메뉴 건너뛰기




Volumn 347, Issue 3, 2012, Pages 689-699

Environmental parameters influence non-viral transfection of human mesenchymal stem cells for tissue engineering applications

Author keywords

Adult stem cells; Bioprocessing; Multipotency; Polyethyleneimine; Toxicity

Indexed keywords

DNA; ENDOGLIN;

EID: 84862797394     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-011-1297-0     Document Type: Article
Times cited : (28)

References (63)
  • 1
    • 34248672837 scopus 로고    scopus 로고
    • Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity
    • DOI 10.1016/j.addr.2007.03.010, PII S0169409X07000245, Opportunities and Challenges for Therapeutic Gene Silencing using RNAi and microRNA Technologies
    • Akhtar S, Benter I (2007) Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv Drug Deliv Rev 59:164-182 (Pubitemid 46773052)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.2-3 , pp. 164-182
    • Akhtar, S.1    Benter, I.2
  • 2
    • 77949424738 scopus 로고    scopus 로고
    • Phase- I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer
    • Anwer K, Barnes MN, Fewell J, Lewis DH, Alvarez RD (2010) Phase- I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer. Gene Ther 17:360-369
    • (2010) Gene Ther , vol.17 , pp. 360-369
    • Anwer, K.1    Barnes, M.N.2    Fewell, J.3    Lewis, D.H.4    Alvarez, R.D.5
  • 3
    • 0034332270 scopus 로고    scopus 로고
    • Serum as a modulator of lipoplex-mediated gene transfection: Dependence of amphiphile, cell type and complex stability
    • Audouy S, Molema G, de Leij L, Hoekstra D (2000) Serum as a modulator of lipoplex-mediated gene transfection: dependence of amphiphile, cell type and complex stability. J Gene Med 2:465-476
    • (2000) J Gene Med , vol.2 , pp. 465-476
    • Audouy, S.1    Molema, G.2    De Leij, L.3    Hoekstra, D.4
  • 4
    • 34547122719 scopus 로고    scopus 로고
    • Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow
    • DOI 10.1634/stemcells.2006-0709
    • Baksh D, Yao R, Tuan RS (2007) Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 25:1384-1392 (Pubitemid 47106005)
    • (2007) Stem Cells , vol.25 , Issue.6 , pp. 1384-1392
    • Baksh, D.1    Yao, R.2    Tuan, R.S.3
  • 5
    • 0033547347 scopus 로고    scopus 로고
    • The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105)
    • Barry FP, Boynton RE, Haynesworth S, Murphy JM, Zaia J (1999) The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun 265:134-139
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 134-139
    • Barry, F.P.1    Boynton, R.E.2    Haynesworth, S.3    Murphy, J.M.4    Zaia, J.5
  • 6
    • 51449111055 scopus 로고    scopus 로고
    • Non-viral delivery of the gene for glial cell line-derived neurotrophic factor to mesenchymal stem cells in vitro via a collagen scaffold
    • Bolliet C, Bohn MC, Spector M (2008) Non-viral delivery of the gene for glial cell line-derived neurotrophic factor to mesenchymal stem cells in vitro via a collagen scaffold. Tissue Eng Part C Methods 14:207-219
    • (2008) Tissue Eng Part C Methods , vol.14 , pp. 207-219
    • Bolliet, C.1    Bohn, M.C.2    Spector, M.3
  • 8
    • 0031750860 scopus 로고    scopus 로고
    • In vitro myotoxicity of selected cationic macromolecules used in non- viral gene delivery
    • DOI 10.1023/A:1011954516233
    • Brazeau GA, Attia S, Poxon S, Hughes JA (1998) In vitro myotoxicity of selected cationic macromolecules used in non-viral gene delivery. Pharm Res 15:680-684 (Pubitemid 28275642)
    • (1998) Pharmaceutical Research , vol.15 , Issue.5 , pp. 680-684
    • Brazeau, G.A.1    Attia, S.2    Poxon, S.3    Hughes, J.A.4
  • 9
    • 0031012465 scopus 로고    scopus 로고
    • Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation
