Febuxostat inhibition of endothelial-bound XO: Implications for targeting vascular ROS production

Free Radical Biology and Medicine

Volumn 51, Issue 1, 2011, Pages 179-184

  Malik, Umair Z ^a   Hundley, Nicholas J ^b   Romero, Guillermo ^b   Radi, Rafael ^c   Freeman, Bruce A ^b   Tarpey, Margaret M ^b,d   Kelley, Eric E ^b  

^a AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Allopurinol; Endothelial cells; Febuxostat; Free radicals; Inflammation; Oxypurinol; Reactive oxygen species; Uloric; Xanthine oxidase; Xanthine oxidase inhibitors

Indexed keywords

ALLOPURINOL; FEBUXOSTAT; GLYCOSAMINOGLYCAN; REACTIVE OXYGEN METABOLITE; URIC ACID; XANTHINE OXIDASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COW; DRUG EFFECT; DRUG TARGETING; DRUG TOLERABILITY; ENDOTHELIUM CELL; ENZYME BINDING; ENZYME IMMOBILIZATION; ENZYME INHIBITION; FEMALE; IC 50; KINETICS; NONHUMAN; PRIORITY JOURNAL;

ALLOPURINOL; ANIMALS; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GLYCOSAMINOGLYCANS; KINETICS; OXYPURINOL; REACTIVE OXYGEN SPECIES; THIAZOLES; XANTHINE OXIDASE;

EID: 79957951218     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.04.004     Document Type: Article

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