Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 9, 2013, Pages

  Van Kasteren, Puck B ^a   Bailey Elkin, Ben A ^b   James, Terrence W ^b   Ninaber, Dennis K ^a   Beugeling, Corrine ^a   Khajehpour, Mazdak ^b   Snijder, Eric J ^a   Mark, Brian L ^b   Kikkert, Marjolein ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

+RNA; Interferon stimulated gene 15; ISG15

Indexed keywords

BETA INTERFERON; DEUBIQUITINASE; LIVE VACCINE; MESSENGER RNA; PAPAIN LIKE PROTEASE 2; PROTEINASE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTERIVIRUS; ARTERIVIRUS INFECTION; ARTICLE; BINDING SITE; CELL LEVEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME SPECIFICITY; HOST CELL; HUMAN; HUMAN CELL; IMMUNE EVASION; IMMUNE RESPONSE; IMMUNOREGULATION; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; UBIQUITINATION; VIRUS REPLICATION;

ANIMALS; ARTERITIS VIRUS, EQUINE; ENDOPEPTIDASES; FIBROBLASTS; HEK293 CELLS; HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO; HORSES; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INTERFERON-BETA; MODELS, MOLECULAR; MUTATION; PAPAIN; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; UBIQUITIN; VIRUS REPLICATION; ZINC FINGERS;

EID: 84874504652     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218464110     Document Type: Article

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