A glycine-dependent riboswitch that uses cooperative binding to control gene expression

Science

Volumn 306, Issue 5694, 2004, Pages 275-279

  Mandal, Maumita ^a   Lee, Mark ^a   Barrick, Jeffrey E ^a   Weinberg, Zasha ^b   Emilsson, Gail Mitchell ^a   Ruzzo, Walter L ^b,c   Breaker, Ronald R ^a  

^a YALE UNIVERSITY   (United States)

^b University of Washington   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS; RNA;

CITRIC ACID; GLYCINE; RIBOSWITCH;

GENETIC ENGINEERING;

BACTERIAL RNA; GLYCINE; GLYCINE CLEAVAGE SYSTEM; MESSENGER RNA;

BIOCHEMISTRY; BIOLOGY; GENETICS;

ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CITRIC ACID CYCLE; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC CODE; LIGAND BINDING; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

5' UNTRANSLATED REGIONS; ALLOSTERIC REGULATION; ALLOSTERIC SITE; BACILLUS SUBTILIS; BASE PAIRING; BASE SEQUENCE; BINDING SITES; GENE EXPRESSION REGULATION, BACTERIAL; GLYCINE; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; OPERON; RNA, BACTERIAL; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VIBRIO CHOLERAE;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); PROKARYOTA;

EID: 5044234799     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1100829     Document Type: Article

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30. We thank members of the Breaker laboratory for helpful discussions and G. Reguera and B. Bassler for providing genomic DNA for V. cholerae. This work was supported by grants from the NIH and the NSF. R.R.B. is also grateful for support from the Yale Liver Center and the David and Lucile Packard Foundation.