Mass isotopomer distribution analysis at eight years: Theoretical, analytic, and experimental considerations

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 6 39-6, 1999, Pages

  Hellerstein, Marc K ^a,b,c   Neese, Richard A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTIC METHOD; ARTICLE; BIOSYNTHESIS; MASS SPECTROMETRY; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEASUREMENT; POLYMERIZATION; PRIORITY JOURNAL; TECHNIQUE;

EID: 0033038503     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.6.e1146     Document Type: Article

References (40)

1. Aarsland, A., D. Chinkes, and R. R. Wolfe. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J. Clin. Invest. 98: 2008-2017, 1996.
2. Benyon, J. H. Mass Spectrometry and its Application to Organic Chemistry. New York: Elsevier, 1960.
3. Bergner, E. A., and W.-N. P. Lee. Testing gas chromatographic/ mass spectrometric systems for linearity of response. J. Mass Spectrom. 30: 778-780, 1995.
4. 2O to quantitate cholesterol and fatty acid synthesis in tumor-bearing rats. FASEB J. 7: A289, 1993.
5. Chinkes, D. L., A. Aarsland, J. Rosenblatt, and R. R. Wolfe. Comparison of mass isotopomer dilution methods used to calculate VLDL production in vivo. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E373-E383, 1996.
6. Deines, P. The isotopic composition of reduced organic carbon. In: Handbook of Environmental Isotope Geochemistry. The Terrestrial Environment, edited by P. Fritz and J. C. Fontes. Amsterdam: Elsevier, 1980, vol. 1, chapt. 9.
7. Dekker, E., M. K. Hellerstein, J. A. Romijn, R. A. Neese, N. Peshu, E. Endert, K. Marsh, and H. P. Sauerwein. Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production. J. Clin. Endocrinol. Metab. 82: 2514-2521, 1997.
8. Des Rosiers, C., F. David, M. Garneau, and H. Brunengraber. Nonhomogenous labeling of liver mitochondrial acetyl-CoA. J. Biol. Chem. 266: 1574-1578, 1991.
9. Dietschy, J. M., and M. S. Brown. Effect of alterations of the specific activity of intracellular acetyl-CoA pool on apparent rates of hepatic cholesterogenesis. J. Lipid Res. 15: 508-516, 1974.
10. Fagerquist, C., and J.-M. Schwarz. Gas-phase acid-base chemistry and its effects on mass isotopomer abundance measurements of biomolecular ions. J. Mass Spectrom. 33: 144-153, 1998.
11. Fagerquist, C. K., R. A. Neese, and M. K. Hellerstein. Molecular ion fragmentation and its effects on mass isotopomer abundances of fatty acid methyl esters ionized by electron impact. J. Am. Soc. Mass Spectrom. 10: 430-439, 1999.
12. Faix, D., R. A. Neese, C. Kletke, S. Walden, D. Cesar, M. Coutlangus, C. H. L. Shackleton, and M. K. Hellerstein. Quantification of periodicities in menstrual and diurnal rates of cholesterol and fat synthesis in humans. J. Lipid Res. 34: 2063-2075, 1993.
13. 1 isotopomer frequencies in a secreted polymer. J. Biol. Chem. 266: 10920-10924, 1991.
14. Hellerstein, M. K., M. Christiansen, S. Kaempfer, C. Kletke, K. Wu, J. S. Reid, N. S. Hellerstein, and C. H. L. Shackleton. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J. Clin. Invest. 87: 1841-1852, 1991.
15. Hellerstein, M. K., and R. Neese. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E988-E1001, 1992.
16. Hellerstein, M. K., J.-M. Schwarz, and R. A. Neese. Regulation of hepatic de novo lipogenesis in humans. Annu. Rev. Nutr. 16: 523-557, 1996.
17. Hellerstein, M. K., K. Wu, S. Kaempfer, C. Kletke, and C. H. L. Shackleton. Sampling the lipogenic hepatic acetyl-CoA pool in vivo in the rat. Comparison of xenobiotic probe to values predicted from isotopomeric distribution in circulating lipids and measurement of lipogenesis and acetyl-CoA dilution. J. Biol. Chem. 266: 10912-10919, 1991.
18. Hentze, M. W. Determinants and regulation of cytoplasmic mRNA stability in eucaryotic cells. Biochim. Biophys. Acta 1090: 281-292, 1991.
19. 12C atoms in the pathway of gluconeogenesis in vivo (Abstract). Federation Proc. 41: 109, 1982.
20. Kelleher, J. K., A. T. Kharroubi, T. A. Aldaghlas, I. B. Shambat, K. A. Kennedy, A. L. Holleran, and T. M. Masterson. Isotopomer spectral analysis of cholesterol synthesis: applications in human hepatoma cells. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E384-E395, 1994.
21. Kelleher, J. K., and T. M. Masterson. Model equations for condensation biosynthesis using stable isotopes and radioisotopes. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E118-E125, 1992.
22. Lee, W. N. P., E. A. Bergner, and Z. K. Guo. Mass isotopomer pattern and precursor-product relationship. Biol. Mass. Spectrom. 21: 114-122, 1992.
23. Mills, M., J. Chen, R. Neese, M. Hellerstein, and J.-M. Schwarz. Mass isotopomer distribution analysis (MIDA) for measurement of gluconeogenesis (GNG) under conditions of hyperglycemia in streptozotocin (stz) diabetic rats (Abstract). Diabetes 47, Suppl. 1: A287, 1998.
24. Mook, W. G., and P. M. Grootes. The measuring procedure and corrections for the high-precision mass-spectrometric analysis of isotopic abundance ratios, especially referring to carbon, oxygen and nitrogen. Int. J. Mass Spectrom. Ion Phys. 12: 273-298, 1973.
25. Neese, R. A., D. Faix, C. Kletke, K. Wu, A. C. Wang, C. H. L. Shackleton, and M. K. Hellerstein. Measurement of endogenous synthesis of plasma cholesterol in rats and humans using MIDA. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E136-E147, 1993.
26. Neese, R. A., D. Faix, J.-M. Schwarz, S. M. Turner, D. Vu, and M. K. Hellerstein. Measurement of gluconeogenesis and rate of appearance of intrahepatic triose-phosphate and its regulation by substrates by mass isotopomer distribution analysis (MIDA). Testing of assumptions and potential problems. J. Biol. Chem. 270: 14452-14463, 1995.
27. Neese, R. A., and M. K. Hellerstein. Appendix. Calculations for gluconeogenesis by MIDA. J. Biol. Chem. 270: 14464-14466, 1995.
28. Papageorgopoulos, C., K. Caldwell, C. H. L. Shackleton, H. Schweingruber, and M. K. Hellerstein. Measuring of protein synthesis by mass isotopomer distribution analysis (MIDA). Anal. Biochem. 267: 1-16, 1999.
29. Park, O.-J., D. Cesar, D. Faix, K. Wu, C. H. L. Shackleton, and M. K. Hellerstein. Mechanisms of fructose-induced hypertriglyceridemia in the rat: activation of hepatic pyruvate dehydrogenase (PDH) through inhibition of PDH kinase. Biochem. J. 282: 753-757, 1992.
30. Patterson, B. W., and R. R. Wolfe. Concentration dependance of methyl-palmitate isotope ratios by electron impact ionization gas chromatography/mass spectrometry. Biol. Mass Spectrom. 22: 481-486, 1993.
31. 13C]glycerol and mass isotopomer distribution analysis of glucose. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E516-E523, 1995.
32. Previs, S. F., C. A. Fernandez, D. Yang, M. V. Soloviev, D. France, and H. Brunengraber. Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis substrate cycling between glycerol and triose phosphates in liver. J. Biol. Chem. 270: 19806-19815, 1995.
33. Sackett, W. M. Stable carbon isotope studies on organic matter in the marine environment. In: Handbook of Environmental Isotope Geochemistry. The Terrestrial Environment, edited by P. Fritz and J. C. Fontes. Amsterdam: Elsevier, 1980, vol. 1, chapt. 4, p. 141-178.
34. 14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis. J. Biol. Chem. 266: 6985-6990, 1991.
35. Seeman, J. I., H. V. Secor, R. Disselkamp, and E. R. Bernstein. Conformational analysis through selective isotopic substitution: supersonic jet spectroscopic determination of the minimum energy conformation of o-xylene. J. Chem. Soc. Chem. Commun. 1992: 713-714, 1992.
36. Siler, S. Q., R. A. Neese, M. P. Christiansen, and M. K. Hellerstein. The inhibition of gluconeogenesis following alcohol in humans. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E897-E907, 1998.
37. Srere, P. Complexities of metabolic regulation. Trends Biochem. Sci. 19: 519-520, 1994.
38. Waterlow, J. C., P. J. Garlick, and D. J. Millward (Editors). Protein Turnover in Mammalian Tissues and in the Whole Body. Amsterdam: North Holland, 1978.
39. Wolfe, R. R. Tracers in Metabolic Research. Radio-Isotope and Stable Isotope/Mass Spectrometric Methods. New York: Liss, 1984, p. 119-144.
40. Zilversmit, D. B. The design and analysis of isotope experiments. Am. J. Med. 29: 832-848, 1960.