Young capillary vessels rejuvenate aged pancreatic islets

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 49, 2014, Pages 17612-17617

  Almaça, Joana ^a,b   Molina, Judith ^a   Drigo, Rafael Arrojoe ^a,c,d   Abdulreda, Midhat H ^a   Jeon, Won Bae ^b   Berggren, Per Olof ^a,c,d,e   Caicedo, Alejandro ^a,b   Nam, Hong Gil ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Aging; Glucose metabolism; Insulin secretion; Pancreatic islets; Vasculature

Indexed keywords

GLUCOSE; INSULIN; GLUCOSE BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR EYE CHAMBER; ARTICLE; BLOOD VESSEL; CAPILLARY; CELL FUNCTION; CELL PROLIFERATION; DIABETES MELLITUS; FIBROSIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; REVASCULARIZATION; VASCULARIZATION; ANIMAL; C57BL MOUSE; CYTOLOGY; HOMEOSTASIS; METABOLISM; MIDDLE AGED; PERFUSION; PHYSIOLOGY; TIME; YOUNG ADULT;

MUS;

ADOLESCENT; ADULT; AGED; AGING; ANIMALS; BLOOD GLUCOSE; CAPILLARIES; CELL PROLIFERATION; FIBROSIS; GLUCOSE; HOMEOSTASIS; HUMANS; INFLAMMATION; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PERFUSION; TIME FACTORS; YOUNG ADULT;

EID: 84917711043     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414053111     Document Type: Article

References (51)