    • DOI 10.1002/(SICI)1097-4644(199702)64:2<278::AID-JCB11>3.0.CO;2-F
    • Bruder SP, Jaiswal N, Haynesworth SE (1997) Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 64:278-294 (Pubitemid 27065442)
    • (1997) Journal of Cellular Biochemistry , vol.64 , Issue.2 , pp. 278-294
    • Bruder, S.P.1    Jaiswal, N.2    Haynesworth, S.E.3
  • 10
    • 0034059514 scopus 로고    scopus 로고
    • Cell cycle dependence of gene transfer by lipoplex polyplex and recombinant adenovirus
    • Brunner S, Sauer T, Carotta S, Cotten M, Saltik M, Wagner E (2000) Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Ther 7:401-407 (Pubitemid 30156552)
    • (2000) Gene Therapy , vol.7 , Issue.5 , pp. 401-407
    • Brunner, S.1    Sauer, T.2    Carotta, S.3    Cotten, M.4    Saltik, M.5    Wagner, E.6
  • 11
    • 11144221968 scopus 로고    scopus 로고
    • Exogenous Runx2 expression enhances in vitro osteoblastic differentiation and mineralization in primary bone marrow stromal cells
    • Byers BA, Garcia AJ (2004) Exogenous Runx2 expression enhances in vitro osteoblastic differentiation and mineralization in primary bone marrow stromal cells. Tissue Eng 10:1623-1632 (Pubitemid 40054204)
    • (2004) Tissue Engineering , vol.10 , Issue.11-12 , pp. 1623-1632
    • Byers, B.A.1    Garcia, A.J.2
  • 13
    • 0037340561 scopus 로고    scopus 로고
    • Monitoring of the formation and dissociation of polyethylenimine/DNA complexes by two photon fluorescence correlation spectroscopy
    • Clamme JP, Azoulay J, Mely Y (2003) Monitoring of the formation and dissociation of polyethylenimine/DNA complexes by two photon fluorescence correlation spectroscopy. Biophys J 84:1960-1968 (Pubitemid 36322958)
    • (2003) Biophysical Journal , vol.84 , Issue.3 , pp. 1960-1968
    • Clamme, J.P.1    Azoulay, J.2    Mely, Y.3
  • 15
    • 34547859690 scopus 로고    scopus 로고
    • A comparative evaluation of poly-l-lysine-palmitic acid and Lipofectamine 2000 for plasmid delivery to bone marrow stromal cells
    • DOI 10.1016/j.biomaterials.2007.07.023, PII S014296120700542X
    • Clements BA, Incani V, Kucharski C, Lavasanifar A, Ritchie B, Uludag H (2007a) A comparative evaluation of poly-L-lysine-palmitic acid and Lipofectamine 2000 for plasmid delivery to bone marrow stromal cells. Biomaterials 28:4693-4704 (Pubitemid 47259175)
    • (2007) Biomaterials , vol.28 , Issue.31 , pp. 4693-4704
    • Clements, B.A.1    Incani, V.2    Kucharski, C.3    Lavasanifar, A.4    Ritchie, B.5    Uludag, H.6
  • 16
    • 34547859690 scopus 로고    scopus 로고
    • A comparative evaluation of poly-l-lysine-palmitic acid and Lipofectamine (TM) 2000 for plasmid delivery to bone marrow stromal cells
    • DOI 10.1016/j.biomaterials.2007.07.023, PII S014296120700542X
    • Clements BA, Incani V, Kucharski C, Lavasanifar A, Ritchie B, Uludag H (2007b) A comparative evaluation of poly-L-lysine-palmitic acid and Lipofectamine (TM) 2000 for plasmid delivery to bone marrow stromal cells. Biomaterials 28:4693-4704 (Pubitemid 47259175)
    • (2007) Biomaterials , vol.28 , Issue.31 , pp. 4693-4704
    • Clements, B.A.1    Incani, V.2    Kucharski, C.3    Lavasanifar, A.4    Ritchie, B.5    Uludag, H.6
  • 18
    • 0037082158 scopus 로고    scopus 로고
    • High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells
    • Durocher Y, Perret S, Kamen A (2002) High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Res 30:E9
    • (2002) Nucleic Acids Res , vol.30
    • Durocher, Y.1    Perret, S.2    Kamen, A.3
  • 20
    • 33847309821 scopus 로고    scopus 로고
    • A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC)
    • Farrell LL, Pepin J, Kucharski C, Lin X, Xu Z, Uludag H (2007) A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC). Eur J Pharm Biopharm 65:388-397
    • (2007) Eur J Pharm Biopharm , vol.65 , pp. 388-397
