Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis

Immunity

Volumn 41, Issue 6, 2014, Pages 1001-1012

  Gaiha, Gaurav D ^a   McKim, Kevin J ^a   Woods, Matthew ^a   Pertel, Thomas ^b   Rohrbach, Janine ^a   Barteneva, Natasha ^c   Chin, Christopher R ^a,d   Liu, Dongfang ^e   Soghoian, Damien Z ^a   Cesa, Kevin ^a   Wilton, Shannon ^a   Waring, Michael T ^a,f   Chicoine, Adam ^a   Doering, Travis ^g   Wherry, E John ^h   Kaufmann, Daniel E ^a,i   Lichterfeld, Mathias ^a,j   Brass, Abraham L ^a,d   Walker, Bruce D ^a,f,j  

^a Koch Institute for Integrative Cancer Research   (United States)

^b Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; GAG PROTEIN; PDCD1 PROTEIN, HUMAN; PEPTIDE FRAGMENT; PROGRAMMED DEATH 1 RECEPTOR; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, HUMAN; SMALL INTERFERING RNA; TRANSCRIPTOME;

CD8+ T LYMPHOCYTE; CELL CULTURE; CELL PROLIFERATION; DISEASE COURSE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; METABOLISM; NECROSIS; PHYSIOLOGY; VIROLOGY; VIRUS LOAD;

CASPASE 8; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; DISEASE PROGRESSION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HIV; HIV CORE PROTEIN P24; HIV INFECTIONS; HUMANS; NECROSIS; PEPTIDE FRAGMENTS; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSCRIPTOME; VIRAL LOAD;

EID: 84918501014     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.12.011     Document Type: Article

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