1. Chang AM, Halter JB (2003) Aging and insulin secretion. Am J Physiol Endocrinol Metab 284(1):E7-E12.
2. Gu Z, et al. (2012) Effect of aging on islet beta-cell function and its mechanisms in Wistar rats. Age (Dordr) 34(6):1393-1403.
3. Gumbiner B, et al. (1989) Effects of aging on insulin secretion. Diabetes 38(12): 1549-1556.
4. Ihm SH, et al. (2007) Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets. Diabetes Res Clin Pract 77(Suppl 1): S150-S154.
5. Leiter EH, Premdas F, Harrison DE, Lipson LG (1988) Aging and glucose homeostasis in C57BL/6J male mice. FASEB J 2(12):2807-2811.
6. Muzumdar R, et al. (2004) Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. Diabetes 53(2):441-446.
7. Kushner JA (2013) The role of aging upon β cell turnover. J Clin Invest 123(3):990-995.
8. Szoke E, et al. (2008) Effect of aging on glucose homeostasis: Accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance. Diabetes Care 31(3):539-543.
9. Li L, et al. (2014) Defects in β-Cell Ca2+ Dynamics in Age-Induced Diabetes. Diabetes 1, 10.2337/db13-1855.
10. Basu R, et al. (2003) Mechanisms of the age-associated deterioration in glucose tolerance: Contribution of alterations in insulin secretion, action, and clearance. Diabetes 52(7):1738-1748.
11. Muller DC, Elahi D, Tobin JD, Andres R (1996) The effect of age on insulin resistance and secretion: A review. Semin Nephrol 16(4):289-298.
12. Salpeter SJ, et al. (2013) Systemic regulation of the age-related decline of pancreatic β-cell replication. Diabetes 62(8):2843-2848.
13. Zhu G, et al. (2009) Young environment reverses the declined activity of aged rat-derived endothelial progenitor cells: Involvement of the phosphatidylinositol 3-kinase/Akt signaling pathway. Ann Vasc Surg 23(4):519-534.
14. Katsimpardi L, et al. (2014) Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 344 (6184):630-634.
15. Sinha M, et al. (2014) Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science 344 (6184):649-652.
16. Villeda SA, et al. (2014) Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 20(6):659-663.
17. Rodriguez-Diaz R, et al. (2012) Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function. Proc Natl Acad Sci USA 109(52): 21456-21461.
18. Brissova M, et al. (2005) Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 53(9): 1087-1097.
19. Cabrera O, et al. (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 103(7):2334-2339.
20. Cnop M, et al. (2011) Longevity of human islet α-and β-cells. Diabetes Obes Metab 13(Suppl 1):39-46.
21. Toye AA, et al. (2005) A genetic and physiological study of impaired glucose ho-meostasis control in C57BL/6J mice. Diabetologia 48(4):675-686.
22. Saisho Y, et al. (2013) β-cell mass and turnover in humans: Effects of obesity and aging. Diabetes Care 36(1):111-117.
23. Paré WP, Glavin GB (1986) Restraint stress in biomedical research: A review. Neurosci Biobehav Rev 10(3):339-370.
24. Chung HY, et al. (2009) Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Res Rev 8(1):18-30.
25. Lawson C, Wolf S (2009) ICAM-1 signaling in endothelial cells. Pharmacolog Rep 61(1): 22-32.
26. Chen W, Frangogiannis NG (2010) The role of inflammatory and fibrogenic pathways in heart failure associated with aging. Heart Fail Rev 15(5):415-422.
27. Kapetanaki MG, Mora AL, Rojas M (2013) Influence of age on wound healing and fibrosis. J Pathol 229(2):310-322.
28. Mak KM, Chen LL, Lee TF (2013) Codistribution of collagen type IV and laminin in liver fibrosis of elderly cadavers: Immunohistochemical marker of perisinusoidal basement membrane formation. Anat Rec (Hoboken) 296(6):953-964.
29. Wynn TA, Barron L (2010) Macrophages: Master regulators of inflammation and fi-brosis. Semin Liver Dis 30(3):245-257.
30. Nyqvist D, et al. (2011) Donor islet endothelial cells in pancreatic islet re-vascularization. Diabetes 60(10):2571-2577.
31. Speier S, et al. (2008) Noninvasive in vivo imaging of pancreatic islet cell biology. Nat Med 14(5):574-578.
32. Chen X, et al. (2009) Comparative study of regenerative potential of beta cells from young and aged donor mice using a novel islet transplantation model. Transplantation 88(4):496-503.
33. Stolovich-Rain M, Hija A, Grimsby J, Glaser B, Dor Y (2012) Pancreatic beta cells in very old mice retain capacity for compensatory proliferation. J Biol Chem 287(33): 27407-27414.
34. Bonner-Weir S, Orci L (1982) New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31(10):883-889.
35. Guyton AC, Hall JE (2006) Textbook of Medical Physiology (Elsevier Health Sciences, Philadelphia, PA), 11th Ed.
36. Flurkey KCJ, Harrison DE (2007) The Mouse in Aging Research (Elsevier Academic Press, Burlington, MA), pp 637-672.
37. Kappel VD, et al. (2013) The role of calcium in intracellular pathways of rutin in rat pancreatic islets: Potential insulin secretagogue effect. Eur J Pharmacol 702(1-3): 264-268.
38. Lin HM, et al. (2009) Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function. J Biol Chem 284(18): 12246-12257.
39. Starnes JW, Cheong E, Matschinsky FM (1991) Hormone secretion by isolated perfused pancreas of aging Fischer 344 rats. Am J Physiol 260(1 Pt 1):E59-E66.
40. Wu D, et al. (2007) Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J Immunol 179(7):4829-4839.
41. Utzschneider KM, et al. (2004) Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function. Diabetes 53(11):2867-2872.
42. Sandovici I, et al. (2011) Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci USA 108(13):5449-5454.
43. Svensson AM, Abdel-Halim SM, Efendic S, Jansson L, Ostenson CG (1994) Pancreatic and islet blood flow in F1-hybrids of the non-insulin-dependent diabetic GK-Wistar rat. Eur J Endocrinol 130(6):612-616.
44. Svensson AM, Bodin B, Andersson A, Jansson L (2004) Pancreatic islet blood flow during pregnancy in the rat: An increased islet mass is associated with decreased islet blood flow. J Endocrinol 180(3):409-415.
45. Carlsson PO, Jansson L, Ostenson CG, Källskog O (1997) Islet capillary blood pressure increase mediated by hyperglycemia in NIDDM GK rats. Diabetes 46(6):947-952.
46. Szmitko PE, et al. (2003) New markers of inflammation and endothelial cell activation: Part I. Circulation 108(16):1917-1923.
47. Gorini S, Gatta L, Pontecorvo L, Vitiello L, la Sala A (2013) Regulation of innate immunity by extracellular nucleotides. Am J Blood Res 3(1):14-28.
48. Jacob F, Pérez Novo C, Bachert C, Van Crombruggen K (2013) Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal 9(3):285-306.
49. Jacques-Silva MC, et al. (2010) ATP-gated P2X3 receptors constitute a positive auto-crine signal for insulin release in the human pancreatic beta cell. Proc Natl Acad Sci USA 107(14):6465-6470.
50. Homo-Delarche F, et al. (2006) Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat. Diabetes 55(6):1625-1633.
51. Brissova M, et al. (2004) Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes 53(5):1318-1325.