. Rev. , vol.24 , Issue.6 , pp. 438-458
    • Nuttall, F.Q.1    Ngo, A.2    Gannon, M.C.3
  • 41
    • 0035011295 scopus 로고    scopus 로고
    • Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus
    • G. Boden, X. Chen, and T.P. Stein Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus Am. J. Physiol. Endocrinol. Metab. 280 1 2001 E23 E30
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.280 , Issue.1 , pp. 23-E30
    • Boden, G.1    Chen, X.2    Stein, T.P.3
  • 42
    • 0028985271 scopus 로고
    • 2O for estimating rates of gluconeogenesis. Application to the fasted state
    • 2O for estimating rates of gluconeogenesis. Application to the fasted state J. Clin. Invest. 95 1 1995 172 178
    • (1995) J. Clin. Invest. , vol.95 , Issue.1 , pp. 172-178
    • Landau, B.R.1
  • 44
    • 79954522565 scopus 로고    scopus 로고
    • Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry
    • M.R. Antoniewicz, J.K. Kelleher, and G. Stephanopoulos Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry Anal. Chem. 83 8 2011 3211 3216
    • (2011) Anal. Chem. , vol.83 , Issue.8 , pp. 3211-3216
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 45
    • 33947580628 scopus 로고    scopus 로고
    • Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    • S.C. Burgess Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver Cell Metab. 5 4 2007 313 320
    • (2007) Cell Metab. , vol.5 , Issue.4 , pp. 313-320
    • Burgess, S.C.1
  • 46
    • 21044438041 scopus 로고    scopus 로고
    • Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
    • S.C. Burgess Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting Am. J. Physiol. Endocrinol. Metab. 289 1 2005 E53 E61
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289 , Issue.1 , pp. 53-E61
    • Burgess, S.C.1
  • 47
    • 0041864127 scopus 로고    scopus 로고
    • In vivo measurement of fluxes through metabolic pathways: The missing link in functional genomics and pharmaceutical research
    • M.K. Hellerstein In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research Annu. Rev. Nutr. 23 2003 379 402
    • (2003) Annu. Rev. Nutr. , vol.23 , pp. 379-402
    • Hellerstein, M.K.1
  • 48
    • 77954457487 scopus 로고    scopus 로고
    • Headspace analyses of acetone: A rapid method for measuring the 2H-labeling of water
    • V. Shah Headspace analyses of acetone: a rapid method for measuring the 2H-labeling of water Anal. Biochem. 404 2 2010 235 237
    • (2010) Anal. Biochem. , vol.404 , Issue.2 , pp. 235-237
    • Shah, V.1
  • 49
    • 0032079888 scopus 로고    scopus 로고
    • Assay of low deuterium enrichment of water by isotopic exchange with [U-13C3]acetone and gas chromatography-mass spectrometry
    • D. Yang Assay of low deuterium enrichment of water by isotopic exchange with [U-13C3]acetone and gas chromatography-mass spectrometry Anal. Biochem. 258 2 1998 315 321
    • (1998) Anal. Biochem. , vol.258 , Issue.2 , pp. 315-321
    • Yang, D.1
  • 50
    • 0141839083 scopus 로고    scopus 로고
    • 2O incorporation into the glycerol moiety and application of MIDA
    • 2O incorporation into the glycerol moiety and application of MIDA Am. J. Physiol. Endocrinol. Metab. 285 4 2003 E790 E803
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285 , Issue.4 , pp. 790-E803
    • Turner, S.M.1
  • 51
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipides from animal tissues J. Biol. Chem. 226 1 1957 497 509
    • (1957) J. Biol. Chem. , vol.226 , Issue.1 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 52
    • 11844294127 scopus 로고    scopus 로고
    • A rapid radioassay for sphingosine kinase
    • D.A. Vessey, M. Kelley, and J.S. Karliner A rapid radioassay for sphingosine kinase Anal. Biochem. 337 1 2005 136 142
    • (2005) Anal. Biochem. , vol.337 , Issue.1 , pp. 136-142
    • Vessey, D.A.1    Kelley, M.2    Karliner, J.S.3
  • 53
    • 0022970190 scopus 로고
    • Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells
    • J. Preiss Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells J. Biol. Chem. 261 19 1986 8597 8600
    • (1986) J. Biol. Chem. , vol.261 , Issue.19 , pp. 8597-8600
    • Preiss, J.1
  • 54
    • 84897954101 scopus 로고    scopus 로고
    • Sphingolipid homeostasis in the web of metabolic routes
