Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism

EMBO Journal

Volumn 26, Issue 4, 2007, Pages 1068-1080

  Yao, Zhan ^a   Duan, Shanshan ^a   Hou, Dezhi ^a   Heese, Klaus ^b   Wu, Mian ^a,c  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Caspase 8 Mch5; Death effector domain; ERK1 2; p53; TOPORS

Indexed keywords

AMINO ACID; ASPARTIC ACID; CARRIER PROTEINS AND BINDING PROTEINS; CASPASE 8; DNA TOPOISOMERASE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROCASPASE 8; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; FEEDBACK SYSTEM; GENE EXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TRANSPORT; RNA INTERFERENCE; UPREGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; APOPTOSIS; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 8; CELL NUCLEUS; DNA CLEAVAGE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 33847186990     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601571     Document Type: Article

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