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Volumn 450-451, Issue , 2014, Pages 64-70

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

Author keywords

DeISGylating activity; DUB activity; ISG15; MERS CoV; PLpro; Ubiquitin

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS PAPAIN LIKE PROTEASES; NONSTRUCTURAL PROTEIN 3; PAPAIN; RANTES; UNCLASSIFIED DRUG;

EID: 84890863276     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2013.11.040     Document Type: Article
Times cited : (188)

References (41)
  • 2
    • 29744455503 scopus 로고    scopus 로고
    • The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity
    • Barretto N., Jukneliene D., Ratia K., Chen Z., Mesecar A.D., Baker S.C. The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J. Virol. 2005, 79(24):15189-15198.
    • (2005) J. Virol. , vol.79 , Issue.24 , pp. 15189-15198
    • Barretto, N.1    Jukneliene, D.2    Ratia, K.3    Chen, Z.4    Mesecar, A.D.5    Baker, S.C.6
  • 3
    • 77950806384 scopus 로고    scopus 로고
    • Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases
    • Clementz M.A., Chen Z., Banach B.S., Wang Y., Sun L., Ratia K., et al. Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. J. Virol. 2010, 84(9):4619-4629.
    • (2010) J. Virol. , vol.84 , Issue.9 , pp. 4619-4629
    • Clementz, M.A.1    Chen, Z.2    Banach, B.S.3    Wang, Y.4    Sun, L.5    Ratia, K.6
  • 4
    • 34249790592 scopus 로고    scopus 로고
    • Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63
    • Chen Z., Wang Y., Ratia K., Mesecar A.D., Wilkinson K.D., Baker S.C. Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. J. Virol. 2007, 81(11):6007-6018.
    • (2007) J. Virol. , vol.81 , Issue.11 , pp. 6007-6018
    • Chen, Z.1    Wang, Y.2    Ratia, K.3    Mesecar, A.D.4    Wilkinson, K.D.5    Baker, S.C.6
  • 5
    • 84882614929 scopus 로고    scopus 로고
    • Clinical features and virological analysis of a case of middle east respiratory syndrome coronavirus infection
    • Drosten C., Seilmaier M., Corman V.M., Hartmann W., Scheible G., Sack S., et al. Clinical features and virological analysis of a case of middle east respiratory syndrome coronavirus infection. Lancet Infect. Dis. 2013, 13(9):745-751.
    • (2013) Lancet Infect. Dis. , vol.13 , Issue.9 , pp. 745-751
    • Drosten, C.1    Seilmaier, M.2    Corman, V.M.3    Hartmann, W.4    Scheible, G.5    Sack, S.6
  • 6
    • 36148979683 scopus 로고    scopus 로고
    • Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus
    • Devaraj S.G., Wang N., Chen Z., Chen Z., Tseng M., Barretto N., et al. Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J. Biol. Chem. 2007, 282(44):32208-32221.
    • (2007) J. Biol. Chem. , vol.282 , Issue.44 , pp. 32208-32221
    • Devaraj, S.G.1    Wang, N.2    Chen, Z.3    Chen, Z.4    Tseng, M.5    Barretto, N.6
  • 7
    • 67449088510 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling
    • Frieman M., Ratia K., Johnston R.E., Mesecar A.D., Baric R.S. Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling. J. Virol. 2009, 83(13):6689-6705.
    • (2009) J. Virol. , vol.83 , Issue.13 , pp. 6689-6705
    • Frieman, M.1    Ratia, K.2    Johnston, R.E.3    Mesecar, A.D.4    Baric, R.S.5
  • 8
    • 36749007273 scopus 로고    scopus 로고
    • Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses
    • Frias-Staheli N., Giannakopoulos N.V., Kikkert M., Taylor S.L., Bridgen A., Paragas J., et al. Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell Host Microbe 2007, 2(6):404-416.
    • (2007) Cell Host Microbe , vol.2 , Issue.6 , pp. 404-416
    • Frias-Staheli, N.1    Giannakopoulos, N.V.2    Kikkert, M.3    Taylor, S.L.4    Bridgen, A.5    Paragas, J.6
  • 9
    • 84880053841 scopus 로고    scopus 로고
    • Clinical features and viral diagnosis of two cases of infection with middle east respiratory syndrome coronavirus: a report of nosocomial transmission
    • Guery B., Poissy J., El Mansouf L., Sejourne C., Ettahar N., Lemaire X., et al. Clinical features and viral diagnosis of two cases of infection with middle east respiratory syndrome coronavirus: a report of nosocomial transmission. Lancet 2013, 381(9885):2265-2272.