    • A. Aguilera-Romero, C. Gehin, and H. Riezman Sphingolipid homeostasis in the web of metabolic routes Biochim. Biophys. Acta 1841 5 2014 647 656
    • (2014) Biochim. Biophys. Acta , vol.1841 , Issue.5 , pp. 647-656
    • Aguilera-Romero, A.1    Gehin, C.2    Riezman, H.3
  • 55
    • 33645278951 scopus 로고    scopus 로고
    • Sphingosine kinase: Biochemical and cellular regulation and role in disease
    • T.A. Taha, Y.A. Hannun, and L.M. Obeid Sphingosine kinase: biochemical and cellular regulation and role in disease J. Biochem. Mol. Biol. 39 2 2006 113 131
    • (2006) J. Biochem. Mol. Biol. , vol.39 , Issue.2 , pp. 113-131
    • Taha, T.A.1    Hannun, Y.A.2    Obeid, L.M.3
  • 56
    • 84866058762 scopus 로고    scopus 로고
    • Regulation of plasma ceramide levels with fatty acid oversupply: Evidence that the liver detects and secretes de novo synthesised ceramide
    • M.J. Watt Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide Diabetologia 55 10 2012 2741 2746
    • (2012) Diabetologia , vol.55 , Issue.10 , pp. 2741-2746
    • Watt, M.J.1
  • 57
    • 84873029099 scopus 로고    scopus 로고
    • Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance
    • J. Boon Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance Diabetes 62 2 2013 401 410
    • (2013) Diabetes , vol.62 , Issue.2 , pp. 401-410
    • Boon, J.1
  • 58
    • 77956826402 scopus 로고    scopus 로고
    • Blood sphingolipidomics in healthy humans: Impact of sample collection methodology
    • S.M. Hammad Blood sphingolipidomics in healthy humans: impact of sample collection methodology J. Lipid Res. 51 10 2010 3074 3087
    • (2010) J. Lipid Res. , vol.51 , Issue.10 , pp. 3074-3087
    • Hammad, S.M.1
  • 59
    • 84864365428 scopus 로고    scopus 로고
    • Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes
    • M.N. Barber Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes PLoS ONE 7 7 2012 e41456
    • (2012) PLoS ONE , vol.7 , Issue.7 , pp. 41456
    • Barber, M.N.1
  • 60
    • 0033544869 scopus 로고    scopus 로고
    • A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
    • N. Yahagi A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids J. Biol. Chem. 274 50 1999 35840 35844
    • (1999) J. Biol. Chem. , vol.274 , Issue.50 , pp. 35840-35844
    • Yahagi, N.1
  • 61
    • 0033544940 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
    • H. Shimano Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes J. Biol. Chem. 274 50 1999 35832 35839
    • (1999) J. Biol. Chem. , vol.274 , Issue.50 , pp. 35832-35839
    • Shimano, H.1
  • 62
    • 80053608473 scopus 로고    scopus 로고
    • Sphingolipid synthetic pathways are major regulators of lipid homeostasis
    • T.S. Worgall Sphingolipid synthetic pathways are major regulators of lipid homeostasis Adv. Exp. Med. Biol. 721 2011 139 148
    • (2011) Adv. Exp. Med. Biol. , vol.721 , pp. 139-148
    • Worgall, T.S.1
  • 63
    • 0037040241 scopus 로고    scopus 로고
    • Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism
    • T.S. Worgall Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism J. Biol. Chem. 277 6 2002 3878 3885
    • (2002) J. Biol. Chem. , vol.277 , Issue.6 , pp. 3878-3885
    • Worgall, T.S.1
  • 64
    • 2442419069 scopus 로고    scopus 로고
    • Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein
    • T.S. Worgall Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein Arterioscler. Thromb. Vasc. Biol. 24 5 2004 943 948
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , Issue.5 , pp. 943-948
    • Worgall, T.S.1
  • 65
    • 34248205140 scopus 로고    scopus 로고
    • Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
    • J.M. Aerts Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity Diabetes 56 5 2007 1341 1349
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1341-1349
    • Aerts, J.M.1
  • 66
    • 67650096801 scopus 로고    scopus 로고
    • Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
    • G. Yang Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome Am. J. Physiol. Endocrinol. Metab. 297 1 2009 E211 E224
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , Issue.1 , pp. 211-E224
    • Yang, G.1
  • 67
    • 72949117677 scopus 로고    scopus 로고
    • Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice
    • N. Bijl Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice Hepatology 50 5 2009 1431 1441
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1431-1441
    • Bijl, N.1
  • 68
    • 67651165606 scopus 로고    scopus 로고
    • Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice
    • H. Zhao Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice Hepatology 50 1 2009 85 93
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 85-93
    • Zhao, H.1
  • 69
    • 0028002620 scopus 로고
    • Signal transduction in vascular smooth muscle: Diacylglycerol second messengers and PKC action
    • M.W. Lee, and D.L. Severson Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action Am. J. Physiol. 267 3 Pt 1 1994 C659 C678
    • (1994) Am. J. Physiol. , vol.267 , Issue.3 PART 1 , pp. 659-C678
    • Lee, M.W.1    Severson, D.L.2
  • 70
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Y.A. Hannun, and L.M. Obeid The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind J. Biol. Chem. 277 29 2002 25847 25850
    • (2002) J. Biol. Chem. , vol.277 , Issue.29 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 71
    • 74249083210 scopus 로고    scopus 로고
    • S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species
    • N. Takuwa S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Cardiovasc. Res. 85 3 2010 484 493
    • (2010) Cardiovasc. Res. , vol.85 , Issue.3 , pp. 484-493
    • Takuwa, N.1
  • 72
    • 84860455885 scopus 로고    scopus 로고
    • The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    • R.V. Farese Jr. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance Cell Metab. 15 5 2012 570 573
    • (2012) Cell Metab. , vol.15 , Issue.5 , pp. 570-573
    • Farese, R.V.1
  • 73
    • 34347235098 scopus 로고    scopus 로고
    • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    • M. Monetti Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver Cell Metab. 6 1 2007 69 78
    • (2007) Cell Metab. , vol.6 , Issue.1 , pp. 69-78
    • Monetti, M.1
  • 74
    • 84870537777 scopus 로고    scopus 로고
    • Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
    • A.E. Mehran Hyperinsulinemia drives diet-induced obesity independently of brain insulin production Cell Metab. 16 6 2012 723 737
    • (2012) Cell Metab. , vol.16 , Issue.6 , pp. 723-737
    • Mehran, A.E.1
  • 75
    • 70350417158 scopus 로고    scopus 로고
    • Akt2 is required for hepatic lipid accumulation in models of insulin resistance
    • K.F. Leavens Akt2 is required for hepatic lipid accumulation in models of insulin resistance Cell Metab. 10 5 2009 405 418
    • (2009) Cell Metab. , vol.10 , Issue.5 , pp. 405-418
    • Leavens, K.F.1
  • 76
    • 0033826433 scopus 로고    scopus 로고
    • Physiological and nutritional regulation of enzymes of triacylglycerol synthesis
    • R.A. Coleman, T.M. Lewin, and D.M. Muoio Physiological and nutritional regulation of enzymes of triacylglycerol synthesis Annu. Rev. Nutr. 20 2000 77 103
    • (2000) Annu. Rev. Nutr. , vol.20 , pp. 77-103
    • Coleman, R.A.1    Lewin, T.M.2    Muoio, D.M.3
  • 77
    • 64949105862 scopus 로고    scopus 로고
    • Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat
    • T.C. Delgado Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat NMR Biomed. 22 3 2009 310 317
    • (2009) NMR Biomed. , vol.22 , Issue.3 , pp. 310-317
    • Delgado, T.C.1
  • 78
    • 67649518181 scopus 로고    scopus 로고
    • High fat feeding induces hepatic fatty acid elongation in mice
    • M.H. Oosterveer High fat feeding induces hepatic fatty acid elongation in mice PLoS ONE 4 6 2009 e6066
    • (2009) PLoS ONE , vol.4 , Issue.6 , pp. 6066
    • Oosterveer, M.H.1
  • 79
    • 84918577122 scopus 로고    scopus 로고
    • A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice
    • J.A. Duarte A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice J Lipid Res 55 12 2014 2541 2553
    • (2014) J Lipid Res , vol.55 , Issue.12 , pp. 2541-2553
    • Duarte, J.A.1
  • 80
    • 33847608656 scopus 로고    scopus 로고
    • Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice
    • M.M. Ma Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice Diabetologia 50 4 2007 891 900
    • (2007) Diabetologia , vol.50 , Issue.4 , pp. 891-900
    • Ma, M.M.1


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