ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 14, 2010, Pages 6465-6470

  Jacques Silva, M Caroline ^a   Correa Medina, Mayrin ^a   Cabrera, Over ^a   Rodriguez Diaz, Rayner ^a   Makeeva, Natalia ^a   Fachado, Alberto ^a   Diez, Juan ^a   Berman, Dora M ^a   Kenyon, Norma S ^a   Ricordi, Camillo ^a,b   Pileggi, Antonello ^a   Molano, R Damaris ^a   Berggren, Per Olof ^a,b   Caicedo, Alejandro ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Extracellular ATP; Human pancreatic cell; Insulin secretion; P2X receptor; Positive autocrine feedback

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; GLUCOSE; INSULIN; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2 RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; HORMONE RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; INSULIN RELEASE; PANCREAS ISLET BETA CELL; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; GENETICS; METABOLISM; SECRETION;

RODENTIA;

ADENOSINE TRIPHOSPHATE; AUTOCRINE COMMUNICATION; CALCIUM; HUMANS; INSULIN; INSULIN-SECRETING CELLS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 77950885567     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908935107     Document Type: Article

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