    • Farrell, L.L.1    Pepin, J.2    Kucharski, C.3    Lin, X.4    Xu, Z.5    Uludag, H.6
  • 21
    • 0033912738 scopus 로고    scopus 로고
    • Protective copolymers for nonviral gene vectors: Synthesis, vector characterization and application in gene delivery
    • Finsinger D, Remy JS, Erbacher P, Koch C, Plank C (2000) Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery. Gene Ther 7:1183-1192 (Pubitemid 30488765)
    • (2000) Gene Therapy , vol.7 , Issue.14 , pp. 1183-1192
    • Finsinger, D.1    Remy, J.-S.2    Erbacher, P.3    Koch, C.4    Plank, C.5
  • 22
    • 0038004448 scopus 로고    scopus 로고
    • A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: Effect of molecular weight on transfection efficiency and cytotoxicity
    • DOI 10.1023/A:1014861900478
    • Fischer D, Bieber T, Li YX, Elsasser HP, Kissel T (1999) A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: Effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 16:1273-1279 (Pubitemid 29393618)
    • (1999) Pharmaceutical Research , vol.16 , Issue.8 , pp. 1273-1279
    • Fischer, D.1    Bieber, T.2    Li, Y.3    Elsasser, H.-P.4    Kissel, T.5
  • 23
    • 0242708765 scopus 로고    scopus 로고
    • Endoglin (CD105): A powerful therapeutic target on tumor-associated angiogenetic blood vessels
    • Fonsatti E, Altomonte M, Nicotra MR, Natali PG, Maio M (2003) Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels. Oncogene 22:6557-6563 (Pubitemid 37372335)
    • (2003) Oncogene , vol.22 , Issue.43 , pp. 6557-6563
    • Fonsatti, E.1    Altomonte, M.2    Nicotra, M.R.3    Natali, P.G.4    Maio, M.5
  • 24
    • 84989485234 scopus 로고
    • The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells
    • Friedenstein AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3:393-403
    • (1970) Cell Tissue Kinet , vol.3 , pp. 393-403
    • Friedenstein, A.J.1    Chailakhjan, R.K.2    Lalykina, K.S.3
  • 25
    • 58749101153 scopus 로고    scopus 로고
    • Reflections on more than 10 years of TGE approaches
    • Geisse S (2009) Reflections on more than 10 years of TGE approaches. Protein Expr Purif 64:99-107
    • (2009) Protein Expr Purif , vol.64 , pp. 99-107
    • Geisse, S.1
  • 26
    • 0032811354 scopus 로고    scopus 로고
    • Poly(ethylenimine) and its role in gene delivery
    • DOI 10.1016/S0168-3659(99)00090-5, PII S0168365999000905
    • Godbey WT, Wu KK, Mikos AG (1999) Poly(ethylenimine) and its role in gene delivery. J Control Release 60:149-160 (Pubitemid 29335941)
    • (1999) Journal of Controlled Release , vol.60 , Issue.2-3 , pp. 149-160
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 27
    • 0035284549 scopus 로고    scopus 로고
    • Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability
    • Godbey WT, Wu KK, Mikos AG (2001) Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability. Biomaterials 22:471-480
    • (2001) Biomaterials , vol.22 , pp. 471-480
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 28
    • 44949144097 scopus 로고    scopus 로고
    • Poly(lactic-co-glycolic acid) nanosphere as a vehicle for gene delivery to human cord blood-derived mesenchymal stem cells: Comparison with polyethylenimine
    • Gwak SJ, Kim BS (2008) Poly(lactic-co-glycolic acid) nanosphere as a vehicle for gene delivery to human cord blood-derived mesenchymal stem cells: comparison with polyethylenimine. Biotechnol Lett 30:1177-1182
    • (2008) Biotechnol Lett , vol.30 , pp. 1177-1182
    • Gwak, S.J.1    Kim, B.S.2
  • 29
    • 33845936631 scopus 로고    scopus 로고
    • Serum-free suspension large-scale transient transfection of CHO cells in WAVE bioreactors
    • DOI 10.1385/MB:34:2:191, PII MB342191