    • (2013) Lancet , vol.381 , Issue.9885 , pp. 2265-2272
    • Guery, B.1    Poissy, J.2    El Mansouf, L.3    Sejourne, C.4    Ettahar, N.5    Lemaire, X.6
  • 10
    • 84879571351 scopus 로고    scopus 로고
    • Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus
    • 10.1128/mBio.00165-13
    • Josset L., Menachery V.D., Gralinski L.E., Agnihothram S., Sova P., Carter V.S., et al. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio 2013, 4(3), 10.1128/mBio.00165-13.
    • (2013) mBio , vol.4 , Issue.3
    • Josset, L.1    Menachery, V.D.2    Gralinski, L.E.3    Agnihothram, S.4    Sova, P.5    Carter, V.S.6
  • 11
    • 84886921982 scopus 로고    scopus 로고
    • Assessing activity and inhibition of MERS-CoV papain-like and 3C-like proteases using luciferase-based biosensors
    • Kilianski A., Mielech A., Deng X., Baker S.C. Assessing activity and inhibition of MERS-CoV papain-like and 3C-like proteases using luciferase-based biosensors. J. Virol. 2013, 87(21):11955-11962.
    • (2013) J. Virol. , vol.87 , Issue.21 , pp. 11955-11962
    • Kilianski, A.1    Mielech, A.2    Deng, X.3    Baker, S.C.4
  • 12
    • 33846104528 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists
    • Kopecky-Bromberg S., Martinez-Sobrido L., Frieman M., Baric R., Palese P. Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists. J. Virol. 2007, 81(2):548-557.
    • (2007) J. Virol. , vol.81 , Issue.2 , pp. 548-557
    • Kopecky-Bromberg, S.1    Martinez-Sobrido, L.2    Frieman, M.3    Baric, R.4    Palese, P.5
  • 13
    • 70350768988 scopus 로고    scopus 로고
    • A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein
    • Kamitani W., Huang C., Narayanan K., Lokugamage K., Makino S. A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein. Nat. Struct. Mol. Biol. 2009, 16(11):1134-1140.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , Issue.11 , pp. 1134-1140
    • Kamitani, W.1    Huang, C.2    Narayanan, K.3    Lokugamage, K.4    Makino, S.5
  • 14
    • 25444531712 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus-like virus in chinese horseshoe bats
    • Lau S.K., Woo P.C., Li K.S., Huang Y., Tsoi H.W., Wong B.H., et al. Severe acute respiratory syndrome coronavirus-like virus in chinese horseshoe bats. Proc. Natl. Acad. Sci. USA 2005, 102(39):14040-14045.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.39 , pp. 14040-14045
    • Lau, S.K.1    Woo, P.C.2    Li, K.S.3    Huang, Y.4    Tsoi, H.W.5    Wong, B.H.6
  • 15
    • 29744463886 scopus 로고    scopus 로고
    • The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme
    • Lindner H.A., Fotouhi-Ardakani N., Lytvyn V., Lachance P., Sulea T., Menard R. The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme. J. Virol. 2005, 79(24):15199-15208.
    • (2005) J. Virol. , vol.79 , Issue.24 , pp. 15199-15208
    • Lindner, H.A.1    Fotouhi-Ardakani, N.2    Lytvyn, V.3    Lachance, P.4    Sulea, T.5    Menard, R.6
  • 16
    • 34548651826 scopus 로고    scopus 로고
    • Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease
    • Lindner H.A., Lytvyn V., Qi H., Lachance P., Ziomek E., Menard R. Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease. Arch. Biochem. Biophys. 2007, 466(1):8-14.
    • (2007) Arch. Biochem. Biophys. , vol.466 , Issue.1 , pp. 8-14
    • Lindner, H.A.1    Lytvyn, V.2    Qi, H.3    Lachance, P.4    Ziomek, E.5    Menard, R.6
  • 18
    • 84886298565 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist
    • (Epub ahead of print)
    • Niemeyer D., Zillinger T., Muth D., Zielecki F., Horvath G., Suliman T., et al. Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist. J. Virol. 2013, (Epub ahead of print). 10.1128/JVI.01845-13.
    • (2013) J. Virol.
    • Niemeyer, D.1    Zillinger, T.2    Muth, D.3    Zielecki, F.4    Horvath, G.5    Suliman, T.6
  • 19
    • 67349158649 scopus 로고    scopus 로고
    • Coronaviruses post-SARS: update on replication and pathogenesis
    • Perlman S., Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat. Rev. Microbiol. 2009, 7(6):439-450.
    • (2009) Nat. Rev. Microbiol. , vol.7 , Issue.6 , pp. 439-450
    • Perlman, S.1    Netland, J.2
  • 20
    • 84880983559 scopus 로고    scopus 로고
    • Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus
    • Qian Z., Travanty E., Oko L., Edeen K., Berglund A., Wang J., et al. Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus. Am. J. Respir. Cell Mol. Biol. 2013, 48(6):742-748.
    • (2013) Am. J. Respir. Cell Mol. Biol. , vol.48 , Issue.6 , pp. 742-748
    • Qian, Z.1    Travanty, E.2    Oko, L.3    Edeen, K.4    Berglund, A.5    Wang, J.6
  • 21
    • 84884377173 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
    • Reusken C.B., Haagmans B.L., Müller M.A., Gutierrez C., Godeke G., Meyer B., et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect. Dis. 2013, 13(10):859-866.
    • (2013) Lancet Infect. Dis. , vol.13 , Issue.10 , pp. 859-866
    • Reusken, C.B.1    Haagmans, B.L.2    Müller, M.A.3    Gutierrez, C.4    Godeke, G.5    Meyer, B.6
  • 22
    • 34447273596 scopus 로고    scopus 로고
    • Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice
    • Rockx B., Sheahan T., Donaldson E., Harkema J., Sims A., Heise M., et al. Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. J. Virol. 2007, 81(14):7410-7423.
    • (2007) J. Virol. , vol.81 , Issue.14 , pp. 7410-7423
    • Rockx, B.1    Sheahan, T.2    Donaldson, E.3    Harkema, J.4    Sims, A.5    Heise, M.6
  • 23
    • 33645822092 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme
    • Ratia K., Saikatendu K.S., Santarsiero B.D., Barretto N., Baker S.C., Stevens R.C., et al. Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proc. Natl. Acad. Sci. USA 2006, 103(15):5717-5722.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.15 , pp. 5717-5722
    • Ratia, K.1    Saikatendu, K.S.2    Santarsiero, B.D.3    Barretto, N.4    Baker, S.C.5    Stevens, R.C.6
  • 24
    • 26844503987 scopus 로고    scopus 로고
    • The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
    • Rothenfusser S., Goutagny N., DiPerna G., Gong M., Monks B.G., Schoenemeyer A., et al. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J. Immunol. 2005, 175(8):5260-5268.
    • (2005) J. Immunol. , vol.175 , Issue.8 , pp. 5260-5268
    • Rothenfusser, S.1    Goutagny, N.2    DiPerna, G.3    Gong, M.4    Monks, B.G.5    Schoenemeyer, A.6
  • 25
    • 55849113043 scopus 로고    scopus 로고
    • A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
    • Ratia K., Pegan S., Takayama J., Sleeman K., Coughlin M., Baliji S., et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc. Natl. Acad. Sci. USA 2008, 105(42):16119-16124.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.42 , pp. 16119-16124
    • Ratia, K.1    Pegan, S.2    Takayama, J.3    Sleeman, K.4    Coughlin, M.5    Baliji, S.6
  • 26
    • 33744928372 scopus 로고    scopus 로고
    • Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex
    • Snijder E.J., van der Meer Y., Zevenhoven-Dobbe J., Onderwater J.J., van der Meulen J., Koerten H.K., et al. Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J. Virol. 2006, 80(12):5927-5940.
    • (2006) J. Virol. , vol.80 , Issue.12 , pp. 5927-5940
    • Snijder, E.J.1    van der Meer, Y.2    Zevenhoven-Dobbe, J.3    Onderwater, J.J.4    van der Meulen, J.5    Koerten, H.K.6
  • 27
    • 15244348284 scopus 로고    scopus 로고
    • Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease?
    • Sulea T., Lindner H.A., Purisima E.O., Menard R. Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease?. J. Virol. 2005, 79(7):4550-4551.
    • (2005) J. Virol. , vol.79 , Issue.7 , pp. 4550-4551
    • Sulea, T.1    Lindner, H.A.2    Purisima, E.O.3    Menard, R.4
  • 28
    • 33646238014 scopus 로고    scopus 로고
    • Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus
    • Spiegel M., Weber F. Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus. Virol. J. 2006, 3:17.
    • (2006) Virol. J. , vol.3 , pp. 17
    • Spiegel, M.1    Weber, F.2
  • 29
    • 77954461006 scopus 로고    scopus 로고
    • The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions
    • Sun Z., Chen Z., Lawson S.R., Fang Y. The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions. J. Virol. 2010, 84(15):7832-7846.
    • (2010) J. Virol. , vol.84 , Issue.15 , pp. 7832-7846
    • Sun, Z.1    Chen, Z.2    Lawson, S.R.3    Fang, Y.4
  • 30
