Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry

Analytical Chemistry

Volumn 83, Issue 8, 2011, Pages 3211-3216

  Antoniewicz, Maciek R ^a,b   Kelleher, Joanne K ^a   Stephanopoulos, Gregory ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b University of Delaware   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY AND PRECISION; ANIMAL EXPERIMENTS; BOND CLEAVAGES; CALIBRATION CURVES; CARBON ATOMS; CARBON POSITION; CORRECTION FACTORS; DEUTERATED WATER; ELECTRON IMPACT; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCONEOGENESIS; GLUCOSE DERIVATIVES; HYDROGEN ATOMS; ISOPROPYLIDENE; ISOTOPOMER DISTRIBUTIONS; LEAST SQUARES REGRESSION;

ANIMAL CELL CULTURE; ATOMS; CELL CULTURE; DEUTERIUM; GAS CHROMATOGRAPHY; HYDROGEN; ISOMERS; MASS SPECTROMETRY;

GLUCOSE;

GLUCOSE; HYDROGEN;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; CHEMICAL STRUCTURE; MASS FRAGMENTOGRAPHY; MOUSE;

ANIMALS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; HYDROGEN; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE;

EID: 79954522565     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac200012p     Document Type: Article

References (23)

1. Kelleher, J. K. Metab. Eng. 2004, 6, 1-5
2. Antoniewicz, M. R.; Stephanopoulos, G.; Kelleher, J. K. Metabolomics 2006, 2, 41-52
3. Fernandez, C. A.; Des Rosiers, C. J. Biol. Chem. 1995, 270, 10037-10042
4. Landau, B. R.; Wahren, J.; Chandramouli, V.; Schumann, W. C.; Ekberg, K.; Kalhan, S. C. J. Clin. Invest. 1995, 95, 172-178
5. Malaisse, W. J.; Malaisse-Lagae, F.; Liemans, V.; Ottinger, R.; Willem, R. Mol. Cell. Biochem. 1990, 93, 153-165
6. Landau, B. R.; Wahren, J.; Chandramouli, V.; Schumann, W. C.; Ekberg, K.; Kalhan, S. C. J. Clin. Invest. 1996, 98, 378-385
7. Burgess, S. C.; Nuss, M.; Chandramouli, V.; Hardin, D. S.; Rice, M.; Landau, B. R.; Malloy, C. R.; Sherry, A. D. Anal. Biochem. 2003, 318, 321-324
8. Guo, Z. K.; Lee, W. N.; Katz, J.; Bergner, A. E. Anal. Biochem. 1992, 204, 273-282
9. Desage, M.; Guilluy, R.; Brazier, J. L.; Riou, J. P.; Beylot, M.; Normand, S.; Vidal, H. Biomed. Environ. Mass Spectrom. 1989, 18, 1010-1015
10. Beylot, M.; Previs, S. F.; David, F.; Brunengraber, H. Anal. Biochem. 1993, 212, 526-531
11. Price, N. P. Anal. Chem. 2004, 76, 6566-6574
12. Antoniewicz, M. R.; Kelleher, J. K.; Stephanopoulos, G. Anal. Chem. 2007, 79, 7554-7559
13. Biemann, K.; de Jongh, D. C.; Schnoes, H. K. Am. J. Chem. Soc. 1963, 85, 1763-1770
14. Laine, R. A.; Sweeley, C. C. Anal. Biochem. 1971, 43, 533-538
15. Szafranek, J.; Pfaffenberger, C. D.; Horning, E. C. Carbohydr. Res. 1974, 38, 97-105
16. Hachey, D. L.; Parsons, W. R.; McKay, S.; Haymond, M. W. Anal. Chem. 1999, 71, 4734-4739
17. Ciucanu, I.; Kerek, F. Carbohydr. Res. 1984, 131, 209-217
18. Ciucanu, I.; Costello, C. E. J. Am. Chem. Soc. 2003, 125, 16213-16219
19. Crown, S. B.; Indurthi, D. C.; Ahn, W. S.; Choi, J.; Papoutsakis, E. T.; Antoniewicz, M. R. Biotechnol. J. 2011, 6, 300-305
20. Choi, J.; Antoniewicz, M. R. Metab. Eng. 2011, 13, 225-233
21. Young, J. D.; Walther, J. L.; Antoniewicz, M. R.; Yoo, H.; Stephanopoulos, G. Biotechnol. Bioeng. 2008, 99, 686-699
22. Fagerquist, C. K.; Hellerstein, M. K.; Faubert, D.; Bertrand, M. J. J. Am. Soc. Mass Spectrom. 2001, 12, 754-761
23. Antoniewicz, M. R.; Kelleher, J. K.; Stephanopoulos, G. Metab. Eng. 2006, 8, 324-337