    • Haldankar R, Li DQ, Saremi Z, Baikalov C, Deshpande R (2006) Serum-free suspension large-scale transient transfection of CHO cells in WAVE bioreactors. Mol Biotechnol 34:191-199 (Pubitemid 46030392)
    • (2006) Molecular Biotechnology , vol.34 , Issue.2 , pp. 191-199
    • Haldankar, R.1    Li, D.2    Saremi, Z.3    Baikalov, C.4    Deshpande, R.5
  • 30
    • 0011444544 scopus 로고    scopus 로고
    • Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina
    • Horbinski C, Stachowiak MK, Higgins D, Finnegan SG (2001) Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina. BMC Neurosci 2:2
    • (2001) BMC Neurosci , vol.2 , pp. 2
    • Horbinski, C.1    Stachowiak, M.K.2    Higgins, D.3    Finnegan, S.G.4
  • 31
    • 33748072123 scopus 로고    scopus 로고
    • Combination of 3D tissue engineered scaffold and non-viral gene carrier enhance in vitro DNA expression of mesenchymal stem cells
    • DOI 10.1016/j.biomaterials.2006.02.033, PII S0142961206001876
    • Hosseinkhani H, Azzam T, Kobayashi H, Hiraoka Y, Shimokawa H, Domb AJ, Tabata Y (2006) Combination of 3D tissue engineered scaffold and non-viral gene carrier enhance in vitro DNA expression of mesenchymal stem cells. Biomaterials 27:4269-4278 (Pubitemid 44294360)
    • (2006) Biomaterials , vol.27 , Issue.23 , pp. 4269-4278
    • Hosseinkhani, H.1    Azzam, T.2    Kobayashi, H.3    Hiraoka, Y.4    Shimokawa, H.5    Domb, A.J.6    Tabata, Y.7
  • 32
    • 15444381040 scopus 로고    scopus 로고
    • Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4)
    • DOI 10.1038/sj.gt.3302439
    • Huang YC, Simmons C, Kaigler D, Rice KG, Mooney DJ (2005) Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther 12:418-426 (Pubitemid 40394294)
    • (2005) Gene Therapy , vol.12 , Issue.5 , pp. 418-426
    • Huang, Y.-C.1    Simmons, C.2    Kaigler, D.3    Rice, K.G.4    Mooney, D.J.5
  • 33
    • 33646105844 scopus 로고    scopus 로고
    • An immortalized drug-resistant cell line established from 12-13-day mouse embryos for the propagation of human embryonic stem cells
    • Iuchi S, Marsch-Moreno M, Velez-DelValle C, Easley K, Kuri- Harcuch W, Green H (2006) An immortalized drug-resistant cell line established from 12-13-day mouse embryos for the propagation of human embryonic stem cells. Differentiation 74:160-166
    • (2006) Differentiation , vol.74 , pp. 160-166
    • Iuchi, S.1    Marsch-Moreno, M.2    Velez-DelValle, C.3    Easley, K.4    Kuri-Harcuch, W.5    Green, H.6
  • 34
    • 33847073124 scopus 로고    scopus 로고
    • Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: Benefit of a novel nonviral vector, cationized dextran
    • Jo J, Nagaya N, Miyahara Y, Kataoka M, Harada-Shiba M, Kangawa K, Tabata Y (2007) Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: benefit of a novel nonviral vector, cationized dextran. Tissue Eng 13:313-322
    • (2007) Tissue Eng , vol.13 , pp. 313-322
    • Jo, J.1    Nagaya, N.2    Miyahara, Y.3    Kataoka, M.4    Harada-Shiba, M.5    Kangawa, K.6    Tabata, Y.7
  • 35
    • 32044467131 scopus 로고    scopus 로고
    • Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells
    • DOI 10.1089/scd.2005.14.621
    • Koch H, Jadlowiec JA, Campbell PG (2005) Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells. Stem Cells Dev 14:621-631 (Pubitemid 43201896)
    • (2005) Stem Cells and Development , vol.14 , Issue.6 , pp. 621-631
    • Koch, H.1    Jadlowiec, J.A.2    Campbell, P.G.3
  • 36
    • 0037437033 scopus 로고    scopus 로고
    • Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: Comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine
    • DOI 10.1016/S0168-3659(03)00076-2
    • Kunath K, von Harpe A, Fischer D, Peterson H, Bickel U, Voigt K, Kissel T (2003) Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular- weight polyethylenimine. J Control Release 89:113-125 (Pubitemid 36412116)
    • (2003) Journal of Controlled Release , vol.89 , Issue.1 , pp. 113-125
    • Kunath, K.1    Von Harpe, A.2    Fischer, D.3    Petersen, H.4    Bickel, U.5    Voigt, K.6    Kissel, T.7
  • 40
    • 0036376763 scopus 로고    scopus 로고
    • Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage
    • DOI 10.1089/10430340260201716
    • Madry H, Padera R, Seidel J, Langer R, Freed LE, Trippel SB, Vunjak- Novakovic G (2002) Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum Gene Ther 13:1621-1630 (Pubitemid 35034682)
    • (2002) Human Gene Therapy , vol.13 , Issue.13 , pp. 1621-1630
    • Madry, H.1    Padera, R.2    Seidel, J.3    Langer, R.4    Freed, L.E.5    Trippel, S.B.6    Vunjak-Novakovic, G.7
  • 41
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • DOI 10.1016/S1534-5807(04)00075-9, PII S1534580704000759
    • McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6:483-495 (Pubitemid 38456178)
    • (2004) Developmental Cell , vol.6 , Issue.4 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 42
    • 54049112682 scopus 로고    scopus 로고
    • Optimizing transient gene expression
    • Morrow KJ (2008) Optimizing transient gene expression. Genet Eng News 28:54-59
    • (2008) Genet Eng News , vol.28 , pp. 54-59
    • Morrow, K.J.1
  • 43
    • 24644504130 scopus 로고    scopus 로고
    • Toxicogenomics of cationic lipid-based vectors for gene therapy: Impact of microarray technology
    • DOI 10.2174/156720105774370249
    • Omidi Y, Barar J, Akhtar S (2005) Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology. Curr Drug Deliv 2:429-441 (Pubitemid 41277775)
    • (2005) Current Drug Delivery , vol.2 , Issue.4 , pp. 429-441
    • Omidi, Y.1    Barar, J.2    Akhtar, S.3
  • 44
    • 0347756922 scopus 로고    scopus 로고
    • Toxicogenomics of non-viral vectors for gene therapy: A microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells
    • DOI 10.1080/10611860310001636908
    • Omidi Y, Hollins AJ, Benboubetra M, Drayton R, Benter IF, Akhtar S (2003) Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells. J Drug Target 11:311-323 (Pubitemid 38081335)
    • (2003) Journal of Drug Targeting , vol.11 , Issue.6 , pp. 311-323
    • Omidi, Y.1    Hollins, A.J.2    Benboubetra, M.3    Drayton, R.4    Benter, I.F.5    Akhtari, S.6
  • 45
  • 46
    • 34347345147 scopus 로고    scopus 로고
    • Tissue-engineered bone formation with gene transfer and mesenchymal stem cells in a minimally invasive technique
    • DOI 10.1097/MLG.0b013e31805f680e
    • Park DJ, Choi JH, Leong KW, Kwon JW, Eun HS (2007) Tissue-engineered bone formation with gene transfer and mesenchymal stem cells in a minimally invasive technique. Laryngoscope 117:1267-1271 (Pubitemid 47015680)
    • (2007) Laryngoscope , vol.117 , Issue.7 , pp. 1267-1271
    • Park, D.-J.1    Choi, J.H.2    Leong, K.W.3    Kwon, J.-W.4    Eun, H.S.5
  • 49
    • 60649096454 scopus 로고    scopus 로고
    • Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as gene delivery vectors
    • Santos JL, Oramas E, Pego AP, Granja PL, Tomas H (2009) Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as gene delivery vectors. J Control Release 134:141-148
    • (2009) J Control Release , vol.134 , pp. 141-148
    • Santos, J.L.1    Oramas, E.2    Pego, A.P.3    Granja, P.L.4    Tomas, H.5
  • 50
    • 41949107664 scopus 로고    scopus 로고
    • Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells
    • DOI 10.1021/bm701146f
    • Saraf A, Hacker MC, Sitharaman B, Grande-Allen KJ, Barry MA, Mikos AG (2008) Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules 9:818-827 (Pubitemid 351560471)
    • (2008) Biomacromolecules , vol.9 , Issue.3 , pp. 818-827
    • Saraf, A.1    Hacker, M.C.2    Sitharaman, B.3    Grande-Allen, K.J.4    Barry, M.A.5    Mikos, A.G.6
  • 51
    • 0033017213 scopus 로고    scopus 로고
    • DNA delivery from polymer matrices for tissue engineering
    • DOI 10.1038/9853
    • Shea LD, Smiley E, Bonadio J, Mooney DJ (1999) DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol 17:551-554 (Pubitemid 29262917)
    • (1999) Nature Biotechnology , vol.17 , Issue.6 , pp. 551-554
    • Shea, L.D.1    Smiley, E.2    Bonadio, J.3    Mooney, D.J.4
  • 54
    • 37148999397 scopus 로고    scopus 로고
    • Novel orbital shake bioreactors for transient production of CHO derived IgGs
    • DOI 10.1021/bp070219i
    • Stettler M, Zhang XW, Hacker DL, De Jesus M, Wurm FM (2007) Novel orbital shake bioreactors for transient production of CHO derived IgGs. Biotechnol Prog 23:1340-1346 (Pubitemid 350261869)
    • (2007) Biotechnology Progress , vol.23 , Issue.6 , pp. 1340-1346
    • Stettler, M.1    Zhang, X.2    Hacker, D.L.3    De Jesus, M.4    Wurm, F.M.5
  • 55
    • 57749186665 scopus 로고    scopus 로고
    • Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds
    • Sun XD, Jeng L, Bolliet C, Olsen BR, Spector M (2009) Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds. Biomaterials 30:1222-1231
    • (2009) Biomaterials , vol.30 , pp. 1222-1231
    • Sun, X.D.1    Jeng, L.2    Bolliet, C.3    Olsen, B.R.4    Spector, M.5
  • 56
    • 35448976077 scopus 로고    scopus 로고
    • Manufacture of a human mesenchymal stem cell population using an automated cell culture platform
    • DOI 10.1007/s10616-007-9091-2
    • Thomas RJ, Chandra A, Liu Y, Hourd PC, Conway PP, Williams DJ (2007) Manufacture of a human mesenchymal stem cell population using an automated cell culture platform. Cytotechnology 55:31-39 (Pubitemid 47622172)
    • (2007) Cytotechnology , vol.55 , Issue.1 , pp. 31-39
    • Thomas, R.J.1    Chandra, A.2    Liu, Y.3    Hourd, P.C.4    Conway, P.P.5    Williams, D.J.6
  • 57
    • 49949108324 scopus 로고    scopus 로고
    • Application of process quality engineering techniques to improve the understanding of the in vitro processing of stem cells for therapeutic use
    • Thomas RJ, Hourd PC, Williams DJ (2008) Application of process quality engineering techniques to improve the understanding of the in vitro processing of stem cells for therapeutic use. J Biotechnol 136:148-155
    • (2008) J Biotechnol , vol.136 , pp. 148-155
    • Thomas, R.J.1    Hourd, P.C.2    Williams, D.J.3
  • 60
    • 0037423736 scopus 로고    scopus 로고
    • Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells
    • DOI 10.1016/S0006-291X(02)03026-7
    • Tsuchiya H, Kitoh H, Sugiura F, Ishiguro N (2003) Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 301:338-343 (Pubitemid 36279243)
    • (2003) Biochemical and Biophysical Research Communications , vol.301 , Issue.2 , pp. 338-343
    • Tsuchiya, H.1    Kitoh, H.2    Sugiura, F.3    Ishiguro, N.4
  • 61
    • 40149107402 scopus 로고    scopus 로고
    • Development of a generic transient transfection process at 100 L scale
    • Tuvesson O, Uhe C, Rozkov A, Lullau E (2008) Development of a generic transient transfection process at 100 L scale. Cytotechnology 56:123-136
    • (2008) Cytotechnology , vol.56 , pp. 123-136
    • Tuvesson, O.1    Uhe, C.2    Rozkov, A.3    Lullau, E.4
  • 62
    • 67650547297 scopus 로고    scopus 로고
    • MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells
    • Wang Y, Wang M, Abarbanell AM, Weil BR, Herrmann JL, Tan J, Novotny NM, Coffey AC, Meldrum DR (2009) MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells. Surgery 146:198-205
    • (2009) Surgery , vol.146 , pp. 198-205
    • Wang, Y.1    Wang, M.2    Abarbanell, A.M.3    Weil, B.R.4    Herrmann, J.L.5    Tan, J.6    Novotny, N.M.7    Coffey, A.C.8    Meldrum, D.R.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.