Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets

Diabetes Research and Clinical Practice

Volumn 77, Issue 3 SUPPL., 2007, Pages

  Ihm, Sung Hee ^a   Moon, Hong Ju ^a   Kang, Jun Goo ^a   Park, Cheol Young ^a   Oh, Ki Won ^a   Jeong, In Kyung ^a   Oh, Yang Seok ^b   Park, Sung Woo ^a  

^a Hallym University   (South Korea)

^b Hallym University   (South Korea)

Author keywords

Aging; Beta cell; Insulin; PDX 1; Type 2 diabetes

Indexed keywords

CASPASE 3; FURIN; GLUCOSE TRANSPORTER 2; GLYCEROL KINASE; HEPATOCYTE NUCLEAR FACTOR 3BETA; INSULIN; MANGANESE SUPEROXIDE DISMUTASE; PROPROTEIN CONVERTASE 1; TRANSCRIPTION FACTOR PDX 1; UNCOUPLING PROTEIN 2;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL ISOLATION; CONTROLLED STUDY; DNA CONTENT; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; LONG EVANS RAT; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PHYSICAL ACTIVITY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS;

AGING; ANIMALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE TRANSPORTER TYPE 2; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; RATS; RATS, INBRED STRAINS; RATS, LONG-EVANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 34547679883     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2007.01.049     Document Type: Article

References (22)

1. Harris M.I., Flegal K.M., Cowie C.C., Eberhardt M.S., Goldstein D.E., Little R.R., et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults: the third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care 21 (1998) 518-524
2. Resnick H.E., Harris M.I., Brock D.B., and Harris T.B. American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: results from the Third National Health and Nutrition Examination Survey. Diabetes Care 23 (2000) 176-180
3. DeFronzo R. Glucose intolerance and aging. Diabetes Care 4 (1981) 493-501
4. Chang A.M., and Halter J.B. Aging and insulin secretion. Am J Physiol Endocrinol Metab 284 (2003) E7-E12
5. Scheen A.J. Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?. Diabetes Metab 2 (2005) 5S27-5S34
6. Basu R., Breda E., Oberg A.L., Powell C.C., Dalla Man C., Basu A., et al. Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes 52 (2003) 1738-1748
7. Ihm S.H., Matsumoto I., Sawada T., Nakano M., Zhang H.J., Ansite J.D., et al. Effect of donor age on function of isolated human islets. Diabetes 55 (2006) 1361-1368
8. Lavrovsky Y., Chatterjee B., Clark R.A., and Roy A.K. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 35 (2000) 521-532
9. Chakrabarti S.K., and Mirmira R.G. Transcription factors direct the development and function of pancreatic b cells. TRENDS Endocrinol Metab 14 (2003) 78-84
10. McKinnon C.M., and Docherty K. Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function. Diabetologia 44 (2001) 1203-1214
11. Perfetti R., Montrose-Rafizadeh C., Liotta A., and Egan J.M. Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. Am J Physiol 269 (1995) E983-E990
12. Rhodes C.J. Type 2 diabetes-a matter of beta-cell life and death?. Science 307 (2005) 380-384
13. Brissova M., Shiota M., Nicholson W.E., Gannon M., Knobel S.M., Piston D.W., et al. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 277 (2002) 11225-11232
14. Gauthier B.R., Brun T., Sarret E.J., Ishihara H., Schaad O., Descombes P., et al. Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J Biol Chem 279 (2004) 31121-31130
15. Wang H., Iezzi M., Theander S., Antinozzi P.A., Gauthier B.R., Halban P.A., et al. Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. Diabetologia 48 (2005) 720-731
16. Fritsche A., Madaus A., Stefan N., Tschritter O., Maerker E., Teigeler A., et al. Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans. Diabetes 51 Suppl 1 (2002) S234-S239
17. Perfetti R., Zhou J., Doyle M.E., and Egan J.M. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141 (2000) 4600-4605
18. Kaneto H., Matsuoka T., Nakatani Y., Kawamori D., Miyatsuka T., Matsuhisa M., et al. Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes. J Mol Med 83 (2005) 429-439
19. Nakae J., Biggs W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 32 (2002) 245-253
20. Drucker D.J. Minireview: the glucagon-like peptides. Endocrinology 142 (2001) 521-527
21. Buteau J., Roduit R., Susini S., and Prentki M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42 (1999) 856-864
22. Stoffers D.A., Kieffer T.J., Hussain M.A., Drucker D.J., Bonner-Weir S., Habener J.F., et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49 (2000) 741-748