Defining the secondary structural requirements of a cocaine-binding aptamer by a thermodynamic and mutation study

Biophysical Chemistry

Volumn 153, Issue 1, 2010, Pages 9-16

  Neves, Miguel A D ^a,b   Reinstein, Oren ^a   Saad, Makbul ^a   Johnson, Philip E ^a  

^a YORK UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cp; Change in heat capacity; Dissociation constant; Isothermal titration calorimetry; ITC; Kd; NMR; Nuclear magnetic resonance

Indexed keywords

APTAMER; COCAINE; COCAINE BINDING APTAMER; LIGAND; NUCLEOTIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); IONIC STRENGTH; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR INTERACTION; MUTATION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN VARIANT; THERMODYNAMICS;

APTAMERS, NUCLEOTIDE; BASE SEQUENCE; COCAINE; HYDROGEN-ION CONCENTRATION; MUTATION; NUCLEIC ACID CONFORMATION; OSMOLAR CONCENTRATION; THERMODYNAMICS;

EID: 78649751474     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2010.09.009     Document Type: Article

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