    • 84861309941 scopus 로고    scopus 로고
    • Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15
    • Sun Z., Li Y., Ransburgh R., Snijder E.J., Fang Y. Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J. Virol. 2012, 86(7):3839-3850.
    • (2012) J. Virol. , vol.86 , Issue.7 , pp. 3839-3850
    • Sun, Z.1    Li, Y.2    Ransburgh, R.3    Snijder, E.J.4    Fang, Y.5
  • 31
    • 84862895252 scopus 로고    scopus 로고
    • SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon
    • Totura A.L., Baric R.S. SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon. Curr. Opin. Virol. 2012, 2(3):264-275.
    • (2012) Curr. Opin. Virol. , vol.2 , Issue.3 , pp. 264-275
    • Totura, A.L.1    Baric, R.S.2
  • 32
    • 84871415482 scopus 로고    scopus 로고
    • Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans
    • van Boheemen S., de Graaf M., Lauber C., Bestebroer T.M., Raj V.S., Zaki A.M., et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio 2012, 3(6):10.
    • (2012) mBio , vol.3 , Issue.6 , pp. 10
    • van Boheemen, S.1    de Graaf, M.2    Lauber, C.3    Bestebroer, T.M.4    Raj, V.S.5    Zaki, A.M.6
  • 34
    • 84856844697 scopus 로고    scopus 로고
    • Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling
    • van Kasteren P.B., Beugeling C., Ninaber D.K., Frias-Staheli N., van Boheemen S., Garcia-Sastre A., et al. Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling. J. Virol. 2012, 86(2):773-785.
    • (2012) J. Virol. , vol.86 , Issue.2 , pp. 773-785
    • van Kasteren, P.B.1    Beugeling, C.2    Ninaber, D.K.3    Frias-Staheli, N.4    van Boheemen, S.5    Garcia-Sastre, A.6
  • 35
    • 12144285615 scopus 로고    scopus 로고
    • Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome
    • Wong C., Lam C., Wu A., Ip W., Lee N., Chan I., et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin. Exp. Immunol. 2004, 136(1):95-103.
    • (2004) Clin. Exp. Immunol. , vol.136 , Issue.1 , pp. 95-103
    • Wong, C.1    Lam, C.2    Wu, A.3    Ip, W.4    Lee, N.5    Chan, I.6
  • 36
    • 84879142678 scopus 로고    scopus 로고
    • The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase
    • Xing Y., Chen J., Tu J., Zhang B., Chen X., Shi H., et al. The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase. J. Gen. Virol. 2013, 94(Pt 7):1554-1567.
    • (2013) J. Gen. Virol. , vol.94 , Issue.PART 7 , pp. 1554-1567
    • Xing, Y.1    Chen, J.2    Tu, J.3    Zhang, B.4    Chen, X.5    Shi, H.6
  • 37
    • 77649277983 scopus 로고    scopus 로고
    • Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection
    • Yoshikawa T., Hill T., Yoshikawa N., Popov V., Galindo C., Garner H., et al. Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection. PLoS One 2010, 5(1):e8729.
    • (2010) PLoS One , vol.5 , Issue.1
    • Yoshikawa, T.1    Hill, T.2    Yoshikawa, N.3    Popov, V.4    Galindo, C.5    Garner, H.6
  • 39
    • 55549102621 scopus 로고    scopus 로고
    • PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production
    • Zheng D., Chen G., Guo B., Cheng G., Tang H. PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production. Cell Res. 2008, 18(11):1105-1113.
    • (2008) Cell Res. , vol.18 , Issue.11 , pp. 1105-1113
    • Zheng, D.1    Chen, G.2    Guo, B.3    Cheng, G.4    Tang, H.5
  • 40
    • 78751637122 scopus 로고    scopus 로고
    • Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
    • Zust R., Cervantes-Barragan L., Habjan M., Maier R., Neuman B.W., Ziebuhr J., et al. Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat. Immunol. 2011, 12(2):137-143.
    • (2011) Nat. Immunol. , vol.12 , Issue.2 , pp. 137-143
    • Zust, R.1    Cervantes-Barragan, L.2    Habjan, M.3    Maier, R.4    Neuman, B.W.5    Ziebuhr, J.6
  • 41
    • 84862297105 scopus 로고    scopus 로고
    • Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology
    • Zhao L., Jha B., Wu A., Elliott R., Ziebuhr J., Gorbalenya A., et al. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe 2012, 11(6):607-616.
    • (2012) Cell Host Microbe , vol.11 , Issue.6 , pp. 607-616
    • Zhao, L.1    Jha, B.2    Wu, A.3    Elliott, R.4    Ziebuhr, J.5    Gorbalenya, A.6


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