Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 307, Issue 12, 2014, Pages L987-L997

  Wu, Feng ^a   Szczepaniak, William S ^a   Shiva, Sruti ^a,b   Liu, Huanbo ^a   Wang, Yinna ^b   Wang, Ling ^b   Wang, Ying ^a   Kelley, Eric E ^a,b   Chen, Alex F ^a,b   Gladwin, Mark T ^a,b   McVerry, Bryan J ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Acute respiratory distress syndrome; Endothelial barrier function; Endothelial nitric oxide synthase uncoupling; NADPH oxidase; Nitric oxide

Indexed keywords

BIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; SUPEROXIDE; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN; CARRIER PROTEIN; CYBB PROTEIN, HUMAN; CYBB PROTEIN, MOUSE; GLUTATHIONE; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE, ESCHERICHIA COLI 0111 B4; MEMBRANE PROTEIN; NITRIC OXIDE; NOS3 PROTEIN, MOUSE; NOSIP PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ACUTE LUNG INJURY; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LUNG EDEMA; LUNG ENDOTHELIUM; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN INTERACTION; PROTEIN PROCESSING; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYMOLOGY; GENETICS; HUMAN; KNOCKOUT MOUSE; LUNG; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; VASCULARIZATION;

ACUTE LUNG INJURY; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; ENDOTHELIAL CELLS; GLUTATHIONE; HUMANS; LIPOPOLYSACCHARIDES; LUNG; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 84918546420     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00063.2014     Document Type: Article

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