Research treatment of tecurrent malignant gliomas with chronic oral high-dose tamoxifen

Clinical Cancer Research

Volumn 2, Issue 4, 1996, Pages 619-622

  Couldwell, William T ^a,c   Hinton, David R ^a   Surnock, Amy A ^a   DeGiorgio, Christopher M ^a   Weiner, Leslie P ^a   Apuzzo, Michael L J ^a   Masri, Lena ^b   Law, Ronald E ^a   Weiss, Martin H ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TAMOXIFEN;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; FEMALE; GLIOMA; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; AGED; ESTROGEN ANTAGONISTS; FEMALE; GLIOMA; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROSPECTIVE STUDIES; PROTEIN KINASE C; TAMOXIFEN;

EID: 0030002074     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Baltuch, G., Couldwell, W. T., Villemure, J. G., and Yong, V. W. Protein kinase C inhibitors suppress cell growth in established and low passage glioma cell lines. A comparison between staurosporine and tamoxifen. Neurosurgery, 33: 495-501, 1993.
2. Couldwell, W T., Antel, J. P., and Yong, V. W. Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of PKC. Neurosurgery, 31: 717-724, 1992.
3. Couldwell, W. T., Uhm, J., Antel, J. P., and Yong, V. W. Enhanced protein kinase C activity correlates with the growth rate of malignant human gliomas. Neurosurgery, 29: 880-887, 1991.
4. Nisruzuka, Y. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science (Washington DC), 258: 607-614, 1992.
5. O'Brian, C. A., Liskamp, R. M., Solomon, D. H., and Weinstein, I. B. Inhibition of protein kinase C by tamoxifen. Cancer Res., 45: 2462-2465, 1985
6. Pollack, I. F., Randall, M. S., Kristofik, M. P., Kelly, R. H., Selker, R. G., and Vertosik, F. T. Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. Cancer Res., 50: 7134-7138, 1990.
7. Vertosik, F. T., Selker, R. G , Pollack, I. F., and Arena, V. The treatment of intracranial malignant gliomas using orally administered tamoxifen therapy: preliminary results in a series of "failed" patients. Neurosurgery, 30: 897-903, 1992.
8. Couldwell, W. T., Hinton, D, R., He, S., Chen, T., Sabit, I., Weiss, M. H., and Law, R Protein kinase C inhibitors induce apoptosis in human malignant glioma lines. FEBS Lett., 345: 43-46, 1994.
9. Pollack, I. F., and Kawecki, S. The efficacy of tamoxifen as an antiproliferative agent in vitro for benign and malignant pediatric glial tumors. Pediatr. Neurosurg., 22: 281-288, 1995.
10. Couldwell, W. T., Weiss, M. H., Weiner, L. P., DeGiorgio, C. M., Hinton, D. R., Ehresmann. G. R., Conti, P. S., and Apuzzo, M. L. J. Clinical and radiographic response in a minority of patients with recurrent malignant ghomas treated with high dose tamoxifen. Preliminary report. Neurosurgery, 32: 485-490, 1993
11. Zhang, W., Yamada, H., Sakai, N., Niikawa, S., and Nozawa, Y. Enhancement of radiosensitivity by tamoxifen in C6 glioma cells. Neurosurgery, 31: 725-730, 1992.
12. Zhang, W., Anter, R., Law, R. E., Hinton, D. R., Gopalakrishna, R., Pu, Q., Gundimeda, U., Weiss, M. H., and Couldwell, W. T. Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vilro. Clin. Cancer Res., in press, 1996.