Induced allostery in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 7, 2010, Pages 2775-2780

  Wu, Sheng ^a   Acevedo, Juan Pablo ^a   Reetz, Manfred T ^a  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

Author keywords

Allosteric effects; Enzymes; Molecular dynamics simulations; Protein engineering

Indexed keywords

UNSPECIFIC MONOOXYGENASE;

ALLOSTERISM; ARTICLE; BAEYER VILLIGER REACTION; BINDING SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME STRUCTURE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY;

ACETONE; ALLOSTERIC REGULATION; DIRECTED MOLECULAR EVOLUTION; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MUTAGENESIS; TEMPERATURE;

EID: 77649260900     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911656107     Document Type: Article

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