Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device

Electrophoresis

Volumn 31, Issue 18, 2010, Pages 3167-3174

  Yeon, Ju Hun ^a   Na, Dokyun ^a   Park, Je Kyun ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Cell trapping; Hepatotoxicity assay; Microfluidic device; Primary human hepatocyte

Indexed keywords

ASSAYS; FLUIDIC DEVICES; MICROFLUIDICS;

ASSAY SYSTEM; CELL TRAPPING; HEPATOCYTES; HEPATOTOXICITY; HEPATOTOXICITY ASSAY; HUMAN HEPATOCYTES; IN-VITRO; MICRO HOLES; MICROFLUIDICS DEVICES; PRIMARY HUMAN HEPATOCYTES;

CELL DEATH;

BENZO[A]PYRENE; DICLOFENAC; PARACETAMOL; VERAPAMIL;

ARTICLE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LC 50; LIVER CELL CULTURE; LIVER TOXICITY; MICROFLUIDICS; TOXICITY TESTING;

EID: 77956928883     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201000122     Document Type: Article

References (28)

1. Richert, L., Liguori, M. J., Abadie, C., Heyd, B., Mantion, G., Halkic, N., Waring, J. F., Drug Metab. Dispos. 2006, 34, 870-879.
2. Li, A. P., Lu, C., Brent, J. A., Pham, C., Fackett, A., Ruegg, C. E., Silber, P. M., Chem.Biol. Interact. 1999, 121, 17-35.
3. Guillouzo, A., Environ. Health Persp. 1998, 106, 511-532.
4. Khetani, S. R., Bhatia, S. N., Nat. Biotechnol. 2008, 26, 120-126.
5. Elaut, G., Papeleu, P., Vinken, M., Henkens, T., Snykers, S., Vanhaecke, T., Rogiers, V., in: Phillips, I. R., Shephard, E. A. (Eds.), Cytochrome P450 Protocols, Vol. 320, Humana Press, Heidelberg 2005, pp. 255-263.
6. Navarro, V. J., Senior, J. R., N. Engl. J. Med. 2006, 354, 731-739.
7. Bort, R., Ponsoda, X., Jover, R., Gómez-Lechón, M. J, Castell, J. V., J. Pharmacol. Exp. Ther. 1998, 288, 65-72.
8. Viravaidya, K., Sin, A., Shuler, M. L., Biotechnol. Prog. 2004, 20, 316-323.
9. Wilkening, S., Stahl, F., Bader, A., Drug Metab. Dispos. 2003, 31, 1035-1042.
10. Wang, K., Shindoh, H., Inoue, T., Horii, I., J. Toxicol. Sci. 2002, 27, 229-237.
11. Červenková, K., Belejová, M., Veselý, J., Chmela, Z., Rypka, M., Ulrichová, J., Modrianský, M., Maurel, P., Biomed. Papers 2001, 145, 57-60.
12. Kaplowitz, N., Nat. Rev. Drug Discov. 2005, 4, 489-499.
13. Li, A. P., Drug Discov. Today 2001, 6, 357-366.
14. Skett, P., Toxicol. In Vitro 1994, 8, 491-504.
15. Ma, B., Zhang, G., Qin, J., Lin, B., Lab Chip 2009, 9, 232-238.
16. Kane, B. J., Zinner, M. J., Yarmush, M. L., Toner, M., Anal. Chem. 2006, 78, 4291-4298.
17. Lee, P. J., Hung, P. J., Lee, L. P., Biotechnol. Bioeng. 2007, 97, 1340-1346.
18. Toh, Y. C., Ng, S., Khong, Y. M., Samper, V., Yu, H., Assay Drug Dev. Technol. 2005, 3, 169-176.
19. Toh, Y. C., Zhang, C., Zhang, J., Khong, Y. M., Chang, S., Samper, V. D., van Noort, D., Hutmacher, D. W., Yu, U. H., Lab Chip 2007, 7, 302-309.
20. Ong, S. M., Zhang, C., Toh, Y. C., Kim, S. H., Foo, H. L., Tan, C. H., van Noort, D., Park, S., Yu, H., Biomaterials 2008, 29, 3237-3244.
21. Yeon, J. H., Park, J.-K., Anal. Chem. 2009, 81, 1944-1951.
22. Shrivastava, R., Delomenie, C., Chevalier, A., John, G., Ekwall, B., Walum, E., Massingham, R., Cell Biol. Toxicol. 1992, 8, 157-170.
23. Yeon, J. H., Park, J.-K., Anal. Biochem. 2005, 341, 308-315.
24. Jouin, D., Blanchard, N., Alexandre, E., Delobel, F., David-Pierson, P., Lavé, T., Jaeck, D., Richert, L., Coassolo, P., Eur. J. Pharm. Biopharm. 2006, 63, 347-355.
25. James, L. P., Mayeux, P. R., Hinson, J. A., Drug Metab. Dispos. 2003, 31, 1499-1506.
26. Dai, Y., Cederbaum, A. I., J. Pharmacol. Exp. Ther. 1995, 273, 1497-1505.
27. Kumar, K. L., Colley, C. A., West J. Med. 1994, 160, 485-486.
28. Boelsterli, U. A., Toxicol. Appl. Pharmacol. 2003, 192, 307-322.