Interplay of lna and 2- o -methyl rna in the structure and thermodynamics of rna hybrid systems: A molecular dynamics study using the revised amber force field and comparison with experimental results

Journal of Physical Chemistry B

Volumn 118, Issue 49, 2014, Pages 14177-14187

  Yildirim, Ilyas ^a   Kierzek, Elzbieta ^b   Kierzek, Ryszard ^b   Schatz, George C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

AMBER; BINDING ENERGY; BIOMOLECULES; FORECASTING; FREE ENERGY; GENE EXPRESSION; HYBRID SYSTEMS; MOLECULAR DYNAMICS; RNA; STABILITY;

BINDING FREE ENERGY; COMPUTATIONAL PREDICTIONS; HYBRIDIZATION MECHANISM; LOCKED NUCLEIC ACID; MOLECULAR DYNAMICS SIMULATIONS; RNA MODIFICATIONS; STRUCTURAL RIGIDITY; STRUCTURAL STABILITIES;

BIOINFORMATICS;

LOCKED NUCLEIC ACID; OLIGONUCLEOTIDE; RNA;

CHEMISTRY; COMPARATIVE STUDY; COMPUTER PROGRAM; CONFORMATION; METHYLATION; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; THERMODYNAMICS;

BASE SEQUENCE; METHYLATION; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; RNA; SOFTWARE; THERMODYNAMICS;

EID: 84916878768     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp506703g     Document Type: